Pre-synaptic glutamate-induced activation of DA release in the striatum after partial nigral lesion. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Neurochemistry Année : 2010

Pre-synaptic glutamate-induced activation of DA release in the striatum after partial nigral lesion.

Résumé

The present experiments aimed at understanding the functional link between dopamine (DA) and glutamate (GLU) during the compensatory processes taking place after partial DA denervation. Lesion of the lateral part of substantia nigra in rats using 6-hydroxydopamine resulted in DA denervation of the lateral region of the ipsilateral caudate/putamen complex (CPc) whereas the medial CPc was spared. In vivo voltammetry revealed a large increase of extracellular dopamine (DA(ext)) in the medial CPc both ipsilateral and contralateral to the lesion. In addition, in vivo microdialysis and HPLC-ED revealed a concomitant increase of extracellular glutamate (GLU(ext)) in the ipsilateral medial CPc. Post-lesion chronic treatment with the putative neuroprotectors amantadine, memantine, and riluzole counteracted the tonic increases of DA(ext) and GLU(ext), revealing a possible role of GLU neurotransmission in the DA over-expression. Finally, acute low doses of GBR12909 had no effect on the DA(ext) in sham- operated animals, but dramatically increased DA(ext) in lesioned animals. The data suggest that a partial unilateral nigral lesion induces a bilateral increase of DA turn-over in the non-denervated striata through GLU afferences to the DA terminals.
Fichier sous embargo
Fichier sous embargo
Date de visibilité indéterminée
Loading...

Dates et versions

inserm-00627888 , version 1 (01-02-2012)

Identifiants

Citer

Kwamivi Dzahini, Christine Dentresangle, Marion Le Cavorsin, Anne Bertrand, Isabelle Detraz, et al.. Pre-synaptic glutamate-induced activation of DA release in the striatum after partial nigral lesion.. Journal of Neurochemistry, 2010, 113 (6), pp.1459-70. ⟨10.1111/j.1471-4159.2010.06682.x⟩. ⟨inserm-00627888⟩
93 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More