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Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.: TRAIL - A deadly DISCussion

Abstract : The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.
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https://www.hal.inserm.fr/inserm-00609574
Contributor : Olivier Micheau <>
Submitted on : Tuesday, July 19, 2011 - 2:29:00 PM
Last modification on : Wednesday, June 10, 2020 - 2:06:49 PM
Long-term archiving on: : Thursday, March 30, 2017 - 1:24:06 PM

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  • HAL Id : inserm-00609574, version 1
  • PUBMED : 21756247

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Sarah Shirley, Alexandre Morizot, Olivier Micheau. Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.: TRAIL - A deadly DISCussion. Recent Pat Anticancer Drug Discov, 2011, 6 (3), pp.311-23. ⟨inserm-00609574⟩

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