M. Shoyab, V. L. Mcdonald, J. G. Bradley, and G. J. Todaro, Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol, p.12

H. Kimura, W. H. Fischer, and D. Schubert, Structure, expression and function of a schwannoma-derived growth factor, Nature, vol.348, issue.6298, pp.257-260, 1990.
DOI : 10.1038/348257a0

C. L. Brown, K. S. Meise, G. D. Plowman, R. J. Coffey, and P. J. Dempsey, Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor. RELEASE OF A PREDOMINANT N-GLYCOSYLATED 43-kDa SOLUBLE FORM, Journal of Biological Chemistry, vol.273, issue.27, pp.273-17258, 1998.
DOI : 10.1074/jbc.273.27.17258

M. J. Duffy, E. Mckiernan, N. O-'donovan, and P. M. Mcgowan, Role of ADAMs in Cancer Formation and Progression, Clinical Cancer Research, vol.15, issue.4, pp.1140-1144, 2009.
DOI : 10.1158/1078-0432.CCR-08-1585

N. C. Luetteke, T. H. Qiu, S. E. Fenton, K. L. Troyer, R. F. Riedel et al., Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development, Development, vol.126, pp.2739-2750, 1999.

M. Shoyab, G. D. Plowman, V. L. Mcdonald, J. G. Bradley, and G. J. Todaro, Structure and function of human amphiregulin: a member of the epidermal growth factor family, Science, vol.243, issue.4894, pp.1074-1076, 1989.
DOI : 10.1126/science.2466334

Y. Yarden and M. X. Sliwkowski, Untangling the ErbB signalling network, Nature Reviews Molecular Cell Biology, vol.2, issue.2, pp.127-137, 2001.
DOI : 10.1038/35052073

A. Citri and Y. Yarden, EGF???ERBB signalling: towards the systems level, Nature Reviews Molecular Cell Biology, vol.96, issue.7, pp.505-516, 2006.
DOI : 10.1038/nrm1962

M. A. Olayioye, R. M. Neve, H. A. Lane, and N. E. Hynes, NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer, The EMBO Journal, vol.19, issue.13, pp.3159-3167, 2000.
DOI : 10.1093/emboj/19.13.3159

T. Holbro, G. Civenni, and N. E. Hynes, The ErbB receptors and their role in cancer progression, Experimental Cell Research, vol.284, issue.1, pp.99-110, 2003.
DOI : 10.1016/S0014-4827(02)00099-X

R. R. Beerli and N. E. Hynes, Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities, J. Biol. Chem, pp.271-6071, 1996.

J. A. Barnard, R. Graves-deal, M. R. Pittelkow, R. Dubois, P. Cook et al., Auto-and cross-induction within the mammalian epidermal growth factor-related peptide family, J. Biol. Chem, pp.269-22817, 1994.

N. Normanno, A. De-luca, C. Bianco, L. Strizzi, M. Mancino et al., Epidermal growth factor receptor (EGFR) signaling in cancer, Gene, vol.366, issue.1, pp.2-16, 2006.
DOI : 10.1016/j.gene.2005.10.018

K. E. Longva, F. D. Blystad, E. Stang, A. M. Larsen, L. E. Johannessen et al., Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies, The Journal of Cell Biology, vol.112, issue.5, pp.843-854, 2002.
DOI : 10.1074/jbc.274.44.31707

K. A. Stern, T. L. Place, and N. L. , EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate, Biochemical Journal, vol.410, issue.3, pp.410-585, 2008.
DOI : 10.1042/BJ20071505

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507514

N. E. Willmarth, A. Baillo, M. L. Dziubinski, K. Wilson, D. J. Riese et al., Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop, Cellular Signalling, vol.21, issue.2, pp.212-219, 2009.
DOI : 10.1016/j.cellsig.2008.10.003

A. B. Singh and R. C. Harris, Autocrine, paracrine and juxtacrine signaling by EGFR ligands, Cellular Signalling, vol.17, issue.10, pp.1183-1193, 2005.
DOI : 10.1016/j.cellsig.2005.03.026

M. R. Schneider and E. Wolf, The epidermal growth factor receptor ligands at a glance, Journal of Cellular Physiology, vol.282, issue.3, pp.460-466, 2009.
DOI : 10.1002/jcp.21635

S. Li, G. D. Plowman, S. D. Buckley, and G. D. Shipley, Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells, Journal of Cellular Physiology, vol.48, issue.1, pp.153-103, 1992.
DOI : 10.1002/jcp.1041530114

M. D. Sternlicht, S. W. Sunnarborg, H. Kouros-mehr, Y. Yu, D. C. Lee et al., Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin, Development, vol.132, issue.17, pp.3923-3933, 2005.
DOI : 10.1242/dev.01966

N. E. Willmarth and S. P. Ethier, Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells, Journal of Biological Chemistry, vol.281, issue.49, pp.281-37728, 2006.
DOI : 10.1074/jbc.M606532200

A. A. Brandes, E. Franceschi, A. Tosoni, M. E. Hegi, and R. Stupp, Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments, Clinical Cancer Research, vol.14, issue.4, pp.957-960, 2008.
DOI : 10.1158/1078-0432.CCR-07-1810

O. Inatomi, A. Andoh, Y. Yagi, S. Bamba, T. Tsujikawa et al., Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts, International Journal of Molecular Medicine, vol.18, pp.497-503, 2006.
DOI : 10.3892/ijmm.18.3.497

C. Berasain, E. R. Garcia-trevijano, J. Castillo, E. Erroba, D. C. Lee et al., Amphiregulin: An early trigger of liver regeneration in mice, Gastroenterology, vol.128, issue.2, pp.424-432, 2005.
DOI : 10.1053/j.gastro.2004.11.006

A. Gschwind, S. Hart, O. M. Fischer, and A. Ullrich, TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells, The EMBO Journal, vol.22, issue.10, pp.2411-2421, 2003.
DOI : 10.1093/emboj/cdg231

G. D. Plowman, J. M. Green, V. L. Mcdonald, M. G. Neubauer, C. M. Disteche et al., The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity., Molecular and Cellular Biology, vol.10, issue.5, pp.10-1969, 1990.
DOI : 10.1128/MCB.10.5.1969

C. Berasain, E. R. Garcia-trevijano, J. Castillo, E. Erroba, M. Santamaria et al., Novel Role for Amphiregulin in Protection from Liver Injury, Journal of Biological Chemistry, vol.280, issue.19, pp.280-19012, 2005.
DOI : 10.1074/jbc.M413344200

L. Ciarloni, S. Mallepell, and C. Brisken, Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development, Proc. Natl

E. C. Tsark, E. D. Adamson, G. E. Withers, I. , and L. M. Wiley, Expression and function of amphiregulin during murine preimplantation development, Mol. Reprod. Dev, pp.47-271, 1997.

A. Kariagina, J. Xie, J. R. Leipprandt, and S. Z. Haslam, Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers, Hormones and Cancer, vol.150, issue.Suppl 1, pp.229-244, 2010.
DOI : 10.1007/s12672-010-0048-0

S. Lee, D. Medina, A. Tsimelzon, S. K. Mohsin, S. Mao et al., Alterations of Gene Expression in the Development of Early Hyperplastic Precursors of Breast Cancer, The American Journal of Pathology, vol.171, issue.1, pp.171-252, 2007.
DOI : 10.2353/ajpath.2007.061010

K. Ejskjaer, B. S. Sorensen, S. S. Poulsen, O. Mogensen, A. Forman et al., Expression of the epidermal growth factor system in human endometrium during the menstrual cycle, Molecular Human Reproduction, vol.11, issue.8, pp.11-543, 2005.
DOI : 10.1093/molehr/gah207

J. R. Sherwin, T. C. Freeman, R. J. Stephens, S. Kimber, A. G. Smith et al., Identification of Genes Regulated by Leukemia-Inhibitory Factor in the Mouse Uterus at the Time of Implantation, Molecular Endocrinology, vol.18, issue.9, pp.2185-2195, 2004.
DOI : 10.1210/me.2004-0110

H. Song, H. Lim, S. K. Das, B. C. Paria, and S. K. Dey, Dysregulation of EGF Family of Growth Factors and COX-2 in the Uterus during the Preattachment and Attachment Reactions of the Blastocyst with the Luminal Epithelium Correlates with Implantation Failure in LIF- Deficient Mice, Molecular Endocrinology, vol.14, issue.8, pp.14-1147, 2000.
DOI : 10.1210/mend.14.8.0498

S. K. Das, I. Chakraborty, B. C. Paria, X. N. Wang, G. Plowman et al., Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus, Mol. Endocrinol, vol.9, pp.691-705, 1995.

D. S. Lee, Y. Ueta, and H. Suzuki, Expression of Amphiregulin During the Pre- and Post-implantation Period in the Mouse Reproductive Tract, Journal of Reproduction and Development, vol.52, issue.6, pp.52-781, 2006.
DOI : 10.1262/jrd.18034

J. Reese, N. Binart, N. Brown, W. G. Ma, B. C. Paria et al., Implantation and Decidualization Defects in Prolactin Receptor (PRLR)-Deficient Mice Are Mediated by Ovarian But Not Uterine PRLR, Endocrinology, vol.141, issue.5, pp.1872-1881, 2000.
DOI : 10.1210/en.141.5.1872

J. Y. Park, Y. Q. Su, M. Ariga, E. Law, S. L. Jin et al., EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle, Science, vol.303, issue.5658, pp.682-684, 2004.
DOI : 10.1126/science.1092463

N. Torring, B. S. Sorensen, S. T. Bosch, H. Klocker, and E. Nexo, Amphiregulin is expressed in primary cultures of prostate myofibroblasts, fibroblasts, epithelial cells, and in prostate tissue, Prostate Cancer and Prostatic Diseases, vol.1, issue.5, pp.262-267, 1998.
DOI : 10.1038/sj.pcan.4500250

S. B. Lee, K. Huang, R. Palmer, V. B. Truong, D. Herzlinger et al., The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin, Cell, vol.98, issue.5, pp.663-673, 1999.
DOI : 10.1016/S0092-8674(00)80053-7

H. Sakurai, T. Tsukamoto, C. A. Kjelsberg, L. G. Cantley, and S. K. Nigam, EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney, Am. J. Physiol, pp.273-463, 1997.

L. Schuger, G. R. Johnson, K. Gilbride, G. D. Plowman, and R. Mandel, Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation, Development, vol.122, pp.1759-1767, 1996.

C. Berasain, J. Castillo, M. J. Perugorria, J. Prieto, and M. A. Avila, Amphiregulin: A new growth factor in hepatocarcinogenesis, Cancer Letters, vol.254, issue.1, pp.30-41, 2007.
DOI : 10.1016/j.canlet.2007.01.015

K. Shiraishi and H. Matsuyama, Local Expression of Epidermal Growth Factor-Like Growth Factors in Human Testis and Its Role in Spermatogenesis, Journal of Andrology, vol.33, issue.1, 2011.
DOI : 10.2164/jandrol.110.011981

L. Qin, J. Tamasi, L. Raggatt, X. Li, J. H. Feyen et al., Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation, Journal of Biological Chemistry, vol.280, issue.5, pp.280-3974, 2005.
DOI : 10.1074/jbc.M409807200

L. Qin and N. C. Partridge, Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response elementbinding protein signaling pathway, J. Cell. Biochem, pp.96-632, 2005.

T. Tondreau, M. Dejeneffe, N. Meuleman, B. Stamatopoulos, A. Delforge et al., Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells, BMC Genomics, vol.9, issue.1, 2008.
DOI : 10.1186/1471-2164-9-166

A. Falk and J. Frisen, Amphiregulin is a mitogen for adult neural stem cells, Journal of Neuroscience Research, vol.2, issue.6, pp.757-762, 2002.
DOI : 10.1002/jnr.10410

A. Nilsson, K. Moller, L. Dahlin, G. Lundborg, and M. Kanje, Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration, Molecular Brain Research, vol.136, issue.1-2, pp.65-74, 2005.
DOI : 10.1016/j.molbrainres.2005.01.008

L. Rittie, J. Varani, S. Kang, J. J. Voorhees, and G. J. Fisher, Retinoid-Induced Epidermal Hyperplasia Is Mediated by Epidermal Growth Factor Receptor Activation Via Specific Induction of its Ligands Heparin-Binding EGF and Amphiregulin in Human Skin In Vivo, Journal of Investigative Dermatology, vol.126, issue.4, pp.126-732, 2006.
DOI : 10.1038/sj.jid.5700202

N. Normanno, F. Ciardiello, R. Brandt, and D. S. Salomon, Epidermal growth factorrelated peptides in the pathogenesis of human breast cancer, Breast Cancer Res. Treat, pp.29-40, 1994.

. Avila, The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis, Hepatology, vol.48, pp.1251-1261, 2008.

G. D. Richardson, H. Bazzi, K. A. Fantauzzo, J. M. Waters, H. Crawford et al., KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin, Development, vol.136, issue.13, pp.2153-2164, 2009.
DOI : 10.1242/dev.031427

P. W. Cook, P. A. Mattox, W. W. Keeble, M. R. Pittelkow, G. D. Plowman et al., A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin., Molecular and Cellular Biology, vol.11, issue.5, pp.11-2547, 1991.
DOI : 10.1128/MCB.11.5.2547

E. Chung, P. W. Cook, C. A. Parkos, Y. K. Park, M. R. Pittelkow et al., Amphiregulin Causes Functional Downregulation of Adherens Junctions in Psoriasis, Journal of Investigative Dermatology, vol.124, issue.6, pp.1134-1140, 2005.
DOI : 10.1111/j.0022-202X.2005.23762.x

S. W. Stoll, J. L. Johnson, Y. Li, L. Rittie, and J. T. Elder, Amphiregulin Carboxy-Terminal Domain Is Required for Autocrine Keratinocyte Growth, Journal of Investigative Dermatology, vol.130, issue.8, pp.2031-2040
DOI : 10.1038/jid.2010.98

D. Hanahan and R. A. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011.
DOI : 10.1016/j.cell.2011.02.013

J. Mcbryan, J. Howlin, S. Napoletano, and F. Martin, Amphiregulin: Role in Mammary Gland Development and Breast Cancer, Journal of Mammary Gland Biology and Neoplasia, vol.11, issue.12, pp.159-169, 2008.
DOI : 10.1007/s10911-008-9075-7

N. Eckstein, K. Servan, L. Girard, D. Cai, G. Von-jonquieres et al., Epidermal Growth Factor Receptor Pathway Analysis Identifies Amphiregulin as a Key Factor for Cisplatin Resistance of Human Breast Cancer Cells, Journal of Biological Chemistry, vol.283, issue.2, pp.739-750, 2008.
DOI : 10.1074/jbc.M706287200

C. L. Addison, K. Ding, H. Zhao, A. Le-maitre, G. D. Goss et al., Plasma transforming growth factor {alpha} and amphiregulin protein levels in NCIC Clinical Trials Group BR, J. Clin. Oncol, vol.21, 2010.

N. Ishikawa, Y. Daigo, A. Takano, M. Taniwaki, T. Kato et al., Increases of Amphiregulin and Transforming Growth Factor-?? in Serum as Predictors of Poor Response to Gefitinib among Patients with Advanced Non-Small Cell Lung Cancers, Cancer Research, vol.65, issue.20, pp.9176-9184, 2005.
DOI : 10.1158/0008-5472.CAN-05-1556

D. Hanahan and R. A. Weinberg, The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000.
DOI : 10.1016/S0092-8674(00)81683-9

N. Normanno, M. P. Selvam, C. F. Qi, T. Saeki, G. Johnson et al., Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells., Proceedings of the National Academy of Sciences, vol.91, issue.7, pp.91-2790, 1994.
DOI : 10.1073/pnas.91.7.2790

I. M. Berquin, M. L. Dziubinski, G. P. Nolan, and S. P. Ethier, A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin, Oncogene, vol.20, issue.30, pp.4019-4028, 2001.
DOI : 10.1038/sj.onc.1204537

J. Castillo, E. Erroba, M. J. Perugorria, M. Santamaria, D. C. Lee et al., Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells, Cancer Res, pp.66-6129, 2006.

A. Hurbin, L. Dubrez, J. L. Coll, and M. C. Favrot, Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines, J. Biol. Chem, pp.277-49127, 2002.

G. R. Johnson, T. Saeki, A. W. Gordon, M. Shoyab, D. S. Salomon et al., Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon, The Journal of Cell Biology, vol.118, issue.3, pp.741-751, 1992.
DOI : 10.1083/jcb.118.3.741

I. Zvibel, S. Brill, Z. Halpern, and M. Papa, Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability, J. Cell. Biochem, pp.76-332, 1999.

M. Kato, T. Inazu, Y. Kawai, K. Masamura, M. Yoshida et al., Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5, Biochemical and Biophysical Research Communications, vol.301, issue.4, pp.301-1109, 2003.
DOI : 10.1016/S0006-291X(03)00093-7

L. Ma, C. Gauville, Y. Berthois, G. Millot, G. R. Johnson et al., Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line, Oncogene, vol.18, issue.47, pp.6513-6520, 1999.
DOI : 10.1038/sj.onc.1203042

H. Funatomi, J. Itakura, T. Ishiwata, I. Pastan, S. A. Thompson et al., Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy, International Journal of Cancer, vol.7, issue.3, pp.512-517, 1997.
DOI : 10.1002/(SICI)1097-0215(19970729)72:3<512::AID-IJC21>3.0.CO;2-C

T. Saeki, K. Stromberg, C. F. Qi, W. J. Gullick, E. Tahara et al., Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors, Cancer Res, vol.52, pp.3467-3473, 1992.

S. Lejeune, R. Leek, E. Horak, G. Plowman, M. Greenall et al., Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer, Cancer Res, vol.53, pp.3597-3602, 1993.

L. Panico, A. D. Antonio, G. Salvatore, E. Mezza, G. Tortora et al., Differential immunohistochemical detection of transforming growth factor ??, amphiregulin and CRIPTO in human normal and malignant breast tissues, International Journal of Cancer, vol.420, issue.1, pp.51-56, 1996.
DOI : 10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0

J. Dong, L. K. Opresko, P. J. Dempsey, D. A. Lauffenburger, R. J. Coffey et al., Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor, Proceedings of the National Academy of Sciences, vol.96, issue.11, pp.96-6235, 1999.
DOI : 10.1073/pnas.96.11.6235

S. W. Stoll, J. L. Johnson, Y. Li, L. Rittie, and J. T. Elder, Amphiregulin Carboxy-Terminal Domain Is Required for Autocrine Keratinocyte Growth, Journal of Investigative Dermatology, vol.130, issue.8, pp.130-2031, 2010.
DOI : 10.1038/jid.2010.98

C. Bavik, I. Coleman, J. P. Dean, B. Knudsen, S. Plymate et al., The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms, Cancer Research, vol.66, issue.2, pp.794-802, 2006.
DOI : 10.1158/0008-5472.CAN-05-1716

Y. Lemos-gonzalez, F. J. Rodriguez-berrocal, O. J. Cordero, C. Gomez, and M. , Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma, British Journal of Cancer, vol.10, issue.10, pp.1569-1578, 2007.
DOI : 10.1002/(SICI)1097-0142(19960315)77:6<1056::AID-CNCR8>3.0.CO;2-F

A. Murthy, V. Defamie, D. S. Smookler, M. A. Di-grappa, K. Horiuchi et al., Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice, Journal of Clinical Investigation, vol.120, issue.8, pp.2731-2744, 2010.
DOI : 10.1172/JCI42686DS1

. Favrot, Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax-and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells, J. Biol. Chem, pp.280-19757, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00340599

M. Lorente, A. Carracedo, S. Torres, F. Natali, A. Egia et al., Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis, Glia, vol.14, issue.13, pp.1374-1385, 2009.
DOI : 10.1002/glia.20856

L. Hayflick, Mortality and immortality at the cellular level. A review, Biochemistry (Mosc), vol.62, pp.1180-1190, 1997.

M. Matsui, J. Miyasaka, K. Hamada, Y. Ogawa, M. Hiramoto et al., Influence of aging and cell senescence on telomerase activity in keratinocytes, Journal of Dermatological Science, vol.22, issue.2, pp.22-80, 2000.
DOI : 10.1016/S0923-1811(99)00049-3

A. S. Chung, J. Lee, and N. Ferrara, Targeting the tumour vasculature: insights from physiological angiogenesis, Nature Reviews Cancer, vol.15, issue.7, pp.505-514, 2010.
DOI : 10.1038/nrc2868

C. W. Pugh and P. J. Ratcliffe, Regulation of angiogenesis by hypoxia: role of the HIF system, Nature Medicine, vol.9, issue.6, pp.677-684, 2003.
DOI : 10.1038/nm0603-677

J. Pouyssegur, F. Dayan, and N. M. Mazure, Hypoxia signalling in cancer and approaches to enforce tumour regression, Nature, vol.9, issue.7092, pp.437-443, 2006.
DOI : 10.1038/nature04871

URL : https://hal.archives-ouvertes.fr/hal-00321054

G. L. Semenza, Targeting HIF-1 for cancer therapy, Nature Reviews Cancer, vol.3, issue.10, pp.721-732, 2003.
DOI : 10.1038/nrc1187

N. Ferrara, VEGF and the quest for tumour angiogenesis factors, Nature Reviews Cancer, vol.120, issue.10, pp.795-803, 2002.
DOI : 10.1038/nrc909

M. R. Bordoli, D. P. Stiehl, L. Borsig, G. Kristiansen, S. Hausladen et al., Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis, Oncogene, vol.59, issue.5, 2010.
DOI : 10.1016/j.ccr.2009.09.029

D. A. Chan, T. L. Kawahara, P. D. Sutphin, H. Y. Chang, J. T. Chi et al., Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrowderived cell recruitment, Cancer Cell, pp.15-527, 2009.

D. A. Chan and A. J. Giaccia, PHD2 in tumour angiogenesis, British Journal of Cancer, vol.59, issue.1, pp.1-5, 2010.
DOI : 10.1073/PNAS.181341498

M. Mazzone, D. Dettori, R. Leite-de-oliveira, S. Loges, T. Schmidt et al., Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization, Cell, vol.136, issue.5, pp.839-851, 2009.
DOI : 10.1016/j.cell.2009.01.020

C. Giusti, S. Desruisseau, L. Ma, F. Calvo, P. M. Martin et al., Transforming growth factor ?-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells, International Journal of Cancer, vol.13, issue.6, pp.769-778, 2003.
DOI : 10.1002/ijc.11158

URL : https://hal.archives-ouvertes.fr/inserm-00156319

G. T. Wagenaar, S. A. Ter-horst, M. A. Van-gastelen, L. M. Leijser, T. Mauad et al., Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress, Free Radic, Biol. Med, pp.36-782, 2004.

S. M. O-'reilly, M. O. Leonard, N. Kieran, K. M. Comerford, E. Cummins et al., Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner, Am. J. Physiol. Cell Physiol, pp.290-592, 2006.

T. H. Hung, S. F. Chen, C. C. Hsieh, J. J. Hsu, M. J. Li et al., Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation, Reprod. Sci, pp.15-195, 2008.

K. Deacon and A. J. Knox, Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways: ROLE OF A PHOSPHOLIPASE A2(cPLA2)/CYCLOOXYGENASE-2 (COX-2)/PROSTACYCLIN RECEPTOR-DEPENDENT AUTOCRINE LOOP, Journal of Biological Chemistry, vol.285, issue.34, pp.285-25913, 2010.
DOI : 10.1074/jbc.M110.139485

S. Donahoe and . Maheswaran, HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis, Proc. Natl. Acad. Sci. U.S.A, vol.107, pp.1100-1105, 2010.

J. Shao, S. B. Lee, H. Guo, B. M. Evers, and H. Sheng, Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin, Cancer Res, vol.63, pp.5218-5223, 2003.

N. E. Willmarth and S. P. Ethier, Amphiregulin as a Novel Target for Breast Cancer Therapy, Journal of Mammary Gland Biology and Neoplasia, vol.406, issue.6797, pp.171-179, 2008.
DOI : 10.1007/s10911-008-9081-9

M. Silvy, C. Giusti, P. M. Martin, and Y. Berthois, Differential regulation of cell proliferation and protease secretion by epidermal growth factor and amphiregulin in tumoral versus normal breast epithelial cells, British Journal of Cancer, vol.84, issue.7, pp.936-945, 2001.
DOI : 10.1054/bjoc.2000.1678

F. Ciardiello, N. Kim, T. Saeki, R. Dono, M. G. Persico et al., Differential expression of epidermal growth factor-related proteins in human colorectal tumors., Proceedings of the National Academy of Sciences, vol.88, issue.17, pp.7792-7796, 1991.
DOI : 10.1073/pnas.88.17.7792

V. Picihard, Y. Berthois, M. Roccabianca, C. Prevot, M. Sarrazin et al., Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion, Anticancer Res, vol.26, pp.2769-2783, 2006.

O. C. , H. Modjtahedi, P. Rhys-evans, W. J. Court, G. M. Box et al., Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells, Cancer Res, vol.60, pp.1121-1128, 2000.

S. Menashi, M. Serova, L. Ma, S. Vignot, S. Mourah et al., Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells, Cancer Res, vol.63, pp.7575-7580, 2003.

S. B. Kondapaka, R. Fridman, and K. B. Reddy, Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells, International Journal of Cancer, vol.264, issue.6, pp.722-726, 1997.
DOI : 10.1002/(SICI)1097-0215(19970317)70:6<722::AID-IJC15>3.0.CO;2-B

Z. Liu and J. Klominek, Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors, Thorax, vol.58, issue.3, pp.198-203, 2003.
DOI : 10.1136/thorax.58.3.198

M. A. Huber, N. Kraut, and H. Beug, Molecular requirements for epithelial???mesenchymal transition during tumor progression, Current Opinion in Cell Biology, vol.17, issue.5, pp.548-558, 2005.
DOI : 10.1016/j.ceb.2005.08.001

A. Rohrbeck and J. Borlak, Cancer Genomics Identifies Regulatory Gene Networks Associated with the Transition from Dysplasia to Advanced Lung Adenocarcinomas Induced by c-Raf-1, PLoS ONE, vol.98, issue.4, p.7315, 2009.
DOI : 10.1371/journal.pone.0007315.s009

Q. Q. Li, Z. Q. Chen, X. X. Cao, J. D. Xu, J. W. Xu et al., Involvement of NF-kappaB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial?mesenchymal transition of breast cancer cells, Cell Death Differ, 2010.

J. Zhang, J. Y. Ji, M. Yu, M. Overholtzer, G. A. Smolen et al., YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway, Nature Cell Biology, vol.50, issue.12, pp.1444-1450, 2009.
DOI : 10.1126/science.277.5329.1103

R. M. Adam, S. G. Chamberlin, and D. E. Davies, Induction of Anchorage-Independent Growth by Amphiregulin, Growth Factors, vol.14, issue.2, pp.193-203, 1996.
DOI : 10.3109/08977199609003221

N. Normanno, M. P. Selvam, C. Bianco, V. Damiano, E. De-angelis et al., Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line, International Journal of Cancer, vol.47, issue.6, pp.762-766, 1995.
DOI : 10.1002/ijc.2910620619

N. Tarbe, S. Losch, H. Burtscher, M. Jarsch, and U. H. Weidle, Identification of rat pancreatic carcinoma genes associated with lymphogenous metastasis, Anticancer Res, vol.22, pp.2015-2027, 2002.

T. Watanabe, T. Kobunai, Y. Yamamoto, T. Kanazawa, T. Konishi et al., Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes, European Journal of Cancer, vol.46, issue.11, pp.2119-2126, 2010.
DOI : 10.1016/j.ejca.2010.04.019

X. D. Li, S. Y. Miao, G. L. Wang, L. Yang, Y. Q. Shu et al., Amphiregulin and Epiregulin Expression in Colorectal Carcinoma and the Correlation with Clinicopathological Characteristics, Onkologie, vol.33, issue.7, pp.353-358, 2010.
DOI : 10.1159/000315380

M. Sun, C. Behrens, L. Feng, N. Ozburn, X. Tang et al., HER Family Receptor Abnormalities in Lung Cancer Brain Metastases and Corresponding Primary Tumors, Clinical Cancer Research, vol.15, issue.15, pp.4829-4837, 2009.
DOI : 10.1158/1078-0432.CCR-08-2921

M. Yamada, Y. Ichikawa, S. Yamagishi, N. Momiyama, M. Ota et al., Amphiregulin Is a Promising Prognostic Marker for Liver Metastases of Colorectal Cancer, Clinical Cancer Research, vol.14, issue.8, pp.2351-2356, 2008.
DOI : 10.1158/1078-0432.CCR-07-4499

K. Ogawa, T. Utsunomiya, K. Mimori, F. Tanaka, N. Haraguchi et al., Differential gene expression profiles of radioresistant pancreatic cancer cell lines established by fractionated irradiation, International Journal of Oncology, pp.28-705, 2006.
DOI : 10.3892/ijo.28.3.705

M. Toulany, M. Baumann, and H. P. Rodemann, Stimulated PI3K-AKT Signaling Mediated through Ligand or Radiation-Induced EGFR Depends Indirectly, but not Directly, on Constitutive K-Ras Activity, Molecular Cancer Research, vol.5, issue.8, pp.863-872, 2007.
DOI : 10.1158/1541-7786.MCR-06-0297

M. Toulany, K. Dittmann, M. Kruger, M. Baumann, and H. P. Rodemann, Radioresistance of K-Ras mutated human tumor cells is mediated through EGFRdependent activation of PI3K-AKT pathway, Radiother. Oncol, pp.76-143, 2005.

C. J. Chang, P. H. Yin, D. M. Yang, C. H. Wang, W. Y. Hung et al., Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells, Cellular and Molecular Life Sciences, vol.66, issue.10, pp.1755-1765, 2009.
DOI : 10.1007/s00018-009-8767-5

X. Wang, S. Masri, S. Phung, and S. Chen, The Role of Amphiregulin in Exemestane-Resistant Breast Cancer Cells: Evidence of an Autocrine Loop, Cancer Research, vol.68, issue.7, pp.2259-2265, 2008.
DOI : 10.1158/0008-5472.CAN-07-5544

G. Fontanini, M. De-laurentiis, S. Vignati, S. Chine, M. Lucchi et al., Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I?IIIA non-smallcell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival, Clin. Cancer Res, vol.4, pp.241-249, 1998.

D. W. Visscher, F. H. Sarkar, T. C. Kasunic, and K. B. Reddy, Clinicopathologic analysis of amphiregulin and heregulin immunostaining in breast neoplasia, Breast Cancer Research and Treatment, vol.10, issue.1, pp.45-75, 1997.
DOI : 10.1023/A:1005845512804

D. G. Bostwick, J. Qian, and N. J. Maihle, Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: A study of 93 cases, The Prostate, vol.82, issue.2, pp.164-168, 2004.
DOI : 10.1002/pros.10322

M. Ebert, M. Yokoyama, M. S. Kobrin, H. Friess, M. E. Lopez et al., Induction and expression of amphiregulin in human pancreatic cancer, Cancer Res, pp.54-3959, 1994.

T. Nishimura, A. Andoh, O. Inatomi, M. Shioya, Y. Yagi et al., Amphiregulin and epiregulin expression in neoplastic and inflammatory lesions in the colon, Oncology Reports, vol.19, pp.105-110, 2008.
DOI : 10.3892/or.19.1.105

V. B. Thogersen, B. S. Sorensen, S. S. Poulsen, T. F. Orntoft, H. Wolf et al., A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients, Cancer Res, pp.61-6227, 2001.

J. Kleeff, H. Friess, P. O. Berberat, M. E. Martignoni, K. Z-'graggen et al., Pancreatic Cancer - New Aspects of Molecular Biology Research, Swiss Surgery, vol.6, issue.5, pp.231-234, 2000.
DOI : 10.1024/1023-9332.6.5.231

A. D. Antonio, S. Losito, S. Pignata, M. Grassi, F. Perrone et al., Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas, Int. J. Oncol, vol.21, pp.941-948, 2002.

D. S. Salomon, R. Brandt, F. Ciardiello, and N. Normanno, Epidermal growth factor-related peptides and their receptors in human malignancies, Critical Reviews in Oncology/Hematology, vol.19, issue.3, pp.183-232, 1995.
DOI : 10.1016/1040-8428(94)00144-I

N. E. Hynes and H. A. Lane, ERBB receptors and cancer: the complexity of targeted inhibitors, Nature Reviews Cancer, vol.7, issue.5, pp.341-354, 2005.
DOI : 10.1021/jm00130a020

I. Burris, E. A. Poplin, M. Hidalgo, J. Baselga, E. A. Clark et al., Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab, J. Clin. Oncol, pp.25-3230, 2007.

B. Jacobs, W. De-roock, H. Piessevaux, R. Van-oirbeek, B. Biesmans et al., Amphiregulin and Epiregulin mRNA Expression in Primary Tumors Predicts Outcome in Metastatic Colorectal Cancer Treated With Cetuximab, Journal of Clinical Oncology, vol.27, issue.30, pp.27-5068, 2009.
DOI : 10.1200/JCO.2008.21.3744

C. Oliveras-ferraros, A. M. Vall-llovera, D. C. Salip, A. Vazquez-martin, S. Cufi et al., Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells, Investigational New Drugs, vol.103, issue.2, 2010.
DOI : 10.1007/s10637-010-9612-2

C. Oliveras-ferraros, A. Vazquez-martin, S. Cufi, B. Queralt, L. Baez et al., The stem cell property epithelial-to-mesenchymal transition (EMT) is a core transcriptional network for predicting cetuximab (Erbitux) efficacy in KRAS wild-type tumor cells, J Cell Biochem, 2010.

J. B. Baker, D. Dutta, D. Watson, T. Maddala, B. M. Munneke et al., Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer, British Journal of Cancer, vol.9, issue.3, pp.488-495, 2011.
DOI : 10.1126/science.1073096

R. Krumbach, J. Schuler, M. Hofmann, T. Giesemann, H. H. Fiebig et al., Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance, European Journal of Cancer, vol.47, issue.8, 2011.
DOI : 10.1016/j.ejca.2010.12.019

S. J. Rogers, C. Box, P. Chambers, Y. Barbachano, C. M. Nutting et al., Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck, The Journal of Pathology, vol.271, issue.1, pp.218-122, 2009.
DOI : 10.1002/path.2515

K. Yonesaka, K. Zejnullahu, N. Lindeman, A. J. Homes, D. M. Jackman et al., Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers, Clin, Cancer Res, vol.14, pp.6963-6973, 2008.

M. H. Chang, H. K. Ahn, J. Lee, C. K. Jung, Y. L. Choi et al., Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors, Cancer, vol.18, issue.1, pp.143-151, 2011.
DOI : 10.1002/cncr.25560

M. A. Vollebergh, I. Kappers, H. M. Klomp, J. C. Buning-kager, C. M. Korse et al., Ligands of Epidermal Growth Factor Receptor and the Insulin-Like Growth Factor Family as Serum Biomarkers for Response to Epidermal Growth Factor Receptor Inhibitors in Patients with Advanced Non-small Cell Lung Cancer, Journal of Thoracic Oncology, vol.5, issue.12, pp.1939-1948, 2010.
DOI : 10.1097/JTO.0b013e3181f77a39

A. B. Motoyama, N. E. Hynes, and H. A. Lane, The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides, Cancer Res, vol.62, pp.3151-3158, 2002.

C. Oliveras-ferraros, A. Vazquez-martin, B. Martin-castillo, M. C. Perez-martinez, S. Cufi et al., Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin), Int. J. Oncol, vol.37, pp.669-678, 2010.

L. Ferrer-soler, A. Vazquez-martin, J. Brunet, J. A. Menendez, R. De-llorens et al., An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa???)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review), International Journal of Molecular Medicine, vol.20, pp.3-10, 2007.
DOI : 10.3892/ijmm.20.1.3

C. Li, M. Iida, E. F. Dunn, A. J. Ghia, and D. L. Wheeler, Nuclear EGFR contributes to acquired resistance to cetuximab, Oncogene, vol.8, issue.43, pp.3801-3813, 2009.
DOI : 10.1038/35052073

S. Kakiuchi, Y. Daigo, N. Ishikawa, C. Furukawa, T. Tsunoda et al., Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839), Human Molecular Genetics, vol.13, issue.24, pp.13-3029, 2004.
DOI : 10.1093/hmg/ddh331

F. R. Hirsch and S. Witta, Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer, Current Opinion in Oncology, vol.17, issue.2, pp.118-122, 2005.
DOI : 10.1097/01.cco.0000155059.39733.9d

B. Busser, L. Sancey, V. Josserand, C. Niang, M. C. Favrot et al., Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers, Molecular Therapy, vol.18, issue.3, pp.528-535, 2010.
DOI : 10.1038/mt.2009.226

URL : https://hal.archives-ouvertes.fr/inserm-00425468

B. Busser, L. Sancey, V. Josserand, C. Niang, S. Khochbin et al., Amphiregulin Promotes Resistance to Gefitinib in NonSmall Cell Lung Cancer Cells by Regulating Ku70 Acetylation, Molecular Therapy, vol.18, issue.3, pp.536-543, 2010.
DOI : 10.1038/mt.2009.227

URL : https://hal.archives-ouvertes.fr/inserm-00425467

F. Yotsumoto, H. Yagi, S. O. Suzuki, E. Oki, H. Tsujioka et al., Validation of HB-EGF and amphiregulin as targets for human cancer therapy, Biochemical and Biophysical Research Communications, vol.365, issue.3, pp.365-555, 2008.
DOI : 10.1016/j.bbrc.2007.11.015

M. Piepkorn, C. Lo, and G. Plowman, Amphiregulin-dependent proliferation of cultured human keratinocytes: Autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans, Journal of Cellular Physiology, vol.64, issue.1, pp.159-114, 1994.
DOI : 10.1002/jcp.1041590115

P. A. Kenny and M. J. Bissell, Targeting TACE-dependent EGFR ligand shedding in breast cancer, Journal of Clinical Investigation, vol.117, issue.2, pp.337-345, 2007.
DOI : 10.1172/JCI29518DS1

J. N. Kyula, S. Van-schaeybroeck, J. Doherty, C. S. Fenning, D. B. Longley et al., Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer, Clinical Cancer Research, vol.16, issue.13, pp.3378-3389, 2010.
DOI : 10.1158/1078-0432.CCR-10-0014

A. De-luca, M. P. Selvam, C. Sandomenico, S. Pepe, A. R. Bianco et al., Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells, International Journal of Cancer, vol.92, issue.2, pp.277-282, 1997.
DOI : 10.1002/(SICI)1097-0215(19971009)73:2<277::AID-IJC19>3.0.CO;2-C

F. Yotsumoto, T. Fukami, H. Yagi, A. Funakoshi, T. Yoshizato et al., Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer, Cancer Science, vol.19, issue.11, pp.2351-2360, 2010.
DOI : 10.1111/j.1349-7006.2010.01671.x

N. Puri and R. Salgia, Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer, Journal of Carcinogenesis, vol.7, issue.1, 2008.
DOI : 10.4103/1477-3163.44372

J. M. Ricono, M. Huang, L. A. Barnes, S. K. Lau, S. M. Weis et al., Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis, Cancer Res, pp.69-1383, 2009.
DOI : 10.1158/0008-5472.can-08-3612

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741736

S. M. Thomas, N. E. Bhola, Q. Zhang, S. C. Contrucci, A. L. Wentzel et al., Cross-talk between G Protein-Coupled Receptor and Epidermal Growth Factor Receptor Signaling Pathways Contributes to Growth and Invasion of Head and Neck Squamous Cell Carcinoma, Cancer Research, vol.66, issue.24, pp.11831-11839, 2006.
DOI : 10.1158/0008-5472.CAN-06-2876

A. G. Recchia, A. M. Musti, M. Lanzino, M. L. Panno, E. Turano et al., A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK-dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells, The International Journal of Biochemistry & Cell Biology, vol.41, issue.3, pp.41-603, 2009.
DOI : 10.1016/j.biocel.2008.07.004

Y. Saito, J. Haendeler, Y. Hojo, K. Yamamoto, and B. C. Berk, Receptor Heterodimerization: Essential Mechanism for Platelet-Derived Growth Factor-Induced Epidermal Growth Factor Receptor Transactivation, Molecular and Cellular Biology, vol.21, issue.19, pp.6387-6394, 2001.
DOI : 10.1128/MCB.21.19.6387-6394.2001

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC99786

F. Morgillo, J. K. Woo, E. S. Kim, W. K. Hong, and H. Y. Lee, Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib, Cancer Res, pp.66-10100, 2006.

N. Akutsu, Y. Bastien, R. Lin, S. Mader, and J. H. White, Amphiregulin Is a Vitamin D3 Target Gene in Squamous Cell and Breast Carcinoma, Biochemical and Biophysical Research Communications, vol.281, issue.4, pp.281-1051, 2001.
DOI : 10.1006/bbrc.2001.4466

C. D. Woodworth, E. Mcmullin, M. Iglesias, and G. D. Plowman, Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells., Proceedings of the National Academy of Sciences, vol.92, issue.7, pp.92-2840, 1995.
DOI : 10.1073/pnas.92.7.2840

K. L. Bennett, G. D. Plowman, S. D. Buckley, J. Skonier, and A. F. Purchio, Regulation of Amphiregulin mRNA by TGF-?? in the Human Lung Adenocarcinoma Cell Line A549, Growth Factors, vol.263, issue.3, pp.207-213, 1992.
DOI : 10.1146/annurev.cb.06.110190.003121

S. Tsutsui, Y. Shinomura, S. Higashiyama, Y. Higashimoto, Y. Miyazaki et al., Induction of heparin binding epidermal growth factorlike growth factor and amphiregulin mRNAs by gastrin in the rat stomach, Biochem. Biophys. Res. Commun, pp.235-520, 1997.

Q. Zhang, S. M. Thomas, V. W. Lui, S. Xi, J. M. Siegfried et al., Phosphorylation of TNF-?? converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation, Proceedings of the National Academy of Sciences, vol.103, issue.18, pp.6901-6906, 2006.
DOI : 10.1073/pnas.0509719103

J. Shao, G. G. Sheng, R. C. Mifflin, D. W. Powell, and H. Sheng, Roles of Myofibroblasts in Prostaglandin E2-Stimulated Intestinal Epithelial Proliferation and Angiogenesis, Cancer Research, vol.66, issue.2, pp.846-855, 2006.
DOI : 10.1158/0008-5472.CAN-05-2606

I. Sehgal, J. Bailey, K. Hitzemann, M. R. Pittelkow, and N. J. Maihle, Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells., Molecular Biology of the Cell, vol.5, issue.3, pp.339-347, 1994.
DOI : 10.1091/mbc.5.3.339

S. W. Curtis, J. Clark, P. Myers, and K. S. Korach, Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus, Proc. Natl. Acad. Sci. U.S.A, pp.96-3646, 1999.

A. Khatua, X. Wang, T. Ding, Q. Zhang, J. Reese et al., Indian Hedgehog, But Not Histidine Decarboxylase or Amphiregulin, Is a Progesterone-Regulated Uterine Gene in Hamsters, Endocrinology, vol.147, issue.9, pp.4079-4092, 2006.
DOI : 10.1210/en.2006-0231

J. I. Huh, T. H. Qiu, G. V. Chandramouli, R. Charles, M. Wiench et al., 2-Methoxyestradiol Induces Mammary Gland Differentiation through Amphiregulin-Epithelial Growth Factor Receptor-Mediated Signaling: Molecular Distinctions from the Mammary Gland of Pregnant Mice, Endocrinology, vol.148, issue.3, pp.1266-1277, 2007.
DOI : 10.1210/en.2006-0964

H. L. Lamarca, J. M. Rosen, I. Martinez-lacaci, M. Saceda, G. D. Plowman et al., Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines, Breast Cancer Res. Endocrinology, vol.9, issue.136, pp.3983-3992, 1995.

H. Negishi, C. Ikeda, Y. Nagai, A. Satoh, Y. Kumasako et al., Regulation of amphiregulin, EGFR-like factor expression by hCG in cultured human granulosa cells, Acta Obstetricia et Gynecologica Scandinavica, vol.86, issue.6, pp.86-706, 2007.
DOI : 10.1080/00016340701314959

C. C. Johansson, A. Yndestad, J. M. Enserink, A. H. Ree, P. Aukrust et al., The Epidermal Growth Factor-Like Growth Factor Amphiregulin Is Strongly Induced by the Adenosine 3???,5???-Monophosphate Pathway in Various Cell Types, Endocrinology, vol.145, issue.11, pp.5177-5184, 2004.
DOI : 10.1210/en.2004-0232

D. Ornskov, E. Nexo, and B. S. Sorensen, Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: Identification of a specific insulin-responsive promoter element, Biochemical and Biophysical Research Communications, vol.354, issue.4, pp.354-885, 2007.
DOI : 10.1016/j.bbrc.2007.01.047

D. A. Vardy, C. Kari, G. S. Lazarus, P. J. Jensen, A. Zilberstein et al., Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1, Journal of Cellular Physiology, vol.99, issue.2, pp.163-257, 1995.
DOI : 10.1002/jcp.1041630206

Y. Miyazaki, Y. Shinomura, S. Tsutsui, Y. Yasunaga, S. Zushi et al., Oxidative stress increases gene expression of heparinbinding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells, Biochem. Biophys. Res. Commun, pp.226-542, 1996.

K. Horiuchi, S. L. Gall, M. Schulte, T. Yamaguchi, K. Reiss et al., Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx, Molecular Biology of the Cell, vol.18, issue.1, pp.176-188, 2007.
DOI : 10.1091/mbc.E06-01-0014

S. Blanchet, K. Ramgolam, A. Baulig, F. Marano, and A. , Baeza-Squiban, Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells, Am. J. Respir. Cell Mol. Biol, pp.30-421, 2004.
DOI : 10.1165/rcmb.2003-0281rc

M. Rumelhard, K. Ramgolam, F. Auger, A. C. Dazy, S. Blanchet et al., Baeza- Squiban, Effects of PM2.5 components in the release of amphiregulin by human airway epithelial cells, Toxicol. Lett, pp.168-155, 2007.

S. S. Choi, M. A. Miller, and P. A. Harper, -tetrachlorodi- benzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter, Toxicol. Sci, vol.7, issue.8, pp.94-163, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00857436

B. Du, N. K. Altorki, L. Kopelovich, K. Subbaramaiah, and A. J. Dannenberg, Tobacco Smoke Stimulates the Transcription of Amphiregulin in Human Oral Epithelial Cells: Evidence of a Cyclic AMP-Responsive Element Binding Protein-Dependent Mechanism, Cancer Research, vol.65, issue.13, pp.65-5982, 2005.
DOI : 10.1158/0008-5472.CAN-05-0628

H. Lemjabbar, D. Li, M. Gallup, S. Sidhu, E. Drori et al., Tobacco smokeinduced lung cell proliferation mediated by tumor necrosis factor alphaconverting enzyme and amphiregulin, J. Biol. Chem, pp.278-26202, 2003.

M. Vecchi, L. A. Rudolph-owen, C. L. Brown, P. J. Dempsey, and G. Carpenter, Tyrosine Phosphorylation and Proteolysis: PERVANADATE-INDUCED, METALLOPROTEASE-DEPENDENT CLEAVAGE OF THE ErbB-4 RECEPTOR AND AMPHIREGULIN, Journal of Biological Chemistry, vol.273, issue.32, pp.273-20589, 1998.
DOI : 10.1074/jbc.273.32.20589

N. Normanno, N. Kim, D. Wen, K. Smith, A. L. Harris et al., Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas, Breast Cancer Research and Treatment, vol.256, issue.3, pp.35-293, 1995.
DOI : 10.1007/BF00665981

B. Busser, J. L. Coll, and A. Hurbin, The increasing role of amphiregulin in non-small cell lung cancer, Pathologie Biologie, vol.57, issue.7-8, pp.511-512, 2009.
DOI : 10.1016/j.patbio.2008.10.002

URL : https://hal.archives-ouvertes.fr/inserm-00333661

P. W. Cook, M. R. Pittelkow, W. W. Keeble, R. Graves-deal, R. J. Coffey-jr et al., Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas, Cancer Res, pp.52-3224, 1992.

T. Oikawa, J. Hitomi, A. Kono, E. Kaneko, and K. Yamaguchi, Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells, Int. J. Pancreatol, vol.18, pp.15-23, 1995.

E. M. Bindels, T. H. Van-der-kwast, V. Izadifar, D. K. Chopin, and W. I. De-boer, Functions of epidermal growth factor-like growth factors during human urothelial reepithelialization in vitro and the role of erbB2, Urol. Res, pp.30-240, 2002.

P. Geradts, A. Argani, and . Maitra, Identification of novel cellular targets in biliary tract cancers using global gene expression technology, Am. J. Pathol, vol.163, pp.217-229, 2003.

S. D. Billings, M. D. Southall, T. Li, P. W. Cook, L. Baldridge et al., Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors, The American Journal of Pathology, vol.163, issue.6, pp.163-2451, 2003.
DOI : 10.1016/S0002-9440(10)63600-0

O. C. , P. Rhys-evans, and S. Eccles, Expression and regulation of c-ERBB ligands in human head and neck squamous carcinoma cells, Int. J. Cancer, vol.88, pp.759-765, 2000.

T. Yamamoto, I. Fujita, T. Akisue, T. Marui, T. Nakatani et al., Amphiregulin and epidermal growth factor receptor expression in human malignant fibrous histiocytoma of soft tissues, Anticancer Res, vol.24, pp.1307-1310, 2004.

. Klein, Expression of EGF-family receptors and amphiregulin in multiple myeloma, Amphiregulin is a growth factor for myeloma cells, Oncogene, vol.24, pp.3512-3524, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00130206