Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes]. - Archive ouverte HAL Access content directly
Journal Articles Gynécologie Obstétrique & Fertilité Year : 2011

Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes].

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Abstract

Klinefelter syndrome is defined by the presence of a supernumerary X chromosome in a phenotypic male. It is the most frequent gonosomic anomaly in infertile men with an incidence of 0.1 to 0.2% in newborn males. The presence of an additional X chromosome induces spermatogenic failure but when gametes are present, they are usually normal. The risk of transmission of the chromosomal anomaly remains low. In the literature, only one 47,XXY foetus resulting from more than a hundred births from fathers with Klinefelter syndrome, has been reported. One can estimate, that a TESE performed in half of the patients with non-mosaic 47,XXY will be positive and may enable IVF/ICSI to be achieved.
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Dates and versions

inserm-00620761 , version 1 (08-09-2011)

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Célia Ravel, Sandra Chantot-Bastaraud, J. Cretet, Patricia Roynard, Mathilde Sibony, et al.. Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes].. Gynécologie Obstétrique & Fertilité, 2011, 39 (9), pp.525-8. ⟨10.1016/j.gyobfe.2011.07.003⟩. ⟨inserm-00620761⟩
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