A. Drzezga, T. Grimmer, G. Henriksen, M. Muhlau, R. Perneczky et al., Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease, Neurology, vol.72, issue.17, pp.1487-1494, 2009.
DOI : 10.1212/WNL.0b013e3181a2e8d0

E. Kok, S. Haikonen, T. Luoto, H. Huhtala, S. Goebeler et al., Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age, Annals of Neurology, vol.15, issue.6, pp.650-657, 2009.
DOI : 10.1002/ana.21696

L. Jofre-monseny, A. Minihane, G. Rimbach, H. Querfurth, and F. Laferla, Impact of apoE genotype on oxidative stress, inflammation and disease risk, Molecular Nutrition & Food Research, vol.109, issue.1, pp.131-145, 2008.
DOI : 10.1002/mnfr.200700322

T. Montine, M. Neely, J. Quinn, M. Beal, W. Markesbery et al., Lipid peroxidation in aging brain and Alzheimer???s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on ???Causes and Consequences of Oxidative Stress in Alzheimer???s Disease.??? The full list of papers may be found on the homepage of the journal., Free Radical Biology and Medicine, vol.33, issue.5, pp.620-626, 2002.
DOI : 10.1016/S0891-5849(02)00807-9

W. Markesbery, R. Kryscio, M. Lovell, and J. Morrow, Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment, Annals of Neurology, vol.24, issue.5, pp.730-735, 2005.
DOI : 10.1002/ana.20629

C. Lauderback, J. Kanski, J. Hackett, N. Maeda, M. Kindy et al., Apolipoprotein E modulates Alzheimer???s A??(1???42)-induced oxidative damage to synaptosomes in an allele-specific manner, Brain Research, vol.924, issue.1, pp.90-97, 2002.
DOI : 10.1016/S0006-8993(01)03228-0

M. Miyata and J. Smith, Apolipoprotein E allele???specific antioxidant activity and effects on cytotoxicity by oxidative insults and ?????amyloid peptides, Nature Genetics, vol.263, issue.1, pp.55-61, 1996.
DOI : 10.1016/S0076-6879(78)52032-6

H. Ortega, P. Castilla, D. Gomez-coronado, C. Garces, M. Benavente et al., Influence of apolipoprotein E genotype on fat-soluble plasma antioxidants in Spanish children, Am J Clin Nutr, vol.81, pp.624-632, 2005.

E. Mas, A. Dupuy, S. Artero, F. Portet, J. Cristol et al., Functional Vitamin E Deficiency in <i>ApoE4</i> Patients with Alzheimer???s Disease, Dementia and Geriatric Cognitive Disorders, vol.21, issue.3, pp.198-204, 2006.
DOI : 10.1159/000090868

M. Morris, D. Evans, J. Bienias, C. Tangney, D. Bennett et al., Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study, JAMA, vol.287, issue.24, pp.3230-3237, 2002.
DOI : 10.1001/jama.287.24.3230

P. Hu, P. Bretsky, E. Crimmins, J. Guralnik, D. Reuben et al., Association Between Serum Beta-Carotene Levels and Decline of Cognitive Function in High-Functioning Older Persons With or Without Apolipoprotein E 4 Alleles: MacArthur Studies of Successful Aging, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.61, issue.6, pp.616-636, 2006.
DOI : 10.1093/gerona/61.6.616

S. Gao, J. Y. Hall, K. Liang, C. Unverzagt, F. Ma et al., Selenium level is associated with apoE ??4 in rural elderly Chinese, Public Health Nutrition, vol.42, issue.12, pp.2371-2377
DOI : 10.1016/j.bbrc.2007.10.189

H. Kharrazi, A. Vaisi-raygani, Z. Rahimi, H. Tavilani, M. Aminian et al., Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease, Clinical Biochemistry, vol.41, issue.12, pp.932-936, 2008.
DOI : 10.1016/j.clinbiochem.2008.05.001

C. Holmes, C. Cunningham, E. Zotova, J. Woolford, C. Dean et al., Systemic inflammation and disease progression in Alzheimer disease, Neurology, vol.73, issue.10, pp.768-774, 2009.
DOI : 10.1212/WNL.0b013e3181b6bb95

C. Finch and T. Morgan, Systemic Inflammation, Infection, ApoE Alleles, and Alzheimer Disease: A Position Paper, Current Alzheimer Research, vol.4, issue.2, pp.185-194, 2007.
DOI : 10.2174/156720507780362254

H. Belinson and D. Michaelson, ApoE4-dependent A??-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum, Journal of Neural Transmission, vol.45, issue.3, pp.1427-1461, 2009.
DOI : 10.1007/s00702-009-0218-9

D. Chasman, P. Kozlowski, R. Zee, D. Kwiatkowski, and P. Ridker, Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein, Genes and Immunity, vol.70, issue.3, pp.211-219, 2006.
DOI : 10.1038/sj.gene.6364289

G. Ravaglia, P. Forti, F. Maioli, M. Chiappelli, F. Montesi et al., Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly, Am J Clin Nutr, vol.84, pp.1473-80, 2006.

R. Rontu, P. Ojala, A. Hervonen, S. Goebeler, P. Karhunen et al., Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians, Clinical Endocrinology, vol.46, issue.3, pp.265-270, 2006.
DOI : 10.1016/0304-3940(95)12190-0

J. Noble, J. Manly, N. Schupf, M. Tang, R. Mayeux et al., Association of C-Reactive Protein With Cognitive Impairment, Archives of Neurology, vol.67, issue.1, pp.87-92, 2010.
DOI : 10.1001/archneurol.2009.308

H. Mu and C. Hoy, The digestion of dietary triacylglycerols, Progress in Lipid Research, vol.43, issue.2, pp.105-138, 2004.
DOI : 10.1016/S0163-7827(03)00050-X

C. Hooijmans and A. Kiliaan, Fatty acids, lipid metabolism and Alzheimer pathology, European Journal of Pharmacology, vol.585, issue.1, pp.176-196, 2008.
DOI : 10.1016/j.ejphar.2007.11.081
URL : http://repository.ubn.ru.nl/bitstream/2066/70281/1/70281.pdf

R. Mahley and S. Rall, E: Far More Than a Lipid Transport Protein, Annual Review of Genomics and Human Genetics, vol.1, issue.1, pp.507-537, 2000.
DOI : 10.1146/annurev.genom.1.1.507

L. Shobab, G. Hsiung, and H. Feldman, Cholesterol in Alzheimer's disease, The Lancet Neurology, vol.4, issue.12, pp.841-852, 2005.
DOI : 10.1016/S1474-4422(05)70248-9

R. Lane and M. Farlow, Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease, The Journal of Lipid Research, vol.46, issue.5, pp.949-68, 2005.
DOI : 10.1194/jlr.M400486-JLR200

P. Garry, R. Baumgartner, S. Brodie, G. Montoya, H. Liang et al., Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene, Clin Chem, vol.45, pp.1214-1223, 1999.

H. Staehelin, P. Perrigchiello, C. Mitrache, A. Miserez, and W. Perrig, Apolipoprotein E genotypes and cognitive functions in healthy elderly persons, Acta Neurologica Scandinavica, vol.43, issue.7, pp.53-60, 1999.
DOI : 10.1111/j.1600-0404.1999.tb00723.x

H. Wehr, T. Parnowski, S. Puzynski, M. Bednarskamakaruk, M. Bisko et al., Apolipoprotein E Genotype and Lipid and Lipoprotein Levels in Dementia, Dementia and Geriatric Cognitive Disorders, vol.11, issue.2, pp.70-73, 2000.
DOI : 10.1159/000017217

E. Giltay, A. Van-reedt-dortland, A. Nissinen, S. Giampaoli, T. Van-veen et al., Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: The FINE study, Journal of Affective Disorders, vol.115, issue.3, pp.471-477, 2009.
DOI : 10.1016/j.jad.2008.10.004

Y. Kuo, M. Emmerling, C. Bisgaier, A. Essenburg, H. Lampert et al., Elevated Low-Density Lipoprotein in Alzheimer's Disease Correlates with Brain A?? 1???42 Levels, Biochemical and Biophysical Research Communications, vol.252, issue.3, pp.711-715, 1998.
DOI : 10.1006/bbrc.1998.9652

M. Kivipelto, E. Helkala, M. Laakso, T. Hanninen, M. Hallikainen et al., Apolipoprotein E ??4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease, Annals of Internal Medicine, vol.137, issue.3, pp.149-155, 2002.
DOI : 10.7326/0003-4819-137-3-200208060-00006

A. Solomon, M. Kivipelto, B. Wolozin, J. Zhou, and R. Whitmer, Midlife Serum Cholesterol and Increased Risk of Alzheimer&rsquo;s and Vascular Dementia Three Decades Later, Dementia and Geriatric Cognitive Disorders, vol.28, issue.1
DOI : 10.1159/000231980

A. Solomon, I. Kareholt, T. Ngandu, B. Winblad, A. Nissinen et al., Serum cholesterol changes after midlife and late-life cognition: Twenty-one-year follow-up study, Neurology, vol.68, issue.10, pp.751-756, 2007.
DOI : 10.1212/01.wnl.0000256368.57375.b7

R. Stewart, L. White, Q. Xue, and L. Launer, Twenty-six???Year Change in Total Cholesterol Levels and Incident Dementia, Archives of Neurology, vol.64, issue.1, pp.103-107, 2007.
DOI : 10.1001/archneur.64.1.103

R. Evans, C. Emsley, S. Gao, A. Sahota, K. Hall et al., Serum cholesterol, APOE genotype, and the risk of Alzheimer s disease: A population-based study of

C. Dufouil, F. Richard, N. Fievet, J. Dartigues, K. Ritchie et al., APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: The Three-City Study, Neurology, vol.64, issue.9
DOI : 10.1212/01.WNL.0000160114.42643.31
URL : https://hal.archives-ouvertes.fr/inserm-00175952

R. West, M. Beeri, J. Schmeidler, C. Hannigan, G. Angelo et al., Better Memory Functioning Associated With Higher Total and Low-Density Lipoprotein Cholesterol Levels in Very Elderly Subjects Without the Apolipoprotein e4 Allele, The American Journal of Geriatric Psychiatry, vol.16, issue.9, pp.781-785, 2008.
DOI : 10.1097/JGP.0b013e3181812790

T. Van-den-kommer, M. Dik, H. Comijs, K. Fassbender, D. Lutjohann et al., Total cholesterol and oxysterols: Early markers for cognitive decline in elderly?, Neurobiology of Aging, vol.30, issue.4, pp.534-545, 2009.
DOI : 10.1016/j.neurobiolaging.2007.08.005

A. Minihane, L. Jofre-monseny, E. Olano-martin, and G. Rimbach, ApoE genotype, cardiovascular risk and responsiveness to dietary fat manipulation, Proceedings of the Nutrition Society, vol.15, issue.02, pp.183-97, 2007.
DOI : 10.1016/S0006-3495(92)81698-3

M. Plourde, M. Fortier, M. Vandal, J. Tremblay-mercier, and E. Freemantle, Unresolved issues in the link between docosahexaenoic acid and Alzheimer s disease

J. Kim, J. Basak, and D. Holtzman, The Role of Apolipoprotein E in Alzheimer's Disease, Neuron, vol.63, issue.3, pp.287-303, 2009.
DOI : 10.1016/j.neuron.2009.06.026

T. Fraser, H. Tayler, and S. Love, Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer???s Disease, Neurochemical Research, vol.26, issue.Pt 3, pp.503-516, 2010.
DOI : 10.1007/s11064-009-0087-5

T. Huang, P. Zandi, K. Tucker, A. Fitzpatrick, L. Kuller et al., Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4

M. Beydoun, J. Kaufman, J. Satia, R. W. Folsom, and A. , Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study, Am J Clin Nutr, vol.85, pp.1103-1111, 2007.

L. Whalley, I. Deary, J. Starr, K. Wahle, K. Rance et al., n-3 Fatty acid erythrocyte membrane content, APOE epsilon4, and cognitive variation: an observational follow-up study in late adulthood, Am J Clin Nutr, vol.87, pp.449-454, 2008.

C. Samieri, C. Feart, C. Proust-lima, E. Peuchant, J. Dartigues et al., Omega-3 fatty acids and cognitive decline: modulation by ApoE epsilon4 allele and depression, Neurobiol Aging

M. Laitinen, T. Ngandu, S. Rovio, E. Helkala, U. Uusitalo et al., Fat intake at midlife and risk of dementia and Alzheimer s disease: a population-based study

M. Kivipelto, S. Rovio, T. Ngandu, I. Eskelinen, M. Winblad et al., Apolipoprotein epsilon4 magnifies lifestyle risks for dementia: a population-based study, J

C. Samieri, C. Feart, L. Letenneur, J. Dartigues, K. Peres et al., Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk, Am J Clin Nutr, vol.88, pp.714-721, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00321926

J. Quinn, R. Raman, R. Thomas, K. Yurko-mauro, E. Nelson et al., Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease, JAMA, vol.304, issue.17, pp.1903-1911, 2010.
DOI : 10.1001/jama.2010.1510

G. Cole and S. Frautschy, DHA May Prevent Age-Related Dementia, Journal of Nutrition, vol.140, issue.4, pp.869-874, 2010.
DOI : 10.3945/jn.109.113910

A. Polozova, N. Salem, and . Jr, Role of Liver and Plasma Lipoproteins in Selective Transport of n-3 Fatty Acids to Tissues: A Comparative Study of 14C-DHA and 3H-Oleic Acid Tracers, Journal of Molecular Neuroscience, vol.31, issue.3, pp.56-66, 2007.
DOI : 10.1007/s12031-007-0039-y

J. Hamilton and K. Brunaldi, A Model for Fatty Acid Transport into the Brain, Journal of Molecular Neuroscience, vol.35, issue.1, pp.12-19, 2007.
DOI : 10.1007/s12031-007-0050-3

A. Spector, Plasma Free Fatty Acid and Lipoproteins as Sources of Polyunsaturated Fatty Acid for the Brain, Journal of Molecular Neuroscience, vol.16, issue.2-3, pp.159-65
DOI : 10.1385/JMN:16:2-3:159

J. Hamilton, C. Hillard, A. Spector, and P. Watkins, Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Application to Neurological Disorders, Journal of Molecular Neuroscience, vol.33, issue.Suppl, pp.2-11, 2007.
DOI : 10.1007/s12031-007-0060-1

M. Plourde, M. Vohl, M. Vandal, P. Couture, S. Lemieux et al., Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE 4 but not by the common PPAR-?? L162V polymorphism in men, British Journal of Nutrition, vol.31, issue.08, pp.1121-1124, 2009.
DOI : 10.1159/000137555

H. Sadou, C. Leger, B. Descomps, J. Barjon, L. Monnier et al., Differential incorporation of fish-oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long-term study in healthy humans, Am J Clin Nutr, vol.62, pp.1193-200, 1995.

M. Gibney and E. Daly, The incorporation of n-3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers, Eur J

R. Heath, F. Karpe, R. Milne, G. Burdge, S. Wootton et al., Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period, The Journal of Lipid Research, vol.44, issue.11, pp.2065-72, 2003.
DOI : 10.1194/jlr.M300167-JLR200

K. Motoyama, J. Curb, T. Kadowaki, A. El-saed, R. Abbott et al., Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men, American Journal of Clinical Nutrition, vol.90, issue.1, pp.49-55, 2009.
DOI : 10.3945/ajcn.2008.26761

E. Anil, The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype, Proceedings of the Nutrition Society, vol.12, issue.01, pp.60-68, 2007.
DOI : 10.1017/S0029665107005307

L. Masson, G. Mcneill, and A. Avenell, Genetic variation and the lipid response to dietary intervention: a systematic review, Am J Clin Nutr, vol.77, pp.1098-1111, 2003.

E. Olano-martin, E. Anil, M. Caslake, C. Packard, D. Bedford et al., Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil, Atherosclerosis, vol.209, issue.1, pp.104-114, 2010.
DOI : 10.1016/j.atherosclerosis.2009.08.024

K. Nagao and T. Yanagita, Bioactive lipids in metabolic syndrome, Progress in Lipid Research, vol.47, issue.2, pp.127-2008
DOI : 10.1016/j.plipres.2007.12.002

R. Paula, V. Souza, A. Benedet, E. Souza, J. Toledo et al., Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women, Molecular and Cellular Biochemistry, vol.125, issue.Suppl 1
DOI : 10.1007/s11010-009-0313-0

M. Caslake, E. Miles, B. Kofler, G. Lietz, P. Curtis et al., Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study

S. Farr, K. Yamada, D. Butterfield, H. Abdul, L. Xu et al., Obesity and Hypertriglyceridemia Produce Cognitive Impairment, Endocrinology, vol.149, issue.5, pp.2628-2664, 2008.
DOI : 10.1210/en.2007-1722
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329289

C. Raffaitin, H. Gin, J. Empana, C. Helmer, C. Berr et al., Metabolic syndrome and risk for incident Alzheimer s disease or vascular dementia: the Three -City ' study . Diabetes Care, pp.169-174, 2009.

J. Cooper, Dietary Lipids in the Aetiology of Alzheimer???s Disease, Drugs & Aging, vol.6, issue.5, pp.399-418, 2003.
DOI : 10.2165/00002512-200320060-00001

A. Gomezramos, J. Diaznido, M. Smith, G. Perry, and J. Avila, Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells, Journal of Neuroscience Research, vol.123, issue.6, pp.863-870, 2003.
DOI : 10.1002/jnr.10525

C. Szekely, J. Breitner, A. Fitzpatrick, T. Rea, B. Psaty et al., NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type, Neurology, vol.70, issue.1, pp.17-24, 2008.
DOI : 10.1212/01.wnl.0000284596.95156.48

Y. Freund-levi, E. Hjorth, C. Lindberg, T. Cederholm, G. Faxen-irving et al., Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer&rsquo;s Disease: The OmegAD Study, Dementia and Geriatric Cognitive Disorders, vol.27, issue.5, pp.481-490, 2009.
DOI : 10.1159/000218081

G. Kalpouzos, G. Chetelat, J. Baron, B. Landeau, K. Mevel et al., Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging, Neurobiology of Aging, vol.30, issue.1, pp.112-136, 2009.
DOI : 10.1016/j.neurobiolaging.2007.05.019
URL : https://hal.archives-ouvertes.fr/inserm-00277881

G. Kalpouzos, F. Eustache, V. De-la-sayette, F. Viader, G. Chetelat et al., Working memory and FDG???PET dissociate early and late onset Alzheimer disease patients, Journal of Neurology, vol.9, issue.5, pp.548-58, 2005.
DOI : 10.1007/s00415-005-0685-3

E. Reiman, K. Chen, G. Alexander, R. Caselli, D. Bandy et al., Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia, Proceedings of the National Academy of Sciences, vol.101, issue.1, pp.284-293, 2004.
DOI : 10.1073/pnas.2635903100

O. Owen, A. Morgan, H. Kemp, J. Sullivan, M. Herrera et al., Brain Metabolism during Fasting*, Journal of Clinical Investigation, vol.46, issue.10, pp.1589-95, 1967.
DOI : 10.1172/JCI105650

E. Freemantle, M. Vandal, J. Tremblay-mercier, M. Plourde, J. Poirier et al., Metabolic response to a ketogenic breakfast in the healthy elderly, The Journal of Nutrition, Health and Aging, vol.42, issue.Suppl1, pp.293-2009
DOI : 10.1007/s12603-009-0026-9

M. Reger, S. Henderson, C. Hale, B. Cholerton, L. Baker et al., Effects of ??-hydroxybutyrate on cognition in memory-impaired adults, Neurobiology of Aging, vol.25, issue.3, pp.311-314, 2004.
DOI : 10.1016/S0197-4580(03)00087-3

S. Henderson, J. Vogel, L. Barr, F. Garvin, J. Jones et al., Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial, Nutrition & Metabolism, vol.6, issue.1, pp.31-2009
DOI : 10.1186/1743-7075-6-31

K. Tucker, N. Qiao, T. Scott, I. Rosenberg, and A. Spiro, High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study, Am J Clin Nutr, vol.82, pp.627-662, 2005.

R. Clarke, J. Birks, E. Nexo, P. Ueland, J. Schneede et al., Low vitamin B-12 status and risk of cognitive decline in older adults, Am J Clin Nutr, vol.86, pp.1384-1391, 2007.

M. Haan, J. Miller, A. Aiello, R. Whitmer, W. Jagust et al., Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging, Am J Clin Nutr, vol.85, pp.511-518, 2007.

S. Seshadri, A. Beiser, J. Selhub, P. Jacques, I. Rosenberg et al., Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease, New England Journal of Medicine, vol.346, issue.7, pp.476-83, 2002.
DOI : 10.1056/NEJMoa011613

G. Ravaglia, P. Forti, F. Maioli, M. Martelli, L. Servadei et al., Homocysteine and folate as risk factors for dementia and Alzheimer disease, Am J Clin Nutr, vol.82, pp.636-679, 2005.

G. Ravaglia, P. Forti, F. Maioli, M. Chiappelli, F. Montesi et al., Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging, Neurobiology of Aging, vol.28, issue.12, pp.1810-1820, 2007.
DOI : 10.1016/j.neurobiolaging.2006.08.012

M. Elias, M. Robbins, M. Budge, P. Elias, G. Dore et al., Homocysteine and cognitive performance: Modification by the ApoE genotype, Neuroscience Letters, vol.430, issue.1, pp.64-69, 2008.
DOI : 10.1016/j.neulet.2007.10.021

D. Li, X. Yu, H. Xie, Y. Zhang, Q. Wang et al., Platelet phospholipid n???3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.76, issue.5, pp.293-297, 2007.
DOI : 10.1016/j.plefa.2007.02.003

T. Huang, M. Wahlqvist, and D. Li, Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in??methionine metabolism, Nutrition, vol.26, issue.1, pp.112-121, 2010.
DOI : 10.1016/j.nut.2009.05.015

A. Olszewski and K. Mccully, Fish oil decreases serum homocysteine in hyperlipemic men, Coronary Artery Disease, vol.4, issue.1, pp.53-60, 1993.
DOI : 10.1097/00019501-199301000-00007

M. Selley, A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease, Neurobiology of Aging, vol.28, issue.12, pp.1834-1843, 2007.
DOI : 10.1016/j.neurobiolaging.2006.08.003

A. Kanaya, K. Lindquist, T. Harris, L. Launer, C. Rosano et al., Total and Regional Adiposity and Cognitive Change in Older Adults, Archives of Neurology, vol.66, issue.3, pp.329-364, 2009.
DOI : 10.1001/archneurol.2008.570

S. Sabia, M. Kivimaki, M. Shipley, M. Marmot, and A. Singh-manoux, Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study, American Journal of Clinical Nutrition, vol.89, issue.2, pp.601-607, 2009.
DOI : 10.3945/ajcn.2008.26482
URL : https://hal.archives-ouvertes.fr/inserm-00353140

R. Whitmer, D. Gustafson, E. Barrett-connor, M. Haan, E. Gunderson et al., Central obesity and increased risk of dementia more than three decades later, Neurology, vol.71, issue.14
DOI : 10.1212/01.wnl.0000306313.89165.ef

A. Fitzpatrick, L. Kuller, O. Lopez, P. Diehr, . Meara-'es et al., Midlife and Late-Life Obesity and the Risk of Dementia, Archives of Neurology, vol.66, issue.3
DOI : 10.1001/archneurol.2008.582

M. Kivipelto, T. Ngandu, L. Fratiglioni, M. Viitanen, I. Kareholt et al., Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease, Archives of Neurology, vol.62, issue.10, pp.1556-60, 2005.
DOI : 10.1001/archneur.62.10.1556

H. Kim, M. Della-fera, J. Lin, and C. Baile, Docosahexaenoic Acid Inhibits Adipocyte Differentiation and Induces Apoptosis in 3T3-L1 Preadipocytes, J Nutr, vol.136, pp.2965-2969, 2006.

M. Micallef, I. Munro, M. Phang, and M. Garg, Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity, British Journal of Nutrition, vol.22, issue.09, pp.1370-1374, 2009.
DOI : 10.1210/er.2005-0011

K. Kypreos, I. Karagiannides, E. Fotiadou, E. Karavia, M. Brinkmeier et al., Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity, FEBS Journal, vol.11, issue.20, pp.5720-5728, 2009.
DOI : 10.1111/j.1742-4658.2009.07301.x

J. Luchsinger, M. Tang, S. Shea, and R. Mayeux, Caloric Intake and the Risk of Alzheimer Disease, Archives of Neurology, vol.59, issue.8, pp.1258-1263, 2002.
DOI : 10.1001/archneur.59.8.1258

M. Beydoun, H. Beydoun, and Y. Wang, Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis, Obesity Reviews, vol.42, issue.3, pp.204-222, 2008.
DOI : 10.1046/j.1532-5415.2002.50507.x

F. Nourhashemi, V. Deschamps, S. Larrieu, L. Letenneur, J. Dartigues et al., Body mass index and incidence of dementia: The PAQUID study, Neurology, vol.60, issue.1
DOI : 10.1212/01.WNL.0000038910.46217.AA

A. Atti, K. Palmer, S. Volpato, B. Winblad, D. Ronchi et al., Late-Life Body Mass Index and Dementia Incidence: Nine-Year Follow-Up Data from the Kungsholmen Project, Journal of the American Geriatrics Society, vol.62, issue.1, pp.111-116, 2008.
DOI : 10.1111/j.1532-5415.2007.01458.x

H. Wengreen, C. Neilson, R. Munger, and C. Corcoran, Diet Quality Is Associated with Better Cognitive Test Performance among Aging Men and Women, Journal of Nutrition, vol.139, issue.10, pp.1944-1949, 2009.
DOI : 10.3945/jn.109.106427

M. Vanhanen, M. Kivipelto, K. Koivisto, J. Kuusisto, L. Mykk-nen-Ä et al., APOE-??4 is associated with weight loss in women with AD: A population-based study, Neurology, vol.56, issue.5, pp.655-659, 2001.
DOI : 10.1212/WNL.56.5.655

F. Irving, G. Freund-levi, Y. Eriksdotter-jonhagen, M. Basun, H. Brismar et al., Omega-3 Fatty Acid Supplementation Effects on Weight and Appetite in Patients with Alzheimer s Disease: The Omega-3 Alzheimer s Disease Study, J Am Geriatr Soc, 2008.

A. Jorm, Is Depression a Risk Factor for Dementia or Cognitive Decline?, Gerontology, vol.46, issue.4, pp.219-227, 2000.
DOI : 10.1159/000022163

J. Luchsinger, L. Honig, M. Tang, and D. Devanand, Depressive symptoms, vascular risk factors, and Alzheimer's disease, International Journal of Geriatric Psychiatry, vol.56, issue.5, pp.922-928
DOI : 10.1002/gps.2006

P. Modrego and J. Ferrandez, Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type -A prospective cohort study, Arch Neurol, vol.61, pp.1290-1293, 2004.

M. Slifer, E. Martin, J. Gilbert, J. Haines, and M. Pericak-vance, Resolving the relationship between ApolipoproteinE and depression, Neuroscience Letters, vol.455, issue.2, pp.116-119, 2009.
DOI : 10.1016/j.neulet.2009.03.007

H. Tiemeier, H. Van-tuijl, A. Hofman, A. Kiliaan, and M. Breteler, Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study

J. Bourre, Dietary Omega-3 fatty acids and psychiatry: mood, behaviour, stress, depression, dementia and aging, J Nutr Health Aging, vol.9, pp.31-38, 2005.

P. Astorg, A. Couthouis, S. Bertrais, N. Arnault, P. Meneton et al., Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.78, issue.3, pp.171-2008
DOI : 10.1016/j.plefa.2008.01.003

C. Feart, E. Peuchant, L. Letenneur, C. Samieri, D. Montagnier et al., Plasma eicosapentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City Study, Am J Clin Nutr, vol.87, pp.1156-1162, 2008.

J. Hibbeln, Fish consumption and major depression, The Lancet, vol.351, issue.9110, pp.1213-1998
DOI : 10.1016/S0140-6736(05)79168-6

A. Tanskanen, J. Hibbeln, J. Tuomilehto, A. Uutela, A. Haukkala et al., Fish Consumption and Depressive Symptoms in the General Population in Finland, Psychiatric Services, vol.52, issue.4
DOI : 10.1176/appi.ps.52.4.529

P. Lin and K. Su, A Meta-Analytic Review of Double-Blind, Placebo-Controlled Trials of Antidepressant Efficacy of Omega-3 Fatty Acids, The Journal of Clinical Psychiatry, vol.68, issue.07, pp.1056-61
DOI : 10.4088/JCP.v68n0712

O. Van-de-rest, J. Geleijnse, F. Kok, W. Van-staveren, W. Hoefnagels et al., Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr, vol.88, pp.706-713, 2008.

M. Lucas, G. Asselin, C. Merette, M. Poulin, and S. Dodin, Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial, American Journal of Clinical Nutrition, vol.89, issue.2, pp.641-651, 2009.
DOI : 10.3945/ajcn.2008.26749

Y. Freund-levi, H. Basun, T. Cederholm, G. Fax-n-irving-É, A. Mikaela et al., Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms, International Journal of Geriatric Psychiatry, vol.45, issue.2, pp.161-169, 2008.
DOI : 10.1002/gps.1857

E. Corder and J. Caskey, Early intervention in Alzheimer disease: The importance of APOE4 plus family history, Neurology, vol.73, issue.24, pp.2054-2055, 2009.
DOI : 10.1212/WNL.0b013e3181c67870

Y. Stern, Cognitive reserve and Alzheimer disease . Alz Dis Assoc Disorder, pp.112-117, 2006.