IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo.

Abstract : The L-phenylalanine oxidase IL4I1 inhibits T-cell proliferation in vitro through H(2) O(2) production, and is highly expressed in tumor-associated macrophages. IL4I1 is also detected by immunohistochemistry in neoplastic cells from several B-cell lymphomas and some non-lymphoid tumors. To evaluate IL4I1's effect on tumor growth, we developed a mouse melanoma model constitutively coexpressing IL4I1 and the GP33 epitope. After GP33 vaccination, tumors developed more frequently in mice injected with IL4I1-expressing cells in comparison with mice receiving control cells. Tumor escape was preceded by a rapid diminution of IFN-γ-producing cytotoxic antitumor CD8(+) T cells. Moreover, tumor incidence was already increased when only 20% of the injected cells expressed IL4I1. The minimal IL4I1 activities leading to tumor escape were close to those detected in human melanoma and mesothelioma. Thus, we demonstrate the immunosuppressive functions of IL4I1 in vivo and suggest that IL4I1 facilitates human tumor growth by inhibiting the CD8(+) antitumor T-cell response.
Type de document :
Article dans une revue
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (6), pp.1629-38. 〈10.1002/eji.201041119〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00604898
Contributeur : Georges Guellaen <>
Soumis le : jeudi 30 juin 2011 - 09:01:23
Dernière modification le : jeudi 11 janvier 2018 - 06:23:10
Document(s) archivé(s) le : lundi 12 novembre 2012 - 09:50:56

Fichiers

Figures-eji-HAL.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Fanette Lasoudris, Céline Cousin, Armelle Prevost-Blondel, Nadine Martin-Garcia, Issam Abd-Alsamad, et al.. IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo.. European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (6), pp.1629-38. 〈10.1002/eji.201041119〉. 〈inserm-00604898〉

Partager

Métriques

Consultations de la notice

278

Téléchargements de fichiers

1483