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Journal articles
Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.
Claudine Fayard
1
Audrey Bonaventure
2
Isabelle Benatru
1
Emmanuel Roze
3
Julien Dumurgier
2, 4
Frédéric Moisan
2
Aïcha Soumaré
2
Jean Houssinot
5
Jean-Luc Dupupet
5
Jean-Louis Mazurie
6
Irina Balaboi
7
Jean-Luc Houeto
7
Elsa Krim
8
Danièle Ranoux
9
Marcel Goldberg
10
Ellen Imbernon
11
Thibault Moreau
1
Maurice Giroud
1
Christophe Tzourio
2
Alexis Elbaz
2, 11, *
*
Corresponding author
Claudine Fayard 1
Author
Audrey Bonaventure 2
Author
Isabelle Benatru 1
Author
Emmanuel Roze 3
Author
Julien Dumurgier 2, 4
Author
Frédéric Moisan 2
Author
Aïcha Soumaré 2
Author
Jean Houssinot 5
Author
Jean-Luc Dupupet 5
Author
Jean-Louis Mazurie 6
Author
Irina Balaboi 7
Author
Jean-Luc Houeto 7
Author
Thibault Moreau 1
Author
Maurice Giroud 1
Author
Christophe Tzourio 2
Author
Alexis Elbaz 2, 11
Correspondent author
1
Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) (CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
- CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
2
Neuroépidémiologie (GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U708 (101, rue de Tolbiac, 75013 Paris - France)
3
Fédération des Maladies du Système Nerveux (47-83, boulevard de l'Hôpital - 75651 PARIS Cedex 13 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
4
CMRR - Centres Mémoire de Ressource et de Recherche Paris Nord -IDF (Fernand Widal, F-75010 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Lariboisière (France)
6
Caisse départementale de la Gironde (F-33052, Bordeaux - France)
- Mutualité sociale agricole (France)
7
Service de neurologie [Poitiers] (France)
- CHU Poitiers - Centre hospitalier universitaire de Poitiers (2 Rue de la Milétrie, 86021 Poitiers - France)
9
Service de Neurologie [CHU Limoges] (Centre Hospitalier Universitaire Dupuytren 2 avenue Martin-Luther-King 87042 Limoges cedex - France)
- CHU Limoges (Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES - France)
10
CESP - Centre de recherche en épidémiologie et santé des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)
- UVSQ - Université de Versailles Saint-Quentin-en-Yvelines : UMR U1018 (55 avenue de Paris - 78035 Versailles cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1018 (101, rue de Tolbiac, 75013 Paris - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Paul Brousse (12 Avenue Paul Vaillant Couturier, 94800 Villejuif - France)
11
DST-InVS - Département santé travail (12, rue du Val d'Osne 94415 Saint-Maurice Cedex - France)
- INVS - Institut de Veille Sanitaire (12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France - France)
Abstract : Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients ≥70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France.
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Journal articles
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https://www.hal.inserm.fr/inserm-00598387
Contributor : Annie Schmaus <>
Submitted on : Monday, June 6, 2011 - 2:08:58 PM
Last modification on : Thursday, December 10, 2020 - 3:44:12 AM
Long-term archiving on: : Sunday, December 4, 2016 - 9:06:02 AM
Contributor : Annie Schmaus <>
Submitted on : Monday, June 6, 2011 - 2:08:58 PM
Last modification on : Thursday, December 10, 2020 - 3:44:12 AM
Long-term archiving on: : Sunday, December 4, 2016 - 9:06:02 AM
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Identifiers
- HAL Id : inserm-00598387, version 1
- DOI : 10.1016/j.parkreldis.2011.04.020
- PUBMED : 21612970
Citation
Claudine Fayard, Audrey Bonaventure, Isabelle Benatru, Emmanuel Roze, Julien Dumurgier, et al.. Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.. Parkinsonism and Related Disorders, Elsevier, 2011, 17 (7), pp.543-6. ⟨10.1016/j.parkreldis.2011.04.020⟩. ⟨inserm-00598387⟩
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