Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes]. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Gynécologie Obstétrique & Fertilité Année : 2011

Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes].

Résumé

Klinefelter syndrome is defined by the presence of a supernumerary X chromosome in a phenotypic male. It is the most frequent gonosomic anomaly in infertile men with an incidence of 0.1 to 0.2% in newborn males. The presence of an additional X chromosome induces spermatogenic failure but when gametes are present, they are usually normal. The risk of transmission of the chromosomal anomaly remains low. In the literature, only one 47,XXY foetus resulting from more than a hundred births from fathers with Klinefelter syndrome, has been reported. One can estimate, that a TESE performed in half of the patients with non-mosaic 47,XXY will be positive and may enable IVF/ICSI to be achieved.

Dates et versions

inserm-00620761 , version 1 (08-09-2011)

Identifiants

Citer

Célia Ravel, Sandra Chantot-Bastaraud, J. Cretet, Patricia Roynard, Mathilde Sibony, et al.. Syndrome de Klinefelter : qualité des gamètes et spermatogenèse. [Klinefelter syndrome: spermatogenesis and quality of gametes].. Gynécologie Obstétrique & Fertilité, 2011, 39 (9), pp.525-8. ⟨10.1016/j.gyobfe.2011.07.003⟩. ⟨inserm-00620761⟩
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