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Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs.

Abstract : Oxidized LDLs (oxLDLs) induce various cellular dysfunctions potentially implicated in the pathogenesis of atherosclerosis. For instance, toxic concentrations of oxLDLs trigger ER stress, autophagy and apoptosis. High-density lipoproteins (HDLs) counteract several adverse biological effects triggered by oxLDLs. Our recent study reveals that HDLs inhibit the activation of ER stress and of autophagy induced by oxLDLs.
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https://www.hal.inserm.fr/inserm-00615490
Contributor : Marie Francoise Simon <>
Submitted on : Friday, August 19, 2011 - 2:53:46 PM
Last modification on : Friday, January 10, 2020 - 9:09:54 PM

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  • HAL Id : inserm-00615490, version 1
  • PUBMED : 21412049

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Carole Muller, Robert Salvayre, Anne Nègre-Salvayre, Cécile Vindis. Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs.. Autophagy, Taylor & Francis, 2011, 7 (5), pp.541-3. ⟨inserm-00615490⟩

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