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What do we learn from a Genome Wide Association Study performed on HIV-1 infected Long Term Non Progressors individuals?

Abstract : Previous Genome Wide Association Studies performed on Elite Controllers and control HIV-1 infected individuals have shown that the MHC locus is predominantly responsible for containing plasma viremia below a threshold of detection. Here we performed a GWAS on a cohort of 160 HIV-1 infected Caucasian Long Term Non Progressors (LTNP) from the EC-funded European-African ''GISHEAL'' Consortium in order to explore whether novel genetic factors could account for the LTNP phenotype (i.e. maintenance of CD4 T cell counts >500 cells/μl and good health conditions without therapy).
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https://www.hal.inserm.fr/inserm-00622545
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Submitted on : Monday, September 12, 2011 - 2:53:42 PM
Last modification on : Tuesday, March 17, 2020 - 2:01:15 AM
Long-term archiving on: : Tuesday, December 13, 2011 - 2:35:25 AM

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Julien Guergnon, Cyril Dalmasso, Ioannis Theodorou, Agostino Riva. What do we learn from a Genome Wide Association Study performed on HIV-1 infected Long Term Non Progressors individuals?. Retrovirology, BioMed Central, 2009, 6 (Suppl 2), pp.O27. ⟨10.1186/1742-4690-6-S2-O27⟩. ⟨inserm-00622545⟩

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