, Laura Boyes); South West Regional Genetics Service, East Anglian Regional Genetics Service Medical Genetics Services for Wales
, South East of Scotland Regional Genetics Service, Edinburgh (Mary Porteous); Peninsula Clinical Genetics Service, North West Thames Regional Genetics Service, Kennedy-Galton Centre
, Catherine Houghton); Manchester Regional Genetics Service, Cheryl Berlin) Nottingham Centre for Medical Genetics
, North Trent Clinical Genetics Cathryn Bardsley); South Essex Cancer Research NetworkAnne Robinson); South West Thames Regional Genetics Service); and Wessex Clinical Genetics Service
, France) is supported by the Ligue National Contre le Cancer, the Association for International Cancer Research Grant (AICR-07-0454), and the Association Le cancer du sein, parlons-en! Award. The authors wish to thank all of the GEMO collaborating groups for their contribution to this study. GEMO collaborating centers include: Coordinating Centres
, Villejuif (Brigitte Bressac-de-Paillerets
, Chrystelle Colas, Florent Soubrier); CHU de Arnaud-de-Villeneuve, Pascal Pujol
, Viviane Feillel), Christine Rebischung Laurence Faivre
, Nice (Marc Frénay); CHU de Limoges (Laurence Vénat-Bouvet); CHU de Nantes (Capucine Delnatte); and
, http://breast-cancer-research.com/content, Breast Cancer Research, vol.12126, p.102, 2010.
, This research project has been supported by the Austrian Society for Endocrinological Oncology and by the Comprehensive Cancer Center, Cluster Genetics and Epigenetics. Georgetown acknowledges Claudine Isaacs and is supported by a National Cancer Institute Cancer Centre Support Grant to the Lombardi Comprehensive Cancer Centre (NCI P30, pp.51008-51020
, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 15 Cotswold Road
, 35 Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Western Bank, Curie Boulevard, 1090.
, 38 Women's Cancer Program, Fox Chase Cancer Center, p.333
, Haartmaninkatu 8, 00290 Helsinki, Finland. 40 Department of Pathology, University Hospital and University of Iceland School of Medicine, 101 Reykjavik, Iceland. 41 Section of Genetic Oncology, p.64, 19111.
, S-41345 Gothenburg, Sweden. 46 Department of Radiation Sciences, Oncology, p.47
, http://breast-cancer-research.com/content/12/6/R102 mutations detected in case Series unselected for family history: a combined analysis of 22 studies, Breast Cancer Research Am J Hum Genet, vol.12, issue.72, pp.1021117-1130, 2003.
, Mutations in a Large United States Sample, Journal of Clinical Oncology, vol.24, issue.6, pp.863-871, 2006.
DOI : 10.1200/JCO.2005.03.6772
, Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium, Am J Hum Genet, vol.56, pp.265-271, 1995.
, Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence, Am J Hum Genet, vol.57, pp.1457-1462, 1995.
, The Average Cumulative Risks of Breast and Ovarian Cancer for Carriers of Mutations in BRCA1 and BRCA2 Attending Genetic Counseling Units in Spain, Clinical Cancer Research, vol.14, issue.9, pp.2861-2869, 2008.
DOI : 10.1158/1078-0432.CCR-07-4436
, Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population, Proceedings of the National Academy of Sciences, vol.103, issue.10, pp.3770-3774, 2006.
DOI : 10.1073/pnas.0511301103
, RAD51 135G???C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies, The American Journal of Human Genetics, vol.81, issue.6, pp.511186-1200, 2007.
DOI : 10.1086/522611
, Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers, The American Journal of Human Genetics, vol.82, issue.4, pp.937-948, 2008.
DOI : 10.1016/j.ajhg.2008.02.008
, AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A Consortium of Investigators of Modifiers of BRCA1/2 Study, Cancer Epidemiology Biomarkers & Prevention, vol.16, issue.7, pp.1416-1421, 2007.
DOI : 10.1158/1055-9965.EPI-07-0129
, No evidence that GATA3 rs570613 SNP modifies breast cancer risk, Breast Cancer Research and Treatment, vol.20, issue.2, pp.371-379, 2009.
DOI : 10.1007/s10549-008-0257-1
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728174
, No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study, Breast Cancer Research and Treatment, vol.39, issue.5, pp.185-192, 2009.
DOI : 10.1007/s10549-008-0064-8
, Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers, Human Molecular Genetics, vol.18, issue.22, pp.4442-4456, 2009.
DOI : 10.1093/hmg/ddp372
, The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers, Breast Cancer Research and Treatment, vol.27, issue.7, pp.639-649, 2010.
DOI : 10.1007/s10549-009-0595-7
, Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA), British Journal of Cancer, vol.4, issue.12, pp.2048-2054, 2009.
DOI : 10.1093/carcin/bgn193
, The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers, British Journal of Cancer, vol.61, issue.8, pp.1456-1460, 2009.
DOI : 10.1007/s10549-007-9797-z
, Genome-wide association study identifies novel breast cancer susceptibility loci, Nature, vol.70, issue.7148, pp.1087-1093, 2007.
DOI : 10.1038/nature05887
, An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA), Breast Cancer Research, vol.11, issue.2, p.104, 2007.
DOI : 10.1158/1078-0432.CCR-04-2424
, Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers, Breast Cancer Research and Treatment, vol.9, issue.10, pp.229-236, 2008.
DOI : 10.1007/s10549-007-9848-5
, A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer, Nature Genetics, vol.164, issue.7, pp.870-874, 2007.
DOI : 10.1371/journal.pgen.0020190
, Association Between a Germline OCA2 Polymorphism at Chromosome 15q13.1 and Estrogen Receptor-Negative Breast Cancer Survival, JNCI Journal of the National Cancer Institute, vol.102, issue.9, pp.650-662, 2010.
DOI : 10.1093/jnci/djq057
, A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes, Genetic Epidemiology, vol.10, issue.1, pp.1-11, 2005.
DOI : 10.1002/gepi.20074
, Mutation Carriers, Journal of Clinical Oncology, vol.23, issue.34, pp.8629-8635, 2005.
DOI : 10.1200/JCO.2005.02.9199
, Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers, European Journal of Cancer, vol.38, pp.1616-1622, 2002.
DOI : 10.1016/S0959-8049(02)00269-1
, http://breast-cancer-research.com/content, Breast Cancer Research, vol.12126, p.102, 2010.
, BRCA2 and Smad3 synergize in regulation of gene transcription, Oncogene, vol.21, issue.36, pp.5660-5664, 2002.
DOI : 10.1038/sj.onc.1205732
, Transforming growth factor-?? in breast cancer: too much, too late, Breast Cancer Research, vol.112, issue.1, p.202, 2009.
DOI : 10.1172/JCI200320530
, Decreased TGF?? signaling and increased COX2 expression in high risk women with increased mammographic breast density, Breast Cancer Research and Treatment, vol.2, issue.9, pp.305-314, 2010.
DOI : 10.1007/s10549-009-0350-0
, A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor???negative breast cancer in the general population, Nature Genetics, vol.447, issue.10, pp.885-892, 2010.
DOI : 10.1002/gepi.1370050611
URL : https://hal.archives-ouvertes.fr/hal-00698376