Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.

Abstract : OBJECTIVE: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. METHODS: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. RESULTS: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. INTERPRETATION: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops.
Type de document :
Article dans une revue
Annals of Neurology, Wiley, 2011, 69 (5), pp.793-802. 〈10.1002/ana.22222〉
Liste complète des métadonnées

Littérature citée [52 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00613111
Contributeur : Olivier David <>
Soumis le : lundi 30 janvier 2012 - 14:52:39
Dernière modification le : lundi 24 septembre 2018 - 10:56:03
Document(s) archivé(s) le : mardi 13 décembre 2016 - 19:04:19

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

CEA | U836 | UGA | DRT | LETI

Citation

Brigitte Piallat, Mircea Polosan, Valérie Fraix, Laurent Goetz, Olivier David, et al.. Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.. Annals of Neurology, Wiley, 2011, 69 (5), pp.793-802. 〈10.1002/ana.22222〉. 〈inserm-00613111〉

Partager

Métriques

Consultations de la notice

270