Skip to Main content Skip to Navigation
Journal articles

No evidence for XMRV association in pediatric idiopathic diseases in France.

Abstract : Retroviruses have been linked to a variety of diseases such as neoplastic and immunodeficiency disorders and neurologic and respiratory diseases. Recently, a novel infectious human retrovirus, the xenotropic murine leukemia virus-related virus (XMRV), has been identified in cohorts of patients with either a familial type of prostate cancer or chronic fatigue syndrome. The apparent unrelatedness of these diseases raised the question of the potential involvement of XMRV in other diseases.Here, we investigated the presence of XMRV in a selection of pediatric idiopathic infectious diseases with symptoms that are suggestive of a retroviral infection, as well as in children with respiratory diseases and in adult patients with spondyloarthritis (SpA). Using a XMRV env-nested PCR, we screened 72 DNA samples obtained from 62 children hospitalized in the Montpellier university hospital (France) for hematological, neurological or inflammatory pathologies, 80 DNA samples from nasopharyngeal aspirates from children with respiratory diseases and 19 DNA samples from SpA. None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies.
Document type :
Journal articles
Complete list of metadatas

Cited literature [27 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00617228
Contributor : Ed. Bmc <>
Submitted on : Friday, August 26, 2011 - 3:39:26 PM
Last modification on : Friday, May 15, 2020 - 12:22:04 PM
Long-term archiving on: : Tuesday, November 13, 2012 - 9:27:05 AM

Files

1742-4690-7-63.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Eric Jeziorski, Vincent Foulongne, Catherine Ludwig, Djamel Louhaem, Gilles Chiocchia, et al.. No evidence for XMRV association in pediatric idiopathic diseases in France.. Retrovirology, BioMed Central, 2010, 7 (1), pp.63. ⟨10.1186/1742-4690-7-63⟩. ⟨inserm-00617228⟩

Share

Metrics

Record views

756

Files downloads

1127