C. Baigent, A. Keech, P. Kearney, L. Blackwell, G. Buck et al., Cholesterol Treatment Trialists' (CTT) Collaborators: Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins, Lancet, vol.366, pp.1267-1278, 2005.

A. Mekontso-dessap and C. Brun-buisson, Statins: the next step in adjuvant therapy for sepsis? Intensive Care Med, pp.11-14, 2006.

J. Jacobson, Statins in Endothelial Signaling and Activation, Antioxidants & Redox Signaling, vol.11, issue.4, pp.811-821, 2009.
DOI : 10.1089/ars.2008.2284

S. Janda, A. Young, J. Fitzgerald, M. Etminan, and J. Swiston, The effect of statins on mortality from severe infections and sepsis: A systematic review and meta-analysis, Journal of Critical Care, vol.25, issue.4, pp.656-657, 2010.
DOI : 10.1016/j.jcrc.2010.02.013

M. Levy, M. Fink, J. Marshall, E. Abraham, D. Angus et al., 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, pp.1250-1256, 2001.
DOI : 10.1097/01.CCM.0000050454.01978.3B

R. Dellinger, J. Carlet, H. Masur, H. Gerlach, C. T. Cohen et al., Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock, Critical Care Medicine, vol.32, issue.3, pp.536-555, 2004.
DOI : 10.1097/01.CCM.0000117317.18092.E4

G. Bahrami, B. Mohammadi, S. Mirzaeei, and A. Kiani, Determination of atorvastatin in human serum by reversed-phase high-performance liquid chromatography with UV detection, Journal of Chromatography B, vol.826, issue.1-2, pp.41-45, 2005.
DOI : 10.1016/j.jchromb.2005.08.008

J. Vincent, A. De-mendonca, F. Cantraine, R. Moreno, J. Takala et al., Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units, Critical Care Medicine, vol.26, issue.11, pp.1793-1800, 1998.
DOI : 10.1097/00003246-199811000-00016

J. Vincent, R. Moreno, J. Takala, S. Willatts, D. Mendonca et al., The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure, Intensive Care Medicine, vol.21, issue.7, pp.707-710, 1996.
DOI : 10.1007/BF01709751

P. Austin, Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples, Statistics in Medicine, vol.17, issue.1, pp.3083-3107, 2009.
DOI : 10.1002/sim.3697

P. Austin and M. Mamdani, A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use, Statistics in Medicine, vol.288, issue.12, pp.2084-2106, 2006.
DOI : 10.1002/sim.2328

E. Gayat, R. Pirracchio, M. Resche-rigon, A. Mebazaa, J. Mary et al., Propensity scores in intensive care and anaesthesiology literature: a systematic review, Intensive Care Medicine, vol.24, issue.12, pp.1993-2003, 2010.
DOI : 10.1007/s00134-010-1991-5

D. Wijeysundera, W. Beattie, P. Austin, J. Hux, and A. Laupacis, Epidural anaesthesia and survival after intermediate-to-high risk non-cardiac surgery: a population-based cohort study, The Lancet, vol.372, issue.9638, pp.562-569, 2008.
DOI : 10.1016/S0140-6736(08)61121-6

S. Senn, E. Graf, and A. Caputo, Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure, Statistics in Medicine, vol.4, issue.30, pp.5529-5544, 2007.
DOI : 10.1002/sim.3133

P. Kopterides and M. Falagas, Statins for sepsis: a critical and updated review, Clinical Microbiology and Infection, vol.15, issue.4, pp.325-334, 2009.
DOI : 10.1111/j.1469-0691.2009.02750.x

M. Falagas, G. Makris, D. Matthaiou, and P. Rafailidis, Statins for infection and sepsis: a systematic review of the clinical evidence, Journal of Antimicrobial Chemotherapy, vol.61, issue.4, pp.774-785, 2008.
DOI : 10.1093/jac/dkn019

I. Tleyjeh, T. Kashour, F. Hakim, V. Zimmerman, P. Erwin et al., Statins for the Prevention and Treatment of Infections, Archives of Internal Medicine, vol.169, issue.18, pp.1658-1667, 2009.
DOI : 10.1001/archinternmed.2009.286

P. Kruger, K. Fitzsimmons, D. Cook, M. Jones, and G. Nimmo, Statin therapy is associated with fewer deaths in patients with bacteraemia, Intensive Care Medicine, vol.340, issue.1, pp.75-79, 2006.
DOI : 10.1007/s00134-005-2859-y

P. Van-der-harst, F. Asselbergs, H. Hillege, S. Bakker, A. Voors et al., Effect of Withdrawal of Pravastatin Therapy on C-Reactive Protein and Low-Density Lipoprotein Cholesterol, The American Journal of Cardiology, vol.100, issue.10, pp.1548-1551, 2007.
DOI : 10.1016/j.amjcard.2007.06.054

L. Cubeddu and M. Seamon, Statin Withdrawal: Clinical Implications and Molecular Mechanisms, Pharmacotherapy, vol.59, issue.3, pp.1288-1296, 2006.
DOI : 10.1161/01.STR.0000143319.73503.38

J. Li, Y. Li, J. Chen, and J. Yang, Rebound phenomenon of inflammatory response may be a major mechanism responsible for increased cardiovascular events after abrupt cessation of statin therapy, Medical Hypotheses, vol.66, issue.6, pp.1199-1204, 2006.
DOI : 10.1016/j.mehy.2005.06.035

P. Kruger, M. Harward, M. Jones, C. Joyce, K. Kostner et al., Continuation of statin therapy in patients with presumed Figure 4 Atorvastatin plasma concentrations before and 90 minutes after receiving a 40 mg dose in nine critically ill septic patients continuing this drug while under cytochrome P450 3A4 inhibitors (in red) or not (in black) Two patients were assessed twice (circles). The residual concentrations

M. Dessap, Critical CareR171 infection: a randomised controlled trial, Am J Respir Crit Care Med, vol.1515, issue.201, pp.171-774, 2011.

P. Kruger, N. Freir, B. Venkatesh, T. Robertson, M. Roberts et al., A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis, Intensive Care Medicine, vol.8, issue.4, pp.717-721, 2009.
DOI : 10.1007/s00134-008-1358-3

R. Knopp, Drug treatment of lipid disorders, N Engl J Med, vol.341, pp.498-511, 1999.

S. Bellosta, R. Paoletti, and A. Corsini, Safety of Statins: Focus on Clinical Pharmacokinetics and Drug Interactions, Circulation, vol.109, issue.23_suppl_1, pp.50-57, 2004.
DOI : 10.1161/01.CIR.0000131519.15067.1f

A. Vincent and J. Miller, Statins for sepsis: a cautionary note, Intensive Care Medicine, vol.106, issue.5, p.795, 2006.
DOI : 10.1007/s00134-006-0143-4

M. Mohaupt, R. Karas, E. Babiychuk, V. Sanchez-freire, K. Monastyrskaya et al., Association between statin-associated myopathy and skeletal muscle damage, Canadian Medical Association Journal, vol.181, issue.1-2, pp.11-18, 2009.
DOI : 10.1503/cmaj.081785

R. Thomsen, H. Hundborg, S. Johnsen, L. Pedersen, H. Sorensen et al., Statin use and mortality within 180 days after bacteremia: A population-based cohort study*, Critical Care Medicine, vol.34, issue.4, pp.1080-1086, 2006.
DOI : 10.1097/01.CCM.0000207345.92928.E4

W. Mccabe and G. J. , Gram-Negative Bacteremia, Archives of Internal Medicine, vol.110, issue.6, pp.847-855, 1963.
DOI : 10.1001/archinte.1962.03620240029006