Skip to Main content Skip to Navigation
Journal articles

Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound.

Jérôme Gateau 1, 2, * Jean-François Aubry 1, 2 Mathieu Pernot 1, 2 Mathias Fink 2 Mickaël Tanter 1, 2 
* Corresponding author
1 Physique des ondes pour la médecine
ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, INSERM - Institut National de la Santé et de la Recherche Médicale : U979, CNRS - Centre National de la Recherche Scientifique : UMR7587
Abstract : The activation of natural gas nuclei to induce larger bubbles is possible using short ultrasonic excitations of high amplitude, and is required for ultrasound cavitation therapies. However, little is known about the distribution of nuclei in tissues. Therefore, the acoustic pressure level necessary to generate bubbles in a targeted zone and their exact location are currently difficult to predict. To monitor the initiation of cavitation activity, a novel all-ultrasound technique sensitive to single nucleation events is presented here. It is based on combined passive detection and ultrafast active imaging over a large volume using the same multi-element probe. Bubble nucleation was induced using a focused transducer (660 kHz, f-number = 1) driven by a high-power electric burst (up to 300 W) of one to two cycles. Detection was performed with a linear array (4 to 7 MHz) aligned with the single-element focal point. In vitro experiments in gelatin gel and muscular tissue are presented. The synchronized passive detection enabled radio-frequency data to be recorded, comprising high-frequency coherent wave fronts as signatures of the acoustic emissions linked to the activation of the nuclei. Active change detection images were obtained by subtracting echoes collected in the unnucleated medium. These indicated the appearance of stable cavitating regions. Because of the ultrafast frame rate, active detection occurred as quickly as 330 μs after the high-amplitude excitation and the dynamics of the induced regions were studied individually.
Document type :
Journal articles
Complete list of metadata
Contributor : Jérôme Gateau Connect in order to contact the contributor
Submitted on : Sunday, July 10, 2011 - 4:55:44 PM
Last modification on : Sunday, June 26, 2022 - 2:18:30 AM
Long-term archiving on: : Sunday, December 4, 2016 - 6:25:53 AM


Files produced by the author(s)



Jérôme Gateau, Jean-François Aubry, Mathieu Pernot, Mathias Fink, Mickaël Tanter. Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound.. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers, 2011, 58 (3), pp.517-32. ⟨10.1109/TUFFC.2011.1836⟩. ⟨inserm-00607669⟩



Record views


Files downloads