Three kidneys, two diseases, one antibody?

Nolwenn Lorcy 1 Nathalie Rioux-Leclercq 2 Marie-Laure Lombard 3 Patrick Le Pogamp 1 Cécile Vigneau 1, 4, *
* Auteur correspondant
1 Service de néphrologie
2 Service d'anatomie et cytologie pathologiques [Rennes]
3 Service de néphrologie et d'hémodialyse
4 IGDR - Institut de Génétique et Développement de Rennes
Abstract : Anti-factor H antibody has been recently described as responsible for thrombotic microangiopathies (TMA) as well as membranoproliferative glomerulonephritis (MPGN). We report here, for the first time, the case of a woman with an anti-factor H antibody, who developed MPGN on native kidney, rapid recurrence on first graft, and TMA on second graft despite immunosuppressive therapy and plasma exchanges. This case supports the hypothesis that MPGN and TMA are closely linked by common pathogenic mechanisms and the need for complete exploration of complement pathway including factor H activity and autoantibody in front of any MPGN.
Keywords : anti-factor H antibody complement alternative pathway membranoproliferative glomerulonephritis thombotic microangiopathies
Type de document :
Article dans une revue
Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2011, 26 (11), pp.3811-3. 〈10.1093/ndt/gfr436〉
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https://www.hal.inserm.fr/inserm-00618447
Contributeur : Hervé De Villemeur <>
Soumis le : jeudi 1 septembre 2011 - 18:08:46
Dernière modification le : mercredi 16 mai 2018 - 11:23:34

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IGDR | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

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Nolwenn Lorcy, Nathalie Rioux-Leclercq, Marie-Laure Lombard, Patrick Le Pogamp, Cécile Vigneau. Three kidneys, two diseases, one antibody?. Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2011, 26 (11), pp.3811-3. 〈10.1093/ndt/gfr436〉. 〈inserm-00618447〉

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