S. Stockholm, 8 Center of Basic Metabolic Research, Faculty of Health Sciences, pp.11-872

A. Herbert, N. Gerry, M. Mcqueen, I. Heid, A. Pfeufer et al., A Common Genetic Variant Is Associated with Adult and Childhood Obesity, Science, vol.312, issue.5771, pp.312279-283, 2006.
DOI : 10.1126/science.1124779

T. Frayling, N. Timpson, M. Weedon, E. Zeggini, R. Freathy et al., A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity, Science, vol.316, issue.5826, pp.316889-894, 2007.
DOI : 10.1126/science.1141634

A. Hinney, T. Nguyen, A. Scherag, S. Friedel, G. Bronner et al., Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants, PLoS ONE, vol.43, issue.3, p.1361, 2007.
DOI : 10.1371/journal.pone.0001361.s003

Y. Liu, X. Liu, L. Wang, C. Dina, H. Yan et al., Genome-wide association scans identified CTNNBL1 as a novel gene for obesity, Human Molecular Genetics, vol.17, issue.12, pp.171803-1813, 2008.
DOI : 10.1093/hmg/ddn072

R. Loos, C. Lindgren, S. Li, E. Wheeler, J. Zhao et al., Common variants near MC4R are associated with fat mass, weight and risk of obesity, Nature Genetics, vol.2, issue.6, pp.40768-775, 2008.
DOI : 10.1086/521580

C. Cotsapas, E. Speliotes, I. Hatoum, D. Greenawalt, R. Dobrin et al., Common body mass indexassociated variants confer risk of extreme obesity, Hum Mol Genet, issue.18, pp.183502-3507, 2009.

D. Meyre, J. Delplanque, J. Chevre, C. Lecoeur, S. Lobbens et al., Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations, Nature Genetics, vol.276, issue.2, pp.41157-159, 2009.
DOI : 10.1016/S0006-291X(02)00379-0

G. Thorleifsson, G. Walters, D. Gudbjartsson, V. Steinthorsdottir, P. Sulem et al., Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity, Nature Genetics, vol.87, issue.1, pp.4118-4142, 2009.
DOI : 10.1038/ng1104-1129

C. Willer, E. Speliotes, R. Loos, S. Li, C. Lindgren et al., Six new loci associated with body Jiao et al. BMC Medical Genomics51 mass index highlight a neuronal influence on body weight regulation, Nat Genet, vol.4, issue.1, pp.51-4125, 2009.

A. Scherag, C. Dina, A. Hinney, V. Vatin, S. Scherag et al., Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups, PLoS Genetics, vol.19, issue.4, p.1000916
DOI : 10.1371/journal.pgen.1000916.s012

E. Speliotes, C. Willer, S. Berndt, K. Monda, G. Thorleifsson et al., Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index, Nature Genetics, vol.74, issue.11
DOI : 10.1016/j.ajhg.2010.02.020

I. Farooqi, Genetic and hereditary aspects of childhood obesity, Best Practice & Research Clinical Endocrinology & Metabolism, vol.19, issue.3, pp.359-374, 2005.
DOI : 10.1016/j.beem.2005.04.004

E. Bochukova, N. Huang, J. Keogh, E. Henning, C. Purmann et al., Large, rare chromosomal deletions associated with severe early-onset obesity, Nature, vol.40, issue.7281, pp.666-670
DOI : 10.1038/nature08689

R. Walters, S. Jacquemont, A. Valsesia, A. De-smith, D. Martinet et al., A new highly penetrant form of obesity due to deletions on chromosome 16p11.2, Nature, vol.30, issue.7281, pp.671-675
DOI : 10.1038/nature08727

M. Hofker and C. Wijmenga, A supersized list of obesity genes, Nature Genetics, vol.41, issue.2, pp.139-140, 2009.
DOI : 10.2337/diabetes.52.4.910

E. Speliotes, C. Willer, S. Berndt, K. Monda, G. Thorleifsson et al., Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index, Nature Genetics, vol.74, issue.11, pp.937-948
DOI : 10.1016/j.ajhg.2010.02.020

J. Fischer, L. Koch, C. Emmerling, J. Vierkotten, T. Peters et al., Inactivation of the Fto gene protects from obesity, Nature, vol.134, issue.7240, pp.458894-898, 2009.
DOI : 10.1038/nature07848

C. Church, S. Lee, E. Bagg, J. Mctaggart, R. Deacon et al., A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene, PLoS Genetics, vol.13, issue.4, p.1000599, 2009.
DOI : 10.1371/journal.pgen.1000599.s016

C. Sandholt, T. Sparso, N. Grarup, A. Albrechtsen, K. Almind et al., Combined Analyses of 20 Common Obesity Susceptibility Variants, Diabetes, vol.59, issue.7, pp.1667-1673
DOI : 10.2337/db09-1042

M. Rolland-cachera, T. Cole, M. Sempe, J. Tichet, C. Rossignol et al., Body Mass Index variations: centiles from birth to 87 years, Eur J Clin Nutr, vol.45, issue.1, pp.13-21, 1991.

B. Dubern, C. Lubrano-berthelier, M. Mencarelli, B. Ersoy, M. Frelut et al., Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the ??-Melanocyte Stimulating Hormone Domain, Pediatric Research, vol.91, issue.2, pp.211-216, 2008.
DOI : 10.1203/PDR.0b013e31815ed62b

C. Simon, B. Schweitzer, M. Oujaa, A. Wagner, D. Arveiler et al., Successful overweight prevention in adolescents by increasing physical activity: a 4-year randomized controlled intervention, Int J Obes, issue.10, pp.321489-1498, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00289629

G. Dolley, S. Bertrais, V. Frochot, J. Bebel, M. Guerre-millo et al., Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study, International Journal of Obesity, vol.14, issue.4, pp.669-675, 2008.
DOI : 10.1194/jlr.M400373-JLR200

Y. Linne, I. Dahlman, and J. Hoffstedt, beta1-Adrenoceptor gene polymorphism predicts long-term changes in body weight, Int J Obes, vol.29, issue.5, pp.458-462, 2005.

S. Kring, C. Holst, E. Zimmermann, J. T. Berentzen, T. Toubro et al., FTO Gene Associated Fatness in Relation to Body Fat Distribution and Metabolic Traits throughout a Broad Range of Fatness, PLoS ONE, vol.57, issue.8, p.2958, 2008.
DOI : 10.1371/journal.pone.0002958.t005

M. Rodbell and K. G. , [7] Preparation of isolated fat cells and fat cell ???ghost???; methods for assaying adenylate cyclase activity and levels of cyclic AMP, Methods Enzymol, pp.31103-114, 1974.
DOI : 10.1016/0076-6879(74)31010-5

P. Arner, B. Stenson, E. Dungner, E. Naslund, J. Hoffstedt et al., Expression of Six Transmembrane Protein of Prostate 2 in Human Adipose Tissue Associates with Adiposity and Insulin Resistance, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.6, pp.932249-2254, 2008.
DOI : 10.1210/jc.2008-0206

S. Purcell, N. B. Todd-brown, K. Thomas, L. Ferreira, M. Bender et al., PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses, The American Journal of Human Genetics, vol.81, issue.3, pp.81559-575, 2007.
DOI : 10.1086/519795

M. Ryden, T. Agustsson, J. Laurencikiene, T. Britton, E. Sjolin et al., Lipolysis-Not inflammation, cell death, or lipogenesis-Is involved in adipose tissue loss in cancer cachexia, Cancer, vol.103, issue.1, pp.1131695-1704, 2008.
DOI : 10.1002/cncr.23802

B. Kaess, T. Barnes, K. Stark, F. Charchar, D. Waterworth et al., FGF21 signalling pathway and metabolic traits ??? genetic association analysis, European Journal of Human Genetics, vol.17, issue.3, pp.211344-1348, 2010.
DOI : 10.1038/ejhg.2010.130

URL : https://hal.archives-ouvertes.fr/hal-00567033

K. Silventoinen and J. Kaprio, Genetics of Tracking of Body Mass Index from Birth to Late Middle Age: Evidence from Twin and Family Studies, Obesity Facts, vol.2, issue.3, 2009.
DOI : 10.1159/000219675

M. Den-hoed, U. Ekelund, S. Brage, A. Grontved, J. Zhao et al., Genetic susceptibility to obesity and related traits in childhood and adolescence; influence of loci identified by genomewide association studies, Diabetes, issue.11, pp.592980-2988, 2010.

C. Andreasen, M. Mogensen, K. Borch-johnsen, A. Sandbaek, T. Lauritzen et al., Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes, PLoS ONE, vol.11, issue.8, p.2872, 2008.
DOI : 10.1371/journal.pone.0002872.t002

C. Vogel, B. Greene, A. Scherag, T. Muller, S. Friedel et al., Non-replication of an association of CTNNBL1polymorphisms and obesity in a population of Central European ancestry, BMC Medical Genetics, vol.41, issue.2, p.14, 2009.
DOI : 10.1038/ng.301

M. Tomas, E. Vazquez, J. Fernandez-fernandez, I. Subirana, C. Plata et al., Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction, J Hypertens, issue.11, pp.262147-2153, 2008.

W. Du, J. Bautista, H. Yang, A. Diez-sampedro, S. You et al., Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder, Nature Genetics, vol.331, issue.7, pp.37733-738, 2005.
DOI : 10.1126/science.1088477

H. Hu, M. He, R. Tao, H. Sun, R. Hu et al., Characterization of ion channels in human preadipocytes, Journal of Cellular Physiology, vol.207, issue.2, pp.427-435, 2009.
DOI : 10.1002/jcp.21617

K. Spalding, E. Arner, P. Westermark, S. Bernard, B. Buchholz et al., Dynamics of fat cell turnover in humans, Nature, issue.7196, pp.453783-787, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00372715