LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs.

Anne-Sophie Lequarré; Leif Andersson; Catherine André; Merete Fredholm; Christophe Hitte; Tosso Leeb; Hannes Lohi; Kerstin Lindblad-Toh; Michel Georges

doi:10.1016/j.tvjl.2011.06.013

LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs.

Anne-Sophie Lequarré ^{1, *} Leif Andersson ² Catherine André ³ Merete Fredholm ⁴ Christophe Hitte ³ Tosso Leeb ⁵ Hannes Lohi ⁶ Kerstin Lindblad-Toh ^{2, 7} Michel Georges ¹

* Auteur correspondant

1 GIGA-Research - Groupe Interdisciplinaire de Génoprotéomique Appliquée

2 Science for Life Laboratory

3 IGDR - Institut de Génétique et Développement de Rennes

4 Faculty of Life Sciences, Division of Genetics and Bioinformatics

5 Institute of Genetics

6 Folkhälsan Institute of Genetics

7 BROAD INSTITUTE - Broad Institute of MIT and Harvard

Abstract : The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.

Keywords : Canine Inherited disorders Genetics LUPA Single nucleotide polymorphism arrays

Type de document :

Article dans une revue

The Veterinary Journal, Elsevier, 2011, 189 (2), pp.155-9. 〈10.1016/j.tvjl.2011.06.013〉

Domaine :

Sciences du Vivant [q-bio] / Génétique

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00609154
Contributeur : Hervé De Villemeur <>
Soumis le : lundi 18 juillet 2011 - 13:47:01
Dernière modification le : vendredi 14 septembre 2018 - 14:30:03

LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs.

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LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs.

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