Skip to Main content Skip to Navigation
Journal articles

The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway

Abstract : Initially identified as the Caenorhabditis elegans PAR-4 homologue, the serine threonine kinase LKB1 is conserved throughout evolution and ubiquitously expressed. In humans, LKB1 is causally linked to the Peutz-Jeghers syndrome and is one of the most commonly mutated genes in several cancers like lung and cervical carcinomas. These observations have led to classify LKB1 as tumour suppressor gene. Although, considerable dark zones remain, an impressive leap in the understanding of LKB1 functions has been done during the last decade. Role of LKB1 as a major actor of the AMPK/mTOR pathway connecting cellular metabolism, cell growth and tumorigenesis has been extensively studied probably to the detriment of other functions of equal importance. This review will discuss about LKB1 activity regulation, its effectors and clues on their involvement in cell polarity.
Document type :
Journal articles
Complete list of metadata

Cited literature [86 references]  Display  Hide  Download
Contributor : Michael Sebbagh Connect in order to contact the contributor
Submitted on : Wednesday, June 20, 2012 - 7:00:05 AM
Last modification on : Sunday, June 26, 2022 - 12:38:41 AM
Long-term archiving on: : Friday, September 21, 2012 - 2:20:15 AM


Files produced by the author(s)




Michael Sebbagh, Sylviane Olschwang, Marie-Josée Santoni, Jean-Paul Borg. The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway. Familial Cancer, Springer Verlag (Germany), 2011, 10 (3), pp.415-24. ⟨10.1007/s10689-011-9457-7⟩. ⟨inserm-00601857⟩



Record views


Files downloads