Introduction to resistance to anticancer agents, Oncogene, pp.7262-7264, 2003. ,
DOI : 10.1038/sj.onc.1206932
MULTIDRUG RESISTANCE IN CANCER: ROLE OF ATP-DEPENDENT TRANSPORTERS, Nature Reviews Cancer, vol.2, issue.1, pp.48-58, 2002. ,
DOI : 10.1038/nrc706
Induction of phase I, II and III drug metabolism/transport by xenobiotics, Archives of Pharmacal Research, vol.182, issue.481, pp.249-268, 2005. ,
DOI : 10.1007/BF02977789
The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.3, pp.478-488 ,
DOI : 10.1016/j.bbagen.2006.09.024
Modulation of cytochrome P450 activity: implications for cancer therapy, The Lancet Oncology, vol.6, issue.10, pp.780-789, 2005. ,
DOI : 10.1016/S1470-2045(05)70388-0
SXR, a novel steroid and xenobioticsensing nuclear receptor, Genes & Development, vol.12, issue.20, pp.3195-3205, 1998. ,
DOI : 10.1101/gad.12.20.3195
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module, Mol Pharmacol, vol.56, pp.1329-1339, 1999. ,
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway, Cell, vol.92, issue.1, pp.73-82, 1998. ,
DOI : 10.1016/S0092-8674(00)80900-9
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions., Journal of Clinical Investigation, vol.102, issue.5, pp.1016-1023, 1998. ,
DOI : 10.1172/JCI3703
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides, Biochemical Pharmacology, vol.68, issue.12, pp.2347-2358, 2004. ,
DOI : 10.1016/j.bcp.2004.07.041
Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter, Molecular Pharmacology, vol.64, issue.2, pp.316-324 ,
DOI : 10.1124/mol.64.2.316
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor, Journal of Pharmacology and Experimental Therapeutics, vol.308, issue.2, pp.495-501 ,
DOI : 10.1124/jpet.103.058818
Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive Basseville et al. Molecular Cancer http://www.molecular-cancer.com/content/10/1/80 androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4 alpha United States, In Mol Pharmacol, vol.10, issue.2005, pp.80747-757, 2011. ,
Induction of CYP2C genes in human hepatocytes in primary culture, Drug Metab Dispos, vol.29, pp.242-251, 2001. ,
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor, Mol Pharmacol, vol.60, pp.427-431, 2001. ,
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor United States, Proc Natl Acad Sci, pp.4150-4155 ,
Identification of Pregnane X Receptor Binding Sites in the Regulatory Regions of Genes Involved in Bile Acid Homeostasis, Journal of Molecular Biology, vol.346, issue.2, pp.505-519, 2005. ,
DOI : 10.1016/j.jmb.2004.12.003
Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin, Journal of Biological Chemistry, vol.276, issue.18, pp.14581-14587 ,
DOI : 10.1074/jbc.M010173200
Current therapies for advanced colorectal cancer, Oncology, vol.19, pp.589-595, 2005. ,
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2, Cancer Res, vol.60, pp.1189-1192, 2000. ,
Topoisomerase I inhibitors: camptothecins and beyond, Nature Reviews Cancer, vol.24, issue.10, pp.789-802, 2006. ,
DOI : 10.1038/nrc1977
Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans, Clin Cancer Res, vol.6, pp.2012-2020, 2000. ,
Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38), Molecular Pharmacology, vol.62, issue.3 ,
DOI : 10.1124/mol.62.3.608
ATP- Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P, Mol Pharmacol, vol.55, pp.921-928, 1999. ,
Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats, Cancer Res, vol.57, pp.1934-1938, 1997. ,
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice, Cancer Chemotherapy and Pharmacology, vol.49, issue.4, pp.336-341, 2002. ,
DOI : 10.1007/s00280-001-0420-4
Breast Cancer Resistance Protein Directly Confers SN-38 Resistance of Lung Cancer Cells, Biochemical and Biophysical Research Communications, vol.280, issue.5, pp.1216-1223 ,
DOI : 10.1006/bbrc.2001.4267
Transport of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Breast Cancer Resistance Protein ABCG2 in Human Lung Cancer Cells, Biochemical and Biophysical Research Communications, vol.288, issue.4, pp.827-832 ,
DOI : 10.1006/bbrc.2001.5850
The nuclear receptor superfamily: The second decade, Cell, vol.83, issue.6, pp.835-839 ,
DOI : 10.1016/0092-8674(95)90199-X
Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR, Genes & Development, vol.14, issue.23, pp.3014-3023, 2000. ,
DOI : 10.1101/gad.846800
The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism, Nuclear Receptor Signaling, vol.4, p.1, 2009. ,
DOI : 10.1621/nrs.07001
The Pregnane X Receptor Regulates Gene Expression in a Ligand- and Promoter- Selective Fashion, Molecular Endocrinology, vol.19, issue.5, pp.1170-1180 ,
DOI : 10.1210/me.2004-0434
TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES, Drug Metabolism and Disposition, vol.32, issue.10, pp.1075-1082 ,
DOI : 10.1124/dmd.104.000299
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity, Science, vol.292, issue.5525, pp.2329-2333 ,
DOI : 10.1126/science.1060762
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux, In Nat Med. United States, vol.7, issue.2001, pp.584-590 ,
Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan, Clin Cancer Res, vol.8, pp.2605-2611, 2002. ,
The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells, Molecular Endocrinology, vol.22, issue.4, pp.868-880 ,
DOI : 10.1210/me.2007-0197
Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1745, issue.1, pp.48-58 ,
DOI : 10.1016/j.bbamcr.2005.02.005
Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells, BMC Cancer, vol.71, issue.1, p.3, 2009. ,
DOI : 10.1124/mol.106.029264
Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells, Molecular Endocrinology, vol.20, issue.2, pp.279-290 ,
DOI : 10.1210/me.2005-0205
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.5115
Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen, Drug Metabolism and Disposition, vol.30, issue.5, pp.608-612, 2002. ,
DOI : 10.1124/dmd.30.5.608
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines, Cancer, vol.278, issue.5, pp.957-965, 2007. ,
DOI : 10.1002/cncr.22479
Steroid and Xenobiotic Receptor (SXR) is a Key System for the Acquisition of Cisplatin Resistance in Endometrial Cancer Cells, Journal of International Medical Research, vol.11, issue.2, pp.59-68, 2003. ,
DOI : 10.1177/147323000303100201
Down-Regulation of Pregnane X Receptor Contributes to Cell Growth Inhibition and Apoptosis by Anticancer Agents in Endometrial Cancer Cells, Molecular Pharmacology, vol.72, issue.4, pp.1045-1053 ,
DOI : 10.1124/mol.107.037937
Human Pregnane X Receptor and Resistance to Chemotherapy in Prostate Cancer, Cancer Research, vol.67, issue.21, pp.10361-10367 ,
DOI : 10.1158/0008-5472.CAN-06-4758
Association of Pregnane X Receptor with Multidrug Resistance-Related Protein 3 and its Role in Human Colon Cancer Chemoresistance, Journal of Gastrointestinal Surgery, vol.72, issue.10, pp.1831-1838, 2009. ,
DOI : 10.1007/s11605-009-0964-x
Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR, Journal of Biological Chemistry, vol.276, issue.36, pp.33309-33312 ,
DOI : 10.1074/jbc.C100375200
John's wort induces hepatic drug metabolism through activation of the pregnane X receptor United States, Proc Natl Acad Sci, pp.7500-7502 ,
St John's wort, a herbal antidepressant, activates the steroid X receptor, Journal of Endocrinology, vol.166, issue.3, pp.11-16, 2000. ,
DOI : 10.1677/joe.0.166R011
Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma, Journal of Clinical Oncology, vol.17, issue.5, pp.1516-1525, 1999. ,
DOI : 10.1200/JCO.1999.17.5.1516
Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: A North American Brain Tumor Consortium study, Neuro-Oncology, vol.6, issue.1, pp.44-54, 2004. ,
DOI : 10.1215/S1152851703000292
Molecular Cancer http://www.molecular-cancer.com/content, p.8080, 2011. ,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Analytical Biochemistry, vol.162, issue.1, pp.156-159 ,
DOI : 10.1016/0003-2697(87)90021-2
Real-time quantitative RT???PCR after laser-assisted cell picking, Nature Medicine, vol.12, issue.11, pp.1329-1333, 1998. ,
DOI : 10.1016/0076-6879(93)25039-5
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators, Toxicology and Applied Pharmacology, vol.199, issue.3, pp.251-265 ,
DOI : 10.1016/j.taap.2003.12.027
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening, JNCI Journal of the National Cancer Institute, vol.82, issue.13, pp.1107-1112, 1990. ,
DOI : 10.1093/jnci/82.13.1107