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CD39/Adenosine Pathway Is Involved in AIDS Progression.

Abstract : HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhibitory effects are relieved by CD39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine A2A receptor on patients' T cells. Notably, the expansion of the Treg CD39+ correlates with the level of immune activation and lower CD4+ counts in HIV-1 infected patients. Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.
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Contributor : Georges Guellaen Connect in order to contact the contributor
Submitted on : Wednesday, August 24, 2011 - 11:43:30 AM
Last modification on : Wednesday, September 28, 2022 - 5:56:11 AM
Long-term archiving on: : Friday, November 25, 2011 - 12:16:14 PM


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Maria Nikolova, Matthieu Carriere, Mohammad-Ali Jenabian, Sophie Limou, Mehwish Younas, et al.. CD39/Adenosine Pathway Is Involved in AIDS Progression.. PLoS Pathogens, Public Library of Science, 2011, 7 (7), pp.e1002110. ⟨10.1371/journal.ppat.1002110⟩. ⟨inserm-00616754⟩



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