Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch, Development, vol.121, pp.3637-50, 1995. ,
Nuclear migration during retinal development, Brain Research, vol.1192, pp.29-36, 2008. ,
DOI : 10.1016/j.brainres.2007.05.021
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674389
Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells, Invest Ophthalmol Vis Sci, vol.38, pp.1293-303, 1997. ,
PTF1 Is an Organ-Specific and Notch-Independent Basic Helix-Loop-Helix Complex Containing the Mammalian Suppressor of Hairless (RBP-J) or Its Paralogue, RBP-L, Molecular and Cellular Biology, vol.26, issue.1, pp.117-147, 2006. ,
DOI : 10.1128/MCB.26.1.117-130.2006
Temporal and spatial expression of transcription factors FoxN4, and Lim1 mRNA in the developing chick retina, 2008. ,
Horizontal cell progenitors arrest in G2-phase and undergo terminal mitosis on the vitreal side of the chick retina, Developmental Biology, vol.330, issue.1, pp.105-118, 2009. ,
DOI : 10.1016/j.ydbio.2009.03.013
Math5 is required for retinal ganglion cell and optic nerve formation, Development, vol.128, pp.2497-508, 2001. ,
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window, Genes & Development, vol.23, issue.17, pp.2088-101, 2009. ,
DOI : 10.1101/gad.1800209
Dlx1,Dlx2,Pax6,Brn3b, andChx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina, The Journal of Comparative Neurology, vol.20, issue.2, pp.187-204, 2003. ,
DOI : 10.1002/cne.10674
A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool, Development, vol.134, issue.19, pp.3427-3463, 2007. ,
DOI : 10.1242/dev.005868
Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient, Cell, vol.134, issue.6, pp.1055-65, 2008. ,
DOI : 10.1016/j.cell.2008.07.017
Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas, Genes & Development, vol.22, issue.11, pp.1445-50, 2008. ,
DOI : 10.1101/gad.1663208
Regulation of neuronal diversity in the Xenopus retina by Delta signalling, Nature, vol.385, issue.6611, pp.67-70, 1997. ,
DOI : 10.1038/385067a0
Ptf1a triggers GABAergic neuronal cell fates in the retina, BMC Developmental Biology, vol.7, issue.1, p.110, 2007. ,
DOI : 10.1186/1471-213X-7-110
URL : https://hal.archives-ouvertes.fr/hal-00283597
Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina, Nature Genetics, vol.34, issue.1, pp.53-61, 2003. ,
DOI : 10.1038/ng1144
Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development, Development, vol.131, issue.6, pp.1343-51, 2004. ,
DOI : 10.1242/dev.01018
Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin, BMC Developmental Biology, vol.8, issue.1, p.46, 2008. ,
DOI : 10.1186/1471-213X-8-46
Early identification of retinal subtypes in the developing, pre-laminated chick retina using the transcription factors Prox1, Eur J Histochem, vol.50, pp.147-54, 2006. ,
Mice lacking cyclin D1 are small and show defects in eye and mammary gland development., Genes & Development, vol.9, issue.19, pp.2364-72, 1995. ,
DOI : 10.1101/gad.9.19.2364
Heterogeneity of horizontal cells in the chicken retina, The Journal of Comparative Neurology, vol.41, issue.6, pp.1154-71, 2007. ,
DOI : 10.1002/cne.21236
Chapter 7 Comparative studies on horizontal cells and a note on microglial cells, Progress in Retinal Research, vol.5, pp.165-206, 1986. ,
DOI : 10.1016/0278-4327(86)90010-6
Evidence of three horizontal cells in the chick retina, Jpn.J.Ophtamol, vol.23, pp.378-387, 1979. ,
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn, Development, vol.132, issue.24, pp.5461-5470, 2005. ,
DOI : 10.1242/dev.02167
Elevated levels of cyclin D1 mRNA in the undifferentiated chick retina, Gene, vol.182, issue.1-2, pp.111-116, 1996. ,
DOI : 10.1016/S0378-1119(96)00524-0
Notch signaling regulates regeneration in the avian retina, Developmental Biology, vol.312, issue.1, pp.300-311, 2007. ,
DOI : 10.1016/j.ydbio.2007.09.046
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord, Development, vol.136, issue.17, pp.2945-54, 2009. ,
DOI : 10.1242/dev.035352
Maintenance of neuroepithelial progenitor cells by Delta???Notch signalling in the embryonic chick retina, Current Biology, vol.7, issue.9, pp.661-70, 1997. ,
DOI : 10.1016/S0960-9822(06)00293-4
Differentiation of photoreceptors and horizontal cells in the embryonic mouse retina: An electron microscopic, serial section analysis, The Journal of Comparative Neurology, vol.177, issue.3, pp.495-511, 1979. ,
DOI : 10.1002/cne.901870303
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling, Genes & Development, vol.22, issue.2, pp.166-78, 2008. ,
DOI : 10.1101/gad.1628008
Ptf1a, a bHLH Transcriptional Gene, Defines GABAergic Neuronal Fates in Cerebellum, Neuron, vol.47, issue.2, pp.201-214, 2005. ,
DOI : 10.1016/j.neuron.2005.06.007
Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors, J Virol, vol.61, pp.3004-3016, 1987. ,
Math3 and NeuroD regulate amacrine cell fate specification in the retina, Development, vol.129, pp.831-873, 2002. ,
Notch 1 inhibits photoreceptor production in the developing mammalian retina, Development, vol.133, issue.5, pp.913-936, 2006. ,
DOI : 10.1242/dev.02245
Origin and Determination of Inhibitory Cell Lineages in the Vertebrate Retina, Journal of Neuroscience, vol.31, issue.7, pp.2549-62, 2011. ,
DOI : 10.1523/JNEUROSCI.4713-10.2011
Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina, Neural Development, vol.4, issue.1, p.34, 2009. ,
DOI : 10.1186/1749-8104-4-34
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors, Nature Genetics, vol.32, issue.1, pp.128-162, 2002. ,
DOI : 10.1038/ng959
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas, Genes & Development, vol.12, issue.23, pp.3752-63, 1998. ,
DOI : 10.1101/gad.12.23.3752
The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD, The EMBO Journal, vol.17, issue.5, pp.1412-1434, 1998. ,
DOI : 10.1093/emboj/17.5.1412
URL : https://hal.archives-ouvertes.fr/hal-00379937
Foxn4 Controls the Genesis of Amacrine and Horizontal Cells by Retinal Progenitors, Neuron, vol.43, issue.6, pp.795-807, 2004. ,
DOI : 10.1016/j.neuron.2004.08.041
The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development, Proceedings of the National Academy of Sciences, vol.98, issue.4, pp.1649-54, 2001. ,
DOI : 10.1073/pnas.98.4.1649
Vertebrate neural cell-fate determination: Lessons from the retina, Nature Reviews Neuroscience, vol.15, issue.2, pp.109-127, 2001. ,
DOI : 10.1038/35053522
promotes amacrine cell production in the chick retina, Developmental Neurobiology, vol.264, issue.2-3, pp.88-104, 2009. ,
DOI : 10.1002/dneu.20693
Generating neuronal diversity in the retina: one for nearly all, Trends in Neurosciences, vol.25, issue.1, pp.32-40, 2002. ,
DOI : 10.1016/S0166-2236(00)02028-2
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex, Genes & Development, vol.21, issue.20, pp.2629-2672, 2007. ,
DOI : 10.1101/gad.1575207
Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells, Gastroenterology, vol.139, issue.1, pp.270-80, 2010. ,
DOI : 10.1053/j.gastro.2010.04.003
Transcriptional Autoregulation Controls Pancreatic Ptf1a Expression during Development and Adulthood, Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood, pp.5458-68, 2008. ,
DOI : 10.1128/MCB.00549-08
Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins, Development, vol.128, pp.217-248, 2001. ,
A bHLH transcriptional network regulating the specification of retinal ganglion cells, Development, vol.132, issue.17, pp.3907-3928, 2005. ,
DOI : 10.1242/dev.01960
Multiple Transcriptional Mechanisms Control Ptf1a Levels during Neural Development Including Autoregulation by the PTF1-J Complex, Journal of Neuroscience, vol.29, issue.36, pp.11139-11187, 2009. ,
DOI : 10.1523/JNEUROSCI.2303-09.2009
p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation, CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation, pp.463-73, 2009. ,
DOI : 10.1042/BJ20080293
URL : https://hal.archives-ouvertes.fr/hal-00478971
Involvement of Pleiotrophin in CNTF-mediated differentiation of the late retinal progenitor cells, Developmental Biology, vol.298, issue.2, pp.527-566, 2006. ,
DOI : 10.1016/j.ydbio.2006.07.003
Mutations in PTF1A cause pancreatic and cerebellar agenesis, Nature Genetics, vol.56, issue.12, pp.1301-1306, 2004. ,
DOI : 10.1128/MCB.20.10.3640-3654.2000
Cyclin D1 provides a link between development and oncogenesis in the retina and breast, Cell, vol.82, issue.4, pp.621-651, 1995. ,
DOI : 10.1016/0092-8674(95)90034-9
Regulation of ganglion cell production by notch signaling during retinal development, Journal of Neurobiology, vol.128, issue.3, pp.511-535, 2003. ,
DOI : 10.1002/neu.10156
Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis, Development, vol.136, issue.22, pp.3767-77, 2009. ,
DOI : 10.1242/dev.033449
The Basic Domain of ATH5 Mediates Neuron-Specific Promoter Activity during Retina Development, Molecular and Cellular Biology, vol.25, issue.22, pp.10029-10068, 2005. ,
DOI : 10.1128/MCB.25.22.10029-10039.2005
LIM family transcription factors regulate the subtype-specific morphogenesis of retinal horizontal cells at post-migratory stages, Developmental Biology, vol.330, issue.2, pp.318-346, 2009. ,
DOI : 10.1016/j.ydbio.2009.04.002
Cadherin is required for dendritic morphogenesis and synaptic terminal organization of retinal horizontal cells, Development, vol.133, issue.20, pp.4085-96, 2006. ,
DOI : 10.1242/dev.02566
Requirement for math5 in the development of retinal ganglion cells, Genes & Development, vol.15, issue.1, pp.24-33, 2001. ,
DOI : 10.1101/gad.855301
dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development, Development, vol.133, issue.11, pp.2105-2118, 2006. ,
DOI : 10.1242/dev.02345
Origin of Climbing Fiber Neurons and Their Developmental Dependence on Ptf1a, Journal of Neuroscience, vol.27, issue.41, pp.10924-10958, 2007. ,
DOI : 10.1523/JNEUROSCI.1423-07.2007
Retrovirus-mediated gene expression during chick visual system development, Methods, vol.28, issue.4, pp.396-401, 2002. ,
DOI : 10.1016/S1046-2023(02)00258-X
Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina, Development, vol.133, issue.7, pp.1367-78, 2006. ,
DOI : 10.1242/dev.02311
Cell differentiation in the retina of the mouse, The Anatomical Record, vol.229, issue.2, pp.199-205, 1985. ,
DOI : 10.1002/ar.1092120215
Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates, Developmental Biology, vol.268, issue.1, pp.174-84, 2004. ,
DOI : 10.1016/j.ydbio.2003.12.016
The transcription factor RBP-J is essential for retinal cell differentiation and lamination, Molecular Brain, vol.2, issue.1, p.38, 2009. ,
DOI : 10.1186/1756-6606-2-38
Ptf1a plasmids or not (Control) were harvested, and the expression of exogenous Ptf1a proteins was monitored by western blotting using anti-Ptf1a and anti-HA antibodies. RCAS-Ptf1a-noTag: RCAS-Ptf1a without HA-Tag, RCAS-HA-Ptf1a: RCAS-Ptf1a with HA-tag. (B-E) The RCAS-infected (B-C) and RCASPtf1a- infected (D-E) retinal sections were stained with anti-Ptf1a (B,D) or anti-gag (p27) (C,E) antibodies at E9. (F-Q) The RCAS-infected RCAS-Ptf1a-infected (H-I,L-M,P-Q) retinal sections were co-stained with hemalun, Ptf1a aaects retinal structure. (A) Lysates from DF1 cells transfected with the RCAS- retinal sections were counterstained with DAPI. ONL, outer nuclear layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer; NBL, neuroblastic layer. Bars: 50 m (B-E in B and D), 25 m (F-Q) ,
) retinas were stained with EdU and anti-gag (3c2) antibodies (A-D) or with anti-P-H3 and antigag antibodies (E-H) at E7 and E9. In F, arrows point to P-H3 positive cells in an ectopic location in the RCAS-Ptf1a-infected retinas. (I-J) Quantitative analysis of EdU-positive (I) or P-H3-positive cells (J) among the RCAS-and RCAS-Ptf1a-infected cells at E7 and E9. Values represent the mean ± s.e.m. The percentage of EdU-positive cells among the infected cells was normalized by the percentage of EdU-positive cells among the non-infected cells for each embryo. NBL, neuroblastic layer; GCL, ganglion cell layer ,
RCAS-Ptf1a--C12-infected (D,I,N,S) and RCAS-Ptf1a--basic-infected (E,J,O,T) patches from E12 retinas were immunostained using anti-Brn3a (A-E), anti-Visinin (F-J), anti-Ap2? (K-O), and anti-Prox1 (P-T) antibodies. For clarity, the gag labeling is not represented. Retinal sections were counterstained with DAPI. (U-V) Representative ow cytometry analysis after staining the RCAS-infected (U) and RCAS-Ptf1a-infected (V) dissociated cells with anti-gag (p27) and anti-Visinin antibodies at E12. (W) Quantitative analysis of Visinin-, Ap2?-and Prox1-positive cells among the infected cells at E12. Values represent the mean ± s.e.m of at least four separate eye counts. ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer, p.50 ,
) retinal patches were immunostained using an anti-gag antibody and either anti-Brn3a (A-B), anti-Visinin (CD), anti-Prox1 (E-F) or anti-Ap2? (G-H) antibodies. Cell type-speciic labeling in panels A-H was represented without gag labeling in panels a-h, respectively. (I) Quantitative analysis of Visinin-, Ap2?-or Prox1-positive cells among the infected cells. The values represent the mean ± s.e.m of at least four separate retinal counts and are representative of two independent injections. (J-L) Cells undergoing apoptosis were TUNEL-labeled at E7 in the RCASinfected (J) and RCAS-Ptf1a-infected (K) patches detected using anti-gag (p27) antibody. Sections in J and K were counterstained with DAPI. (L) Quantitative analysis of the number of apoptotic cells per area in the RCAS-and RCAS-Ptf1a-infected patches at E7. The values represent the mean ± s.e.m of at least three separate retinas. NBL, neuroblastic layer; GCL, ganglion cell layer, E7 retinas prior to lamination defects, pp.50-75 ,
Epiiuorescence micrographs show Ptf1a Islet1 (I-L) double-labeling of E6.5, E9, E12 and E16 chick retinas, and the corresponding split uorescence images are to the right of each panel. Insets in b, f, and j are higher magniications of the boxes in B, F and J. Arrows point at double-labeled cells. GCL, ganglion cell layer; INL, inner nuclear layer, Ptf1a expression in subtypes of developing horizontal cells Ptf1a, Lim1 (E-H), and Ptf1a ,
F) patches were double immunostained at E7 with either anti-Lim1 and anti-Prox1 antibodies for H1 cells (A-B), anti- Islet1 and anti-Prox1 antibodies for H2 and H3 cells (C-D) or anti-Islet1 and anti-TrkA antibodies for H3 cells (E-F). a-f are higher magniications of the boxes in A-F, respectively. a'-f' and a''-f'' are split uorescence images of a-f. Arrows point to some double-positive cells. (G-N) The RCAS-infected (G,I,K,M) and RCAS-Ptf1a-infected (H,J,L,N) patches at E9 were double immunostained with either anti-Lim1 and anti-Prox1 (G-H), anti-Islet1 and anti- Prox1 (I-J), anti-Islet1 and anti-TrkA (K-L) or anti-TrkA and anti-Lim1 antibodies (M-N). g-n are higher magniications of boxes in G-N, respectively. g'-n' and g''-n'' are split uorescent images of g-n, respectively. Arrows point to some Islet1-positive/TrkA-negative cells. (O) The quantiication of Lim1, Islet1-(H2-H3) and TrkA-positive (H3) cells among the Prox1-positive HCs in the RCAS-and RCAS-Ptf1a-infected patches at E9. The values represent the mean ± s.e.m. NBL, neuroblastic layer; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer; pHCL, prospective horizontal cell layer. Bars: 25 m (A-F), 5 m, pp.50-60 ,