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Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population.

Abstract : ABSTRACT: BACKGROUND: France stands among high risk areas for colorectal cancer. Different trends in CRC incidence are reported around the world. The aim of this study was to provide temporal trends in CRC incidence over a 30-year period in a French well-defined population Patients and Methods: Between 1976 and 2005, 17,028 new cases were registered by the Burgundy digestive cancer registry. The mean variations in age-standardized incidence rates were estimated using a Poisson regression adjusted for age for each gender and location. The cumulative risk by birth cohort of developing a cancer over the age range 0-74 years was estimated using an age-cohort model. RESULTS: Incidence rates increased for right and left colon cancers more rapidly in males (respectively +11.7% and +10.3% on average by 5-year period)than in females (respectively +5.9% and +6.1%). It remained stable for sigmoid cancers in males (-0.1%) and decreased in females (-5.2%). It also decreased for rectal cancers both in males (-2.7%)and in females (-2.0%). The cumulative risk increased from 3.9% for males born around 1900 to 4.9% for those born around 1930 and then slightly decreased (4.5% among those born around 1950. It remained at the same level for females born around 1900 (2.7%) as for those born around 1930 (2.7%) and then slightly increased (2.9%) for those born around 1950. For right colon cancers, the cumulative risk increased strikingly in successive birth cohorts from 0.53% to 1.2% in males and 0.55% to 0.77% in females. The corresponding cumulative risks for the left colon were 0.24% and 0.42% in males and 0.14% and 0.29% in females. For sigmoid cancer, they decreased from 1.59% to 1.08% in males, and 0.88% in females. CONCLUSION: Temporal variations in incidence rates of colorectal cancers vary by subsite, suggesting different aetiological factors and implications for diagnosis and screening strategies.Total colonoscopy must be the preferred strategy in high-risk groups or after a positive faecal occult blood test. Author's contributions: M Chauvenet, J Faivre and AM Bouvier contributed to the study design, data analysis and drafting of the paper, V Jooste to the data analysis and drafting of the paper, V Cottet and C Lepage to the interpretation of the results and drafting of the paper Source of funding: This work was supported by the National Public Health Institute (InVS) and the National Cancer Institute (INCa).
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Submitted on : Tuesday, August 2, 2011 - 6:03:38 PM
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Marion Chauvenet, Vanessa Cottet, Côme Lepage, Valérie Jooste, Jean Faivre, et al.. Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population.. BMC Cancer, BioMed Central, 2011, 11 (1), pp.282. ⟨10.1186/1471-2407-11-282⟩. ⟨inserm-00613110⟩



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