. Woodrow and . Wilson, Database, p.2010

G. Oberdorster, A. Maynard, K. Donaldson, V. Castranova, J. Fitzpatrick et al., Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy, Part Fibre Toxicol, 2005.

K. Donaldson, D. Brown, A. Clouter, R. Duffin, W. Macnee et al., The Pulmonary Toxicology of Ultrafine Particles, Journal of Aerosol Medicine, vol.15, issue.2, pp.213-220, 2002.
DOI : 10.1089/089426802320282338

G. Oberdorster, J. Ferin, and B. Lehnert, Correlation between particle size, in vivo particle persistence, and lung injury, Environmental Health Perspectives, vol.102, issue.Suppl 5, pp.173-179, 1994.
DOI : 10.1289/ehp.94102s5173

H. Johnston, G. Hutchison, F. Christensen, S. Peters, S. Hankin et al., A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity, Critical Reviews in Toxicology, vol.91, issue.4, pp.328-346, 2010.
DOI : 10.1002/smll.200800922

N. Lewinski, V. Colvin, and R. Drezeck, Cytotoxicity of Nanoparticles, Small, vol.1, issue.8, pp.26-49, 2008.
DOI : 10.1002/smll.200700595

H. Jeng and J. Swanson, Toxicity of Metal Oxide Nanoparticles in Mammalian Cells, Journal of Environmental Science and Health, Part A, vol.165, issue.12, pp.2699-2711, 2006.
DOI : 10.1289/ehp.7021

K. Donaldson, L. Tran, L. Jimenez, R. Duffin, D. Newby et al., Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure, Part Fibre Toxicol, vol.2, issue.10, 2005.

A. Schrand, M. Rahman, S. Hussain, J. Schlager, D. Smith et al., Metal-based nanoparticles and their toxicity assessment, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol.36, issue.(suppl, pp.544-568, 2010.
DOI : 10.1002/wnan.103

V. Colvin, The potential environmental impact of engineered nanomaterials, Nature Biotechnology, vol.21, issue.10, pp.1166-1170, 2003.
DOI : 10.1038/nbt875

P. Møller, N. Jacobsen, J. Folkmann, P. Danielsen, L. Mikkelsen et al., Role of oxidative damage in toxicity of particulates, Free Radical Research, vol.612, issue.5, pp.1-46, 2010.
DOI : 10.1080/15287390701601251

N. Li, C. Sioutas, A. Cho, C. Misra, J. Sempf et al., Ultrafine Particulate Pollutants Induce Oxidative Stress and Mitochondrial Damage, Environmental Health Perspectives, vol.111, issue.4, pp.455-460, 2003.
DOI : 10.1289/ehp.6000

URL : http://doi.org/10.1289/ehp.6000

A. Nemmar, P. Hoet, B. Vanquickenborne, D. Dinsdale, M. Thomeer et al., Passage of Inhaled Particles Into the Blood Circulation in Humans, Circulation, vol.105, issue.4, pp.411-414, 2002.
DOI : 10.1161/hc0402.104118

B. Koeneman, Y. Zhang, P. Westerhoff, Y. Chen, J. Crittenden et al., Toxicity and cellular responses of intestinal cells exposed to titanium dioxide, Cell Biology and Toxicology, vol.67, issue.Pt 2, pp.225-238, 2010.
DOI : 10.1007/s10565-009-9132-z

M. Semmler, J. Seitz, F. Erbe, P. Mayer, J. Heyder et al., Long-Term Clearance Kinetics of Inhaled Ultrafine Insoluble Iridium Particles from the Rat Lung, Including Transient Translocation into Secondary Organs, Inhalation Toxicology, vol.16, issue.6-7, pp.453-459, 2004.
DOI : 10.1080/08958370490439650

J. Hillyer and R. Albrecht, Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles, Journal of Pharmaceutical Sciences, vol.90, issue.12, pp.1927-1963, 2001.
DOI : 10.1002/jps.1143

. Pujalté, Particle and Fibre Toxicology, 2011.

A. Elder and G. Oberdorster, Translocation and effects of ultrafine particles outside of the lung, Clin Occup Environ Med, vol.5, issue.4, pp.785-796, 2006.

J. Wang, G. Zhou, C. Chen, H. Yu, T. Wang et al., Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration, Toxicology Letters, vol.168, issue.2, pp.176-185, 2007.
DOI : 10.1016/j.toxlet.2006.12.001

L. Azou, B. Hengé-napoli, M. Mirto, H. Minaro, L. Barrouillet et al., Effects of cadmium and uranium on some in vitro renal targets, Cell Biology and Toxicology, vol.18, issue.5, pp.329-340, 2002.
DOI : 10.1023/A:1019536115152

P. Goering, M. Waalkes, and C. Klaassen, Toxicology of cadmium In Toxicology of metals: biochemical aspects, pp.189-214

R. Yang, L. Chang, J. Wu, M. Tsai, H. Wang et al., Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment, Environmental Health Perspectives, vol.115, issue.9, pp.1339-1343, 2007.
DOI : 10.1289/ehp.10290

S. Choi, H. Lui, W. Misra, P. Tanaka, E. Zimmer et al., Renal clearence of quantum dots, Nat Biotechnol, issue.10, pp.251165-1170, 2007.

A. Péry, C. Brochot, P. Hoet, A. Nemmar, and F. Bois, -Technetium-labelled carbon nanoparticles inhaled by humans, Inhalation Toxicology, vol.18, issue.3, pp.1099-1107, 2009.
DOI : 10.1088/0143-0815/10/3/001

URL : https://hal.archives-ouvertes.fr/hal-00996012

Z. Chen, H. Meng, G. Xing, C. Chen, Y. Zhao et al., Acute toxicological effects of copper nanoparticles in vivo, Toxicology Letters, vol.163, issue.2, pp.109-129, 2006.
DOI : 10.1016/j.toxlet.2005.10.003

L. Azou, B. Jorly, J. On, D. Sellier, E. Moisan et al., In vitro effects of nanoparticles on renal cells, Particle and Fibre Toxicology, vol.5, issue.1, p.22, 2008.
DOI : 10.1186/1743-8977-5-22

I. Dubus, L. Azou, B. Gordien, M. Delmas, Y. Labouyrie et al., Cytoskeletal Reorganization by Mycophenolic Acid Alters Mesangial Cell Migration and Contractility, Hypertension, vol.42, issue.5, pp.956-961, 2003.
DOI : 10.1161/01.HYP.0000097806.45034.45

I. Dubus, S. Sena, J. Labouyrie, J. Bonnet, and C. Combe, In vitro prevention of cyclosporin-induced cell contraction by mycophenolic acid, Life Sciences, vol.77, issue.26, pp.3366-3374, 2005.
DOI : 10.1016/j.lfs.2005.05.050

L. Azou, B. Dubus, I. Ohayon-courtès, C. Cambar, and J. , Human glomerular mesangial IP15 cell line as a suitable model for in vitro cadmium cytotoxicity studies, Cell Biol Toxicol, vol.23, issue.4, pp.267-278, 2007.

P. Gunness, K. Aleksa, K. Kosuge, S. Ito, and G. Koren, Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity, Canadian Journal of Physiology and Pharmacology, vol.88, issue.4, pp.448-555, 2010.
DOI : 10.1139/Y10-023

M. Ryan, G. Johnson, J. Kirk, S. Fuerstenbert, R. Zager et al., HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney, Kidney International, vol.45, issue.1, pp.48-57, 1994.
DOI : 10.1038/ki.1994.6

L. Racusen, C. Monteil, A. Sgrignoli, M. Lucskay, S. Marouillat et al., Cell lines with extended in vitro growth potential from human renal proximal tubule: Characterization, response to inducers, and comparison with established cell lines, Journal of Laboratory and Clinical Medicine, vol.129, issue.3, pp.318-329, 1997.
DOI : 10.1016/S0022-2143(97)90180-3

B. Rzigalinski and J. Strobl, Cadmium-containing nanoparticles: Perspectives on pharmacology and toxicology of quantum dots???, Toxicology and Applied Pharmacology, vol.238, issue.3, pp.280-288, 2009.
DOI : 10.1016/j.taap.2009.04.010

P. Juzenas, W. Chen, Y. Sun, M. Coelho, R. Genralov et al., Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer, Advanced Drug Delivery Reviews, vol.60, issue.15, pp.1600-1614, 2008.
DOI : 10.1016/j.addr.2008.08.004

R. Bakalova, H. Ohba, Z. Zhelev, T. Nagase, R. Jose et al., Role of Free Cadmium and Selenium Ions in the Potential Mechanism for the Enhancement of Photoluminescence of CdSe Quantum Dots Under Ultraviolet Irradiation, Journal of Nanoscience and Nanotechnology, vol.5, issue.6, pp.887-894, 2005.
DOI : 10.1166/jnn.2005.117

G. Oberdorster, E. Oberdorster, and J. Oberdorster, Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles, Environmental Health Perspectives, vol.113, issue.7, pp.823-839, 2005.
DOI : 10.1289/ehp.7339

D. Jong, W. Hagens, W. Krystek, P. Burger, M. Sips et al., Particle size-dependent organ distribution of gold nanoparticles after intravenous administration, Biomaterials, vol.29, issue.12, pp.1912-1921, 2008.
DOI : 10.1016/j.biomaterials.2007.12.037

T. Jain, M. Reddy, M. Morales, D. Leslie-pelecky, and V. Labhasetwar, Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats, Molecular Pharmaceutics, vol.5, issue.2, pp.316-343, 2008.
DOI : 10.1021/mp7001285

A. Burns, J. Vider, H. Ow, E. Herz, O. Penate-medina et al., Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine, Nano Letters, vol.9, issue.1, pp.442-448, 2009.
DOI : 10.1021/nl803405h

M. Schipper, G. Iyer, A. Koh, Z. Cheng, Y. Ebenstein et al., Particle Size, Surface Coating, and PEGylation Influence the Biodistribution of Quantum Dots in Living Mice, Small, vol.51, issue.1, pp.126-134, 2009.
DOI : 10.1002/smll.200800003

K. Berube, D. Balharry, K. Sexton, L. Koshy, and T. Jones, COMBUSTION-DERIVED NANOPARTICLES: MECHANISMS OF PULMONARY TOXICITY, Clinical and Experimental Pharmacology and Physiology, vol.40, issue.10, pp.1044-50, 2007.
DOI : 10.1161/hc0402.104118

W. Kim, J. Kim, J. Park, H. Ryu, and I. Yu, Histological Study of Gender Differences in Accumulation of Silver Nanoparticles in Kidneys of Fischer 344 Rats, Journal of Toxicology and Environmental Health, Part A, vol.287, issue.21-22, pp.72-93, 2009.
DOI : 10.1016/S0014-5793(99)01491-X

M. Valko, H. Morris, and M. Cronin, Metals, Toxicity and Oxidative Stress, Current Medicinal Chemistry, vol.12, issue.10, pp.1161-208, 2005.
DOI : 10.2174/0929867053764635

M. Auffan, J. Rose, M. Wiesnera, and J. Bottero, Chemical stability of metallic nanoparticles: A parameter controlling their potential cellular toxicity in vitro, Environmental Pollution, vol.157, issue.4, pp.1127-1133, 2009.
DOI : 10.1016/j.envpol.2008.10.002

K. Powers, S. Brown, V. Krishna, S. Wasdo, B. Moudgil et al., Research Strategies for Safety Evaluation of Nanomaterials. Part VI. Characterization of Nanoscale Particles for Toxicological Evaluation, Toxicological Sciences, vol.90, issue.2, pp.296-303, 2006.
DOI : 10.1093/toxsci/kfj099

D. Warheit, R. Hoke, C. Finlay, E. Donner, K. Reed et al., Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management, Toxicology Letters, vol.171, issue.3, pp.99-110, 2007.
DOI : 10.1016/j.toxlet.2007.04.008

A. Setyan, J. Sauvain, and M. Rossi, The use of heterogeneous chemistry for the characterization of functional groups at the gas/particle interface of soot and TiO2 nanoparticles, Physical Chemistry Chemical Physics, vol.199, issue.12, pp.6205-6217, 2009.
DOI : 10.1039/b902509j

S. Hussain, L. Thomassen, I. Ferecatu, M. Botot, K. Andreu et al., Carbon black and titanium dioxide nanoparticles elicit distinct apoptosis pathways in bronchial epithelial cells, Part Fibre Toxicol, vol.7, issue.10, 2010.

N. Monteiro-riviere, A. Inman, and L. Zhang, Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line, Toxicology and Applied Pharmacology, vol.234, issue.2, pp.222-235, 2009.
DOI : 10.1016/j.taap.2008.09.030

J. Wörle-knirsch and H. Krug, Oops They Did It Again! Carbon Nanotubes Hoax Scientists in Viability Assays, Nano Letters, vol.6, issue.6, pp.1261-1268, 2006.
DOI : 10.1021/nl060177c

L. Braydich-stolle, N. Schaeublin, R. Murdock, J. Jiang, P. Biswas et al., Crystal structure mediates mode of cell death in TiO2 nanotoxicity, Journal of Nanoparticle Research, vol.5, issue.1, pp.1361-1374, 2009.
DOI : 10.1007/s11051-008-9523-8

A. Smith, H. Duan, A. Mohs, and S. Nie, Bioconjugated quantum dots for in vivo molecular and cellular imaging???, Advanced Drug Delivery Reviews, vol.60, issue.11, pp.601226-1240, 2008.
DOI : 10.1016/j.addr.2008.03.015

T. Xia, M. Kovochich, M. Liong, L. Madler, B. Gilbert et al., Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties, ACS Nano, vol.2, issue.10, pp.2121-2134, 2008.
DOI : 10.1021/nn800511k

C. Jin, B. Zhu, X. Wang, and Q. Lu, Cytotoxicity of Titanium Dioxide Nanoparticles in Mouse Fibroblast Cells, Chemical Research in Toxicology, vol.21, issue.9, pp.1871-1877, 2008.
DOI : 10.1021/tx800179f

D. Miller, Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants?a case of molecular hijacking, Journal of Biochemical and Molecular Toxicology, vol.275, issue.3, pp.121-128, 2002.
DOI : 10.1002/jbt.10030

B. Marquis, S. Love, K. Braun, and C. Haynes, Analytical methods to assess nanoparticle toxicity, The Analyst, vol.2, issue.1, pp.425-439, 2009.
DOI : 10.1039/b818082b

J. Christman, T. Blackwell, and B. Juurlink, Redox Regulation of Nuclear Factor Kappa B: Therapeutic Potential for Attenuating Inflammatory Responses, Brain Pathology, vol.269, issue.Suppl, pp.153-62, 2000.
DOI : 10.1111/j.1750-3639.2000.tb00252.x

F. Mercurio and A. Manning, NF-??B as a primary regulator of the stress response, Oncogene, vol.18, issue.45, pp.6163-71, 1999.
DOI : 10.1038/sj.onc.1203174

V. Stone, J. Shaw, D. Brown, W. Macnee, S. Faux et al., The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function, Toxicology in Vitro, vol.12, issue.6, pp.649-659, 1998.
DOI : 10.1016/S0887-2333(98)00050-2

C. Huang, R. Aronstam, D. Chen, and Y. Huang, Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles, Toxicology in Vitro, vol.24, issue.1, pp.45-55, 2010.
DOI : 10.1016/j.tiv.2009.09.007

H. Hussain, S. Boland, A. Baeza-squiban, R. Hamel, L. Thomassen et al., Oxidative stress and Pujalté et al. Particle and Fibre Toxicology http://www.particleandfibretoxicology.com/content/8/1/10 pro-inflammatory effects of carbon black and titanium dioxide nanoparticles: role of particle surface area and internalized amount, Toxicology, vol.8, issue.260, pp.10142-149, 2009.

E. Park, J. Yi, K. Chung, D. Ryu, J. Choi et al., Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells, Toxicology Letters, vol.180, issue.3, pp.222-231, 2008.
DOI : 10.1016/j.toxlet.2008.06.869

K. Li, J. Chen, S. Bai, X. Wen, S. Song et al., Intracellular oxidative stress and cadmium ions release induce cytotoxicity of unmodified cadmium sulfide quantum dots, Toxicology in Vitro, vol.23, issue.6, pp.1007-1013, 2009.
DOI : 10.1016/j.tiv.2009.06.020

D. Brown, K. Donaldson, P. Borm, R. Schins, M. Dehnhardt et al., Calcium and ROS-mediated activation of transcription factors and TNF-?? cytokine gene expression in macrophages exposed to ultrafine particles, AJP: Lung Cellular and Molecular Physiology, vol.286, issue.2, pp.344-353, 2004.
DOI : 10.1152/ajplung.00139.2003

G. Xiao, M. Wang, and N. Li, Use of Proteomics to Demonstrate a Hierarchical Oxidative Stress Response to Diesel Exhaust Particle Chemicals in a Macrophage Cell Line, Journal of Biological Chemistry, vol.278, issue.50, pp.50781-50790, 2003.
DOI : 10.1074/jbc.M306423200

J. Dong, S. Ramachandiran, K. Tikoo, Z. Jia, S. Lau et al., EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death, AJP: Renal Physiology, vol.287, issue.5, pp.1049-1058, 2004.
DOI : 10.1152/ajprenal.00132.2004

Y. Kim, W. Reed, A. Lenz, I. Jaspers, R. Silbajoris et al., Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells, AJP: Lung Cellular and Molecular Physiology, vol.288, issue.3, pp.432-473, 2005.
DOI : 10.1152/ajplung.00285.2004

C. Ohayon-courtès, I. Passagne, D. Portal, C. Pouvreau, C. Cambar et al., ICP/OES Application for Assessing Cadmium Uptake (or Toxicity) in Glomerular Cells: Influence of Extracellular Calcium, Journal of Toxicology and Environmental Health, Part A, vol.265, issue.9, pp.750-759, 2007.
DOI : 10.1016/S0041-008X(02)00021-2

T. Mosmann, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods, vol.65, issue.1-2, pp.55-63, 1983.
DOI : 10.1016/0022-1759(83)90303-4

J. Crow, Dichlorodihydrofluorescein and Dihydrorhodamine 123 Are Sensitive Indicators of Peroxynitritein Vitro:Implications for Intracellular Measurement of Reactive Nitrogen and Oxygen Species, Nitric Oxide, vol.1, issue.2, pp.145-157, 1997.
DOI : 10.1006/niox.1996.0113

F. Tietze, Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues, Analytical Biochemistry, vol.27, issue.3, pp.502-522, 1969.
DOI : 10.1016/0003-2697(69)90064-5

M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976.
DOI : 10.1016/0003-2697(76)90527-3