N. J. Anthis, K. L. Wegener, F. Ye, C. Kim, B. T. Goult et al., The structure of an integrin/talin complex reveals the basis of inside-out signal transduction, The EMBO Journal, vol.374, issue.22, pp.3623-3655, 2009.
DOI : 10.1016/j.molcel.2009.02.022

C. G. Bellows, J. Sodek, K. L. Yao, and J. E. Aubin, Phenotypic differences in subclones and long-term cultures of clonally derived rat bone cell lines, Journal of Cellular Biochemistry, vol.224, issue.2, pp.153-69, 1986.
DOI : 10.1002/jcb.240310207

A. Bentmann, N. Kawelke, D. Moss, H. Zentgraf, Y. Bala et al., Circulating Fibronectin Affects Bone Matrix While Osteoblast Fibronectin Modulates Osteoblast Function, Journal of Bone and Mineral Research, 2009.
DOI : 10.1359/jbmr.091011

D. Bouvard, A. Aszodi, G. Kostka, M. R. Block, C. Albiges?rizo et al., Defective osteoblast function in ICAP-1-deficient mice, Development, vol.134, issue.14, pp.2615-2640, 2007.
DOI : 10.1242/dev.000877
URL : https://hal.archives-ouvertes.fr/inserm-00166116

D. Bouvard, C. Brakebusch, E. Gustafsson, A. Aszodi, T. Bengtsson et al., Functional Consequences of Integrin Gene Mutations in Mice, Circulation Research, vol.89, issue.3, pp.211-234, 2001.
DOI : 10.1161/hh1501.094874

D. Bouvard, A. Millon?fremillon, S. Dupe?manet, M. R. Block, and C. Albiges?rizo, Unraveling ICAP-1 function: Toward a new direction?, European Journal of Cell Biology, vol.85, issue.3-4, pp.275-82, 2006.
DOI : 10.1016/j.ejcb.2005.10.005
URL : https://hal.archives-ouvertes.fr/inserm-00166352

D. Bouvard, A. Molla, and M. R. Block, Calcium/calmodulin?dependent protein kinase II controls alpha5beta1 integrin?mediated inside?out signaling, J Cell Sci, vol.111, pp.657-65, 1998.
DOI : 10.1006/bbrc.1998.9592

D. Bouvard, L. Vignoud, S. Dupe?manet, N. Abed, H. N. Fournier et al., Disruption of Focal Adhesions by Integrin Cytoplasmic Domain-associated Protein-1??, Journal of Biological Chemistry, vol.278, issue.8, pp.6567-74, 2003.
DOI : 10.1074/jbc.M211258200

C. Brakebusch, R. Grose, F. Quondamatteo, A. Ramirez, J. L. Jorcano et al., Skin and hair follicle integrity is crucially dependent on ??1 integrin expression on keratinocytes, The EMBO Journal, vol.96, issue.15, pp.3990-4003, 2000.
DOI : 10.1093/emboj/19.15.3990

D. D. Chang, B. Q. Hoang, J. Liu, and T. A. Springer, Molecular Basis for Interaction between Icap1?? PTB Domain and ??1 Integrin, Journal of Biological Chemistry, vol.277, issue.10, pp.8140-8145, 2002.
DOI : 10.1074/jbc.M109031200

D. D. Chang, C. Wong, H. Smith, and J. Liu, Integrin, The Journal of Cell Biology, vol.161, issue.5, pp.1149-57, 1997.
DOI : 10.1006/bbrc.1995.2285

H. Chiba, N. Sawada, T. Ono, S. Ishii, and M. Mori, Establishment and Characterization of a Simian Virus 40-Immortalized Osteoblastic Cell Line from Normal Human Bone, Japanese Journal of Cancer Research, vol.5, issue.3, pp.290-297, 1993.
DOI : 10.1111/j.1349-7006.1993.tb02869.x

E. Cukierman, R. Pankov, D. R. Stevens, and K. M. Yamada, Taking Cell-Matrix Adhesions to the Third Dimension, Science, vol.294, issue.5547, pp.1708-1720, 2001.
DOI : 10.1126/science.1064829

A. Czuchra, H. Meyer, K. R. Legate, C. Brakebusch, and R. Fässler, Genetic analysis of ??1 integrin ???activation motifs??? in mice, The Journal of Cell Biology, vol.51, issue.6, pp.889-99, 2006.
DOI : 10.1038/ncb1136

S. L. Dallas, P. Sivakumar, C. J. Jones, Q. Chen, D. M. Peters et al., Fibronectin Regulates Latent Transforming Growth Factor-?? (TGF??) by Controlling Matrix Assembly of Latent TGF??-binding Protein-1, Journal of Biological Chemistry, vol.280, issue.19, pp.18871-80, 2005.
DOI : 10.1074/jbc.M410762200

J. J. Dowling, A. P. Vreede, S. Kim, J. Golden, and E. L. Feldman, Kindlin-2 is required for myocyte elongation and is essential for myogenesis, BMC Cell Biology, vol.9, issue.1, p.36, 2008.
DOI : 10.1186/1471-2121-9-36
URL : http://doi.org/10.1186/1471-2121-9-36

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, Matrix Elasticity Directs Stem Cell Lineage Specification, Cell, vol.126, issue.4, pp.677-89, 2006.
DOI : 10.1016/j.cell.2006.06.044
URL : http://doi.org/10.1016/j.cell.2006.06.044

M. G. Ensenberger, D. S. Annis, and D. F. Mosher, Actions of the functional upstream domain of protein F1 of Streptococcus pyogenes on the conformation of fibronectin, Biophysical Chemistry, vol.112, issue.2-3, pp.201-208, 2004.
DOI : 10.1016/j.bpc.2004.07.020

M. G. Ensenberger, B. R. Tomasini?johansson, J. Sottile, V. Ozeri, E. Hanski et al., Specific Interactions between F1 Adhesin of Streptococcus pyogenes and N-terminal Modules of Fibronectin, Journal of Biological Chemistry, vol.276, issue.38, pp.35606-35619, 2001.
DOI : 10.1074/jbc.M105417200

R. Fässler, M. Pfaff, J. Murphy, A. A. Noegel, S. Johansson et al., Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts, The Journal of Cell Biology, vol.128, issue.5, pp.979-88, 1995.
DOI : 10.1083/jcb.128.5.979

L. Fontana, Y. Chen, P. Prijatelj, T. Sakai, R. Fässler et al., Fibronectin is required for integrin ??v??6-mediated activation of latent TGF-?? complexes containing LTBP-1, The FASEB Journal, vol.19, issue.13, pp.1798-808, 2005.
DOI : 10.1096/fj.05-4134com

F. G. Giancotti and E. Ruoslahti, Integrin Signaling, Science, vol.285, issue.5430, pp.1028-1060, 1999.
DOI : 10.1126/science.285.5430.1028

R. K. Globus, S. B. Doty, J. C. Lull, E. Holmuhamedov, M. J. Humphries et al., Fibronectin is a survival factor for differentiated osteoblasts, J Cell Sci, vol.111, pp.1385-93, 1998.

J. A. Green, A. L. Berrier, R. Pankov, and K. M. Yamada, ??1 Integrin Cytoplasmic Domain Residues Selectively Modulate Fibronectin Matrix Assembly and Cell Spreading through Talin and Akt-1, Journal of Biological Chemistry, vol.284, issue.12, pp.8148-59, 2009.
DOI : 10.1074/jbc.M805934200
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658108

M. Grunert, C. Dombrowski, M. Sadasivam, K. Manton, S. M. Cool et al., Isolation of a native osteoblast matrix with a specific affinity for BMP2, Journal of Molecular Histology, vol.281, issue.5, pp.393-404, 2007.
DOI : 10.1007/s10735-007-9119-0

B. K. Hall and T. Miyake, All for one and one for all: condensations and the initiation of skeletal development, BioEssays, vol.89, issue.2, pp.138-185, 2000.
DOI : 10.1002/(SICI)1521-1878(200002)22:2<138::AID-BIES5>3.0.CO;2-4

Z. Hamidouche, O. Fromigue, J. Ringe, T. Haupl, P. Vaudin et al., Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis, Bone, vol.44, pp.18587-91, 2009.
DOI : 10.1016/j.bone.2009.03.058

G. Huang, Y. Zhang, B. Kim, G. Ge, D. S. Annis et al., Fibronectin Binds and Enhances the Activity of Bone Morphogenetic Protein 1, Journal of Biological Chemistry, vol.284, issue.38, pp.25879-88, 2009.
DOI : 10.1074/jbc.M109.024125

P. E. Hughes, F. Diaz?gonzalez, L. Leong, C. Wu, J. A. Mcdonald et al., Breaking the integrin hinge. A defined structural constraint regulates integrin signaling, J Biol Chem, vol.271, pp.6571-6575, 1996.

R. O. Hynes, Integrins: Versatility, modulation, and signaling in cell adhesion, Cell, vol.69, issue.1, pp.11-25, 1992.
DOI : 10.1016/0092-8674(92)90115-S

R. O. Hynes, The Extracellular Matrix: Not Just Pretty Fibrils, Science, vol.326, issue.5957, pp.1216-1225, 2009.
DOI : 10.1126/science.1176009

R. O. Hynes, E. L. George, E. N. Georges, J. L. Guan, H. Rayburn et al., Toward a Genetic Analysis of Cell-Matrix Adhesion, Cold Spring Harbor Symposia on Quantitative Biology, vol.57, issue.0, pp.249-58, 1992.
DOI : 10.1101/SQB.1992.057.01.030

Y. Lad, D. S. Harburger, and D. A. Calderwood, Integrin Cytoskeletal Interactions, Methods Enzymol, vol.426, pp.69-84, 2007.
DOI : 10.1016/S0076-6879(07)26004-5

H. Larjava, E. F. Plow, and C. Wu, Kindlins: essential regulators of integrin signalling and cell???matrix adhesion, EMBO reports, vol.1692, issue.12, pp.1203-1211, 2008.
DOI : 10.1074/jbc.M512107200

F. Lecanda, P. M. Warlow, S. Sheikh, F. Furlan, T. H. Steinberg et al., Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction, The Journal of Cell Biology, vol.114, issue.4, pp.931-975, 2000.
DOI : 10.1359/jbmr.1998.13.2.218
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169447

Y. Q. Ma, J. Qin, C. Wu, and E. F. Plow, integrins, The Journal of Cell Biology, vol.1637, issue.3, pp.439-485, 2008.
DOI : 10.1083/jcb.200303120

A. C. Mackinnon, H. Qadota, K. R. Norman, D. G. Moerman, and B. D. Williams, C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes, Current Biology, vol.12, issue.10, pp.787-97, 2002.
DOI : 10.1016/S0960-9822(02)00810-2

R. Manabe, K. Tsutsui, T. Yamada, M. Kimura, I. Nakano et al., Transcriptome-based systematic identification of extracellular matrix proteins, Proceedings of the National Academy of Sciences, vol.105, issue.35, pp.12849-54, 2008.
DOI : 10.1073/pnas.0803640105

A. Mansukhani, P. Bellosta, M. Sahni, and C. Basilico, Signaling by Fibroblast Growth Factors (Fgf) and Fibroblast Growth Factor Receptor 2 (Fgfr2)???Activating Mutations Blocks Mineralization and Induces Apoptosis in Osteoblasts, The Journal of Cell Biology, vol.15, issue.6, pp.1297-308, 2000.
DOI : 10.1093/hmg/6.10.1647

B. Margosio, D. Marchetti, V. Vergani, R. Giavazzi, M. Rusnati et al., Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2, Blood, vol.102, issue.13, pp.4399-406, 2003.
DOI : 10.1182/blood-2003-03-0893

V. Martel, C. Racaud?sultan, S. Dupe, C. Marie, F. Paulhe et al., Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides, Journal of Biological Chemistry, vol.276, issue.24, pp.21217-21244, 2001.
DOI : 10.1074/jbc.M102373200

K. Matsuo, Cross-talk among bone cells, Current Opinion in Nephrology and Hypertension, vol.18, issue.4, pp.292-299, 2009.
DOI : 10.1097/MNH.0b013e32832b75f1

L. M. Maurer, B. R. Tomasini?johansson, W. Ma, D. S. Annis, N. L. Eickstaedt et al., Extended Binding Site on Fibronectin for the Functional Upstream Domain of Protein F1 of Streptococcus pyogenes, Journal of Biological Chemistry, vol.285, issue.52, pp.41087-99, 2010.
DOI : 10.1074/jbc.M110.153692

R. Mcbeath, D. M. Pirone, C. M. Nelson, K. Bhadriraju, and C. S. Chen, Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment, Developmental Cell, vol.6, issue.4, pp.483-95, 2004.
DOI : 10.1016/S1534-5807(04)00075-9

A. Meves, C. Stremmel, K. Gottschalk, and R. Fässler, The Kindlin protein family: new members to the club of focal adhesion proteins, Trends in Cell Biology, vol.19, issue.10, pp.504-517, 2009.
DOI : 10.1016/j.tcb.2009.07.006

A. Millon?fremillon, D. Bouvard, A. Grichine, S. Manet?dupe, M. R. Block et al., -integrin affinity, The Journal of Cell Biology, vol.115, issue.2, pp.427-468, 2008.
DOI : 10.1074/jbc.274.1.11
URL : https://hal.archives-ouvertes.fr/inserm-00166352

E. Montanez, S. Ussar, M. Schifferer, M. Bosl, R. Zent et al., Kindlin-2 controls bidirectional signaling of integrins, Genes & Development, vol.22, issue.10, pp.1325-1355, 2008.
DOI : 10.1101/gad.469408

M. Moser, M. Bauer, S. Schmid, R. Ruppert, S. Schmidt et al., Kindlin-3 is required for ??2 integrin???mediated leukocyte adhesion to endothelial cells, Nature Medicine, vol.7, issue.3, pp.300-305, 2009.
DOI : 10.1073/pnas.0402937101

M. Moser, B. Nieswandt, S. Ussar, M. Pozgajova, and R. Fässler, Kindlin-3 is essential for integrin activation and platelet aggregation, Nature Medicine, vol.128, issue.3, pp.325-355, 2008.
DOI : 10.1038/nm1722

A. M. Moursi, C. H. Damsky, J. Lull, D. Zimmerman, S. B. Doty et al., Fibronectin regulates calvarial osteoblast differentiation, J Cell Sci, vol.109, pp.1369-80, 1996.

A. M. Moursi, R. K. Globus, and C. H. Damsky, Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro, J Cell Sci, vol.110, pp.2187-96, 1997.

R. Pankov, E. Cukierman, B. Z. Katz, K. Matsumoto, D. C. Lin et al., Integrin Dynamics and Matrix Assembly, The Journal of Cell Biology, vol.112, issue.5, pp.1075-90, 2000.
DOI : 10.1083/jcb.141.2.539

J. A. Phillips, E. A. Almeida, E. L. Hill, J. I. Aguirre, M. F. Rivera et al., Role for ??1 integrins in cortical osteocytes during acute musculoskeletal disuse, Matrix Biology, vol.27, issue.7, pp.609-627, 2008.
DOI : 10.1016/j.matbio.2008.05.003

A. J. Potocnik, C. Brakebusch, and R. Fässler, Fetal and Adult Hematopoietic Stem Cells Require ??1 Integrin Function for Colonizing Fetal Liver, Spleen, and Bone Marrow, Immunity, vol.12, issue.6, pp.653-63, 2000.
DOI : 10.1016/S1074-7613(00)80216-2

F. Ramirez and D. B. Rifkin, Extracellular microfibrils: contextual platforms for TGF?? and BMP signaling, Current Opinion in Cell Biology, vol.21, issue.5, pp.616-638, 2009.
DOI : 10.1016/j.ceb.2009.05.005

E. E. Robinson, R. A. Foty, and S. A. Corbett, Fibronectin Matrix Assembly Regulates ??5??1-mediated Cell Cohesion, Molecular Biology of the Cell, vol.15, issue.3, pp.973-81, 2004.
DOI : 10.1091/mbc.E03-07-0528
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC363054

T. Rozario and D. W. Desimone, The extracellular matrix in development and morphogenesis: A dynamic view, Developmental Biology, vol.341, issue.1, 2009.
DOI : 10.1016/j.ydbio.2009.10.026

T. Sakai, K. J. Johnson, M. Murozono, K. Sakai, M. A. Magnuson et al., Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin? wound healing and hemostasis, Nature Medicine, vol.7, issue.3, pp.324-354, 2001.
DOI : 10.1038/85471

T. Sakai, Q. Zhang, R. Fässler, and D. F. Mosher, Modulation of ??1A Integrin Functions by Tyrosine Residues in the ??1 Cytoplasmic Domain, The Journal of Cell Biology, vol.110, issue.2, pp.527-565, 1998.
DOI : 10.1091/mbc.8.8.1415

P. Salmenpera, E. Kankuri, J. Bizik, V. Siren, I. Virtanen et al., Formation and activation of fibroblast spheroids depend on fibronectin???integrin interaction, Experimental Cell Research, vol.314, issue.19, pp.3444-52, 2008.
DOI : 10.1016/j.yexcr.2008.09.004

J. E. Schwarzbauer, Identification of the fibronectin sequences required for assembly of a fibrillar matrix, The Journal of Cell Biology, vol.113, issue.6, pp.1463-73, 1991.
DOI : 10.1083/jcb.113.6.1463

F. Shi, J. Harman, K. Fujiwara, and J. Sottile, Collagen I matrix turnover is regulated by fibronectin polymerization, AJP: Cell Physiology, vol.298, issue.5, 2010.
DOI : 10.1152/ajpcell.00341.2009

J. Sottile and D. C. Hocking, Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions, Molecular Biology of the Cell, vol.13, issue.10, pp.3546-59, 2002.
DOI : 10.1091/mbc.E02-01-0048

J. P. Stains and R. Civitelli, Cell-cell interactions in regulating osteogenesis and osteoblast function, Birth Defects Research Part C: Embryo Today: Reviews, vol.26, issue.1, pp.72-80, 2005.
DOI : 10.1002/bdrc.20034

F. Stanchi, C. Grashoff, C. F. Nguemeni-yonga, D. Grall, R. Fässler et al., Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation, Journal of Cell Science, vol.122, issue.11, pp.1800-1811, 2009.
DOI : 10.1242/jcs.044602
URL : https://hal.archives-ouvertes.fr/hal-00435696

P. J. Stroeken, B. Alvarez, J. Van-rheenen, Y. M. Wijnands, D. Geerts et al., Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane, Journal of Cellular Physiology, vol.10, issue.3, pp.620-628, 2006.
DOI : 10.1002/jcp.20699

B. R. Tomasini?johansson, N. R. Kaufman, M. G. Ensenberger, V. Ozeri, E. Hanski et al., A 49-Residue Peptide from Adhesin F1 of Streptococcus pyogenes Inhibits Fibronectin Matrix Assembly, Journal of Biological Chemistry, vol.276, issue.26, pp.23430-23439, 2001.
DOI : 10.1074/jbc.M103467200

S. Ussar, M. Moser, M. Widmaier, E. Rognoni, C. Harrer et al., Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction, PLoS Genetics, vol.103, issue.12, p.1000289, 2008.
DOI : 10.1371/journal.pgen.1000289.s011

V. Vouret?craviari, E. Boulter, D. Grall, C. Matthews, and E. Van-obberghen?schilling, ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells, Journal of Cell Science, vol.117, issue.19, pp.4559-69, 2004.
DOI : 10.1242/jcs.01331
URL : https://hal.archives-ouvertes.fr/hal-00322356

L. Wang, G. Zhao, R. Olivares?navarrete, B. F. Bell, M. Wieland et al., Integrin ??1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3, Biomaterials, vol.27, issue.20, pp.3716-3741, 2006.
DOI : 10.1016/j.biomaterials.2006.02.022

G. Xiao, D. Wang, M. D. Benson, G. Karsenty, and R. T. Franceschi, Role of the alpha 2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor, Journal of Biological Chemistry, vol.273, issue.49, pp.32988-94, 1998.
DOI : 10.1074/jbc.273.49.32988

A. Yoneda, D. Ushakov, H. A. Multhaupt, and J. R. Couchman, Fibronectin Matrix Assembly Requires Distinct Contributions from Rho Kinases I and -II, Molecular Biology of the Cell, vol.18, issue.1, pp.66-75, 2007.
DOI : 10.1091/mbc.E06-08-0684
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751322

E. Zamir, B. Z. Katz, S. Aota, K. M. Yamada, B. Geiger et al., Molecular diversity of cell? matrix adhesions, J Cell Sci, vol.112, pp.1655-69, 1999.

Q. Zhang, W. J. Checovich, D. M. Peters, R. M. Albrecht, and D. F. Mosher, Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid, The Journal of Cell Biology, vol.127, issue.5, pp.1447-59, 1994.
DOI : 10.1083/jcb.127.5.1447

X. A. Zhang and M. E. Hemler, Interaction of the Integrin ??1 Cytoplasmic Domain with ICAP-1 Protein, Journal of Biological Chemistry, vol.274, issue.1, pp.11-20, 1999.
DOI : 10.1074/jbc.274.1.11

C. Zhong, M. Chrzanowska?wodnicka, J. Brown, A. Shaub, A. M. Belkin et al., Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly, The Journal of Cell Biology, vol.8, issue.2, pp.539-51, 1998.
DOI : 10.1091/mbc.8.11.2329

X. Zhou, R. G. Rowe, N. Hiraoka, J. P. George, D. Wirtz et al., Fibronectin fibrillogenesis regulates three-dimensional neovessel formation, Genes & Development, vol.22, issue.9, pp.1231-1274, 2008.
DOI : 10.1101/gad.1643308
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335318

D. Zimmerman, F. Jin, P. Leboy, S. Hardy, and C. Damsky, Impaired Bone Formation in Transgenic Mice Resulting from Altered Integrin Function in Osteoblasts, Developmental Biology, vol.220, issue.1, pp.2-15, 2000.
DOI : 10.1006/dbio.2000.9633