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Regulation of cell death by sphingosine 1-phosphate lyase.

Abstract : By controlling sphingosine 1-phosphate (S1P) catabolism, S1P lyase (SPL) represents an undeniable candidate as potential regulator of a cancer cell's fate in response to stress. Our recent study reveals that complete loss of SPL activity leads to upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL and consequently protects against apoptosis induced by chemotherapy and nutrient starvation but not against autophagy. Here, we speculate on how S1P and disruption of S1P breakdown may regulate cell death and autophagy.
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Contributor : Marie Francoise Simon Connect in order to contact the contributor
Submitted on : Friday, August 5, 2011 - 5:06:32 PM
Last modification on : Monday, July 4, 2022 - 9:26:59 AM


  • HAL Id : inserm-00613705, version 1
  • PUBMED : 20215862



Sandra Colié, Patrice Codogno, Thierry Levade, Nathalie Andrieu-Abadie. Regulation of cell death by sphingosine 1-phosphate lyase.. Autophagy, Taylor & Francis, 2010, 6 (3), pp.426-7. ⟨inserm-00613705⟩



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