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The multiple roles of amphiregulin in human cancer.

Benoit Busser 1, 2, * Lucie Sancey 1 Elisabeth Brambilla 3 Jean-Luc Coll 4 Amandine Hurbin 4 
* Corresponding author
3 INSERM U823, équipe 2 (Bases Moléculaires de la Progression des Cancers du Poumon)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble, Département d'anatomie et cythologie pathologique
Abstract : Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. Various studies have highlighted the functional role of AREG in several aspects of tumorigenesis, including self-sufficiency in generating growth signals, limitless replicative potential, tissue invasion and metastasis, angiogenesis, and resistance to apoptosis. The oncogenic activity of AREG has already been described in the most common human epithelial malignancies, such as lung, breast, colorectal, ovary and prostate carcinomas, as well as in some hematological and mesenchymal cancers. Furthermore, AREG is also involved in resistance to several cancer treatments. In this review, we describe the various roles of AREG in oncogenesis and discuss its translational potential, such as the development of anti-AREG treatments, based on AREG activity. In the last decade, independent groups have reported successful but sometimes contradictory results in relation to the potential of AREG to serve as a prognostic and/or predictive marker for oncology, especially with regard to anti-EGFR therapies. Thus, we also discuss the potential usefulness of using AREG as a therapeutic target and validated biomarker for predicting cancer outcomes or treatment efficacy.
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Submitted on : Tuesday, June 21, 2011 - 2:45:49 PM
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Benoit Busser, Lucie Sancey, Elisabeth Brambilla, Jean-Luc Coll, Amandine Hurbin. The multiple roles of amphiregulin in human cancer.. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 2011, 1816 (2), pp.119-131. ⟨10.1016/j.bbcan.2011.05.003⟩. ⟨inserm-00602082⟩



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