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Three kidneys, two diseases, one antibody?

Nolwenn Lorcy 1 Nathalie Rioux-Leclercq 2 Marie-Laure Lombard 3 Patrick Le Pogamp 1 Cécile Vigneau 1, 4, *
* Corresponding author
1 Service de néphrologie
2 Service d'anatomie et cytologie pathologiques [Rennes]
3 Service de néphrologie et d'hémodialyse
4 IGDR - Institut de Génétique et Développement de Rennes
Abstract : Anti-factor H antibody has been recently described as responsible for thrombotic microangiopathies (TMA) as well as membranoproliferative glomerulonephritis (MPGN). We report here, for the first time, the case of a woman with an anti-factor H antibody, who developed MPGN on native kidney, rapid recurrence on first graft, and TMA on second graft despite immunosuppressive therapy and plasma exchanges. This case supports the hypothesis that MPGN and TMA are closely linked by common pathogenic mechanisms and the need for complete exploration of complement pathway including factor H activity and autoantibody in front of any MPGN.
Keywords : anti-factor H antibody complement alternative pathway membranoproliferative glomerulonephritis thombotic microangiopathies
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https://www.hal.inserm.fr/inserm-00618447
Contributor : Hervé de Villemeur <>
Submitted on : Thursday, September 1, 2011 - 6:08:46 PM
Last modification on : Thursday, January 14, 2021 - 11:19:57 AM

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INSERM | CNRS | UNIV-RENNES1 | IGDR | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

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Nolwenn Lorcy, Nathalie Rioux-Leclercq, Marie-Laure Lombard, Patrick Le Pogamp, Cécile Vigneau. Three kidneys, two diseases, one antibody?. Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2011, 26 (11), pp.3811-3. ⟨10.1093/ndt/gfr436⟩. ⟨inserm-00618447⟩

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