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Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.

Abstract : PURPOSE: Mantle cell lymphoma (MCL) is a chemoresistant lymphoma overexpressing the class pi glutathione-S-transferase (GST-pi). The nuclear localisation of GST-pi is induced by chemotherapy and is correlated to cell resistance. In this study, the effect of the Agaricus bisporus lectin (ABL), a GST-pi nuclear transfer inhibitor, on the chemosensitivity of MCL cells was investigated. METHODS: The proliferation of three MCL cell lines was evaluated in the presence of doxorubicin (DOX), cisplatin (CDDP), cytarabine (Ara-C), gemcitabine (GEM) or bortezomib with or without ABL pre-treatment. RESULTS: The cytotoxic activities of CDDP, Ara-C, GEM and bortezomib were increased in all cell lines. The DOX cytotoxic activity was enhanced in two of three cell lines. The inhibition of GST-pi nuclear transfer led to the potentialisation of all drug combinations. CONCLUSION: The inhibition of the nuclear transfer of GST-pi increases the MCL sensitivity to DOX, CDDP, Ara-C, GEM and bortezomib, alone or in combination.
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https://www.hal.inserm.fr/inserm-00625608
Contributor : Jean-Paul Issartel <>
Submitted on : Thursday, September 22, 2011 - 9:49:53 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:39 AM

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  • HAL Id : inserm-00625608, version 1
  • PUBMED : 21036708

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Delphine Rolland, Mahatsangy Raharijaona, Aurélie Barbarat, Rémi Houlgatte, Catherine Thieblemont. Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.. Anticancer Research, International Institute of Anticancer Research, 2010, 30 (10), pp.3951-7. ⟨inserm-00625608⟩

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