J. Ahmed-choudhury, A. Agathanggelou, S. L. Fenton, C. Ricketts, G. J. Clark et al., Transcriptional Regulation of Cyclin A2 by RASSF1A through the Enhanced Binding of p120E4F to the Cyclin A2 Promoter, Cancer Research, vol.65, issue.7, pp.2690-2697, 2005.
DOI : 10.1158/0008-5472.CAN-04-3593

J. H. Berger and N. Bardeesy, Modeling INK4/ARF Tumor Suppression in the Mouse, Current Molecular Medicine, vol.7, issue.1, pp.63-75, 2007.
DOI : 10.2174/156652407779940477

R. A. Furnari and . Depinho, The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans, Cancer Cell, vol.9, pp.379-390, 2006.

J. Chagraoui, S. L. Niessen, J. Lessard, S. Girard, P. Coulombe et al., E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells, Genes & Development, vol.20, issue.15, pp.2110-2120, 2006.
DOI : 10.1101/gad.1453406

R. Colombo, G. F. Draetta, and S. Chiocca, Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein, Oncogene, vol.22, issue.17, pp.2541-2547, 2003.
DOI : 10.1038/sj.onc.1206379

T. Garrone, K. M. Crook, and . Ryan, DRAM, a p53-induced modulator of autophagy, is critical for apoptosis, Cell, vol.126, pp.121-134, 2006.

G. U. Ellard, Transcription factor HNF1beta and novel partners affect nephrogenesis, Kidney Int, vol.74, pp.210-217, 2008.

C. M. Eischen, J. E. Rehg, S. J. Korsmeyer, and J. L. Cleveland, Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice, Cancer Res, vol.62, pp.2184-2191, 2002.

L. Fajas, C. Paul, A. Vie, S. Estrach, R. Medema et al., Cyclin A Is a Mediator of p120E4F-Dependent Cell Cycle Arrest in G1, Molecular and Cellular Biology, vol.21, issue.8, 2001.
DOI : 10.1128/MCB.21.8.2956-2966.2001

C. Vignais and . Sardet, pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F, Proc Natl Acad Sci, vol.97, pp.7738-7743, 2000.

S. L. Fenton, A. Dallol, A. Agathanggelou, L. Hesson, J. Ahmed-choudhury et al., Identification of the E1A-Regulated Transcription Factor p120E4F as an Interacting Partner of the RASSF1A Candidate Tumor Suppressor Gene, Cancer Research, vol.64, issue.1, pp.102-107, 2004.
DOI : 10.1158/0008-5472.CAN-03-2622

C. Guerra, N. Mijimolle, A. Dhawahir, P. Dubus, M. Barradas et al., Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context, Cancer Cell, vol.4, issue.2, pp.111-120, 2003.
DOI : 10.1016/S1535-6108(03)00191-0

P. Huang, L. Feng, E. A. Oldham, M. J. Keating, and W. Plunkett, Superoxide dismutase as a target for the selective killing of cancer cells, Nature, vol.40710, pp.390-39535030140, 1038.

Q. Huang, Y. T. Wu, H. L. Tan, C. N. Ong, and H. M. Shen, A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress, Cell Death and Differentiation, vol.3, issue.2, pp.264-277, 2009.
DOI : 10.1172/JCI28833

T. Kamijo, F. Zindy, M. F. Roussel, D. E. Quelle, J. R. Downing et al., Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF, Cell, vol.91, issue.5, pp.649-659, 1997.
DOI : 10.1016/S0092-8674(00)80452-3

C. M. Khoo, D. R. Carrasco, M. W. Bosenberg, J. H. Paik, and R. A. Depinho, Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse, Proceedings of the National Academy of Sciences, vol.104, issue.10, pp.3931-39360700093104, 2007.
DOI : 10.1073/pnas.0700093104

W. Y. Kim and N. E. Sharpless, The Regulation of INK4/ARF in Cancer and Aging, Cell, vol.127, issue.2, pp.265-275, 2006.
DOI : 10.1016/j.cell.2006.10.003

W. J. Koopman, L. G. Nijtmans, C. E. Dieteren, P. Roestenberg, F. Valsecchi et al., Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation, Antioxidants & Redox Signaling, vol.12, issue.12, pp.1431-1470, 2009.
DOI : 10.1089/ars.2009.2743

C. Lledo, A. De-bettignies, C. Thepot, K. Deraison, A. Chebli et al., Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis, Proc Natl Acad Sci, vol.107, pp.21076-210811010167107, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00555585

L. Cam, L. , M. Lacroix, M. A. Ciemerych, C. Sardet et al., The E4F Protein Is Required for Mitotic Progression during Embryonic Cell Cycles, Molecular and Cellular Biology, vol.24, issue.14, pp.6467-6475, 2004.
DOI : 10.1128/MCB.24.14.6467-6475.2004

L. Cam, L. , L. K. Linares, C. Paul, E. Julien et al., E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation, Cell, vol.127, issue.4, pp.775-788, 2006.
DOI : 10.1016/j.cell.2006.09.031

K. A. Lee and M. R. Green, A cellular transcription factor E4F1 interacts with an E1a- inducible enhancer and mediates constitutive enhancer function in vitro, Embo J, vol.6, pp.1345-1353, 1987.

. Green, A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters, Proc Natl Acad Sci, vol.84, pp.8355-8359, 1987.

B. Levine and G. Kroemer, Autophagy in the Pathogenesis of Disease, Cell, vol.132, issue.1, pp.27-42, 2008.
DOI : 10.1016/j.cell.2007.12.018

A. H. Lund, G. Turner, A. Trubetskoy, E. Verhoeven, E. Wientjens et al., Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice, Nature Genetics, vol.32, issue.1, pp.160-165, 1038.
DOI : 10.1038/ng956

J. Martin-caballero, J. M. Flores, P. Garcia-palencia, and M. Serrano, Tumor susceptibility of p21(Waf1/Cip1)-deficient mice, Cancer Res, vol.61, pp.6234-6238, 2001.

N. Mizushima, Physiological Functions of Autophagy, Curr Top Microbiol Immunol, vol.33510, pp.71-84978, 1007.
DOI : 10.1007/978-3-642-00302-8_3

V. Nogueira, Y. Park, C. C. Chen, P. Z. Xu, M. L. Chen et al., Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis, Cancer Cell, vol.14, issue.6, 2008.
DOI : 10.1016/j.ccr.2008.11.003

T. Yoda and . Katagiri, Dual roles of smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins, J Biol Chem, vol.285, pp.15577-15586

L. Cam and C. Sardet, The LIM-only protein FHL2 is a negative regulator of E4F1, Oncogene, vol.25, pp.5475-5484, 2006.

D. E. Quelle, F. Zindy, R. A. Ashmun, and C. J. Sherr, Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest, Cell, vol.83, issue.95, pp.993-1000, 1995.

P. Raychaudhuri, R. Rooney, and J. R. Nevins, Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter, Embo J, vol.6, pp.4073-4081, 1987.

. Kefford, Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition, J Biol Chem, vol.278, pp.4981-4989, 2003.

R. J. Rooney, Cell cycle attenuation by p120E4F is accompanied by increased mitotic dysfunction, Cell Growth Differ, vol.12, pp.505-516, 2001.

E. Rui, P. R. Moura, K. A. Goncalves, R. J. Rooney, and J. Kobarg, Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro, Virus Research, vol.115, issue.1, pp.31-42, 2005.
DOI : 10.1016/j.virusres.2005.07.003

D. Sal, p53 is involved in the p120E4F-mediated growth arrest, Oncogene, vol.19, pp.188-199, 2000.

M. Serrano, H. Lee, L. Chin, C. Cordon-cardo, D. Beach et al., Role of the INK4a Locus in Tumor Suppression and Cell Mortality, Cell, vol.85, issue.1, pp.27-37, 1996.
DOI : 10.1016/S0092-8674(00)81079-X

N. E. Sharpless, N. Bardeesy, K. H. Lee, D. Carrasco, D. H. Castrillon et al., Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis, Nature, vol.14, issue.6851, pp.86-91, 1038.
DOI : 10.1038/35092592

L. Struthers, R. Patel, J. Clark, and S. Thomas, Direct Detection of 8-Oxodeoxyguanosine and 8-Oxoguanine by Avidin and Its Analogues, Analytical Biochemistry, vol.255, issue.1, pp.20-31, 1998.
DOI : 10.1006/abio.1997.2354

C. Sundstrom and K. Nilsson, Establishment and characterization of a human histiocytic lymphoma cell line (U-937), International Journal of Cancer, vol.237, issue.5, pp.565-577, 1976.
DOI : 10.1002/ijc.2910170504

. Kroemer, Regulation of autophagy by cytoplasmic p53, Nat Cell Biol, vol.10, pp.676-687, 2004.

D. Trachootham, H. Zhang, W. Zhang, L. Feng, M. Du et al., Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism, Blood, vol.112, issue.5, pp.1912-1922, 2008.
DOI : 10.1182/blood-2008-04-149815

R. B. Achanta, J. Arlinghaus, P. Liu, and . Huang, Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by betaphenylethyl isothiocyanate, Cancer Cell, vol.10, pp.241-252, 2006.

M. Valko, D. Leibfritz, J. Moncol, M. T. Cronin, M. Mazur et al., Free radicals and antioxidants in normal physiological functions and human disease, The International Journal of Biochemistry & Cell Biology, vol.39, issue.1, pp.44-84, 2007.
DOI : 10.1016/j.biocel.2006.07.001

K. H. Vousden and K. M. Ryan, p53 and metabolism, Nature Reviews Cancer, vol.40, issue.10, 2009.
DOI : 10.1038/nrc2715

Y. Xu, S. O. Kim, Y. Li, and J. Han, Autophagy Contributes to Caspase-independent Macrophage Cell Death, Journal of Biological Chemistry, vol.281, issue.28, pp.19179-19187, 2006.
DOI : 10.1074/jbc.M513377200

H. Zhu, L. Zhang, K. Itoh, M. Yamamoto, D. Ross et al., Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress, Free Radical Biology and Medicine, vol.41, issue.1, 2006.
DOI : 10.1016/j.freeradbiomed.2006.03.020