Abnormal functional lateralization and activity of language brain areas in typical specific language impairment (developmental dysphasia) - Archive ouverte HAL Access content directly
Journal Articles Brain - A Journal of Neurology Year : 2011

Abnormal functional lateralization and activity of language brain areas in typical specific language impairment (developmental dysphasia)

(1, 2, 3) , (2) , (2) , (2, 4) , (4) , (2) , (4) , (3) , (5)
1
2
3
4
5

Abstract

Atypical functional lateralization and specialization for language have been proposed to account for developmental language disorders, yet results from functional neuroimaging studies are sparse and inconsistent. This functional magnetic resonance imaging study compared children with a specific subtype of specific language impairment affecting structural language (n = 21), to a matched group of typically developing children using a panel of four language tasks neither requiring reading nor metalinguistic skills, including two auditory lexico-semantic tasks (category fluency and responsive naming) and two visual phonological tasks based on picture naming. Data processing involved normalizing the data with respect to a matched pairs paediatric template, groups and between-groups analysis, and laterality indices assessment within regions of interest using single and combined task analysis. Children with specific language impairment exhibited a significant lack of left lateralization in all core language regions (inferior frontal gyrus-opercularis, inferior frontal gyrus-triangularis, supramarginal gyrus and superior temporal gyrus), across single or combined task analysis, but no difference of lateralization for the rest of the brain. Between-group comparisons revealed a left hypoactivation of Wernicke's area at the posterior superior temporal/supramarginal junction during the responsive naming task, and a right hyperactivation encompassing the anterior insula with adjacent inferior frontal gyrus and the head of the caudate nucleus during the first phonological task. This study thus provides evidence that this subtype of specific language impairment is associated with atypical lateralization and functioning of core language areas.
Fichier principal
Vignette du fichier
2011 Abnormal functional lateral and activity dysphasia, Authors version.pdf (781.46 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00607180 , version 1 (01-02-2016)

Identifiers

Cite

Clément de Guibert, Camille Maumet, Pierre Jannin, Jean-Christophe Ferré, Catherine Tréguier, et al.. Abnormal functional lateralization and activity of language brain areas in typical specific language impairment (developmental dysphasia). Brain - A Journal of Neurology , 2011, 134 (Pt 10), pp.3044-58. ⟨10.1093/brain/awr141⟩. ⟨inserm-00607180⟩
432 View
542 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More