Longitudinal Ambulatory Measurements of Gait Abnormality in Dystrophin-Deficient Dogs. - Archive ouverte HAL Access content directly
Journal Articles BMC Musculoskeletal Disorders Year : 2011

Longitudinal Ambulatory Measurements of Gait Abnormality in Dystrophin-Deficient Dogs.

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Inès Barthélémy
Pablo Aguilar
  • Function : Author
  • PersonId : 901905
Ane Uriarte
  • Function : Author
  • PersonId : 901906
Matthias Le Chevoir
  • Function : Author
  • PersonId : 901907
Jean-Laurent Thibaud
  • Function : Author
  • PersonId : 901908
Thomas Voit
  • Function : Author
  • PersonId : 901909
Stéphane Blot

Abstract

ABSTRACT: BACKGROUND: This study aimed to measure the gait abnormalities in GRMD (Golden retriever muscular dystrophy) dogs during growth and disease progression using an ambulatory gait analyzer (3D-accelerometers) as a possible tool to assess the effects of a therapeutic intervention. METHODS: Six healthy and twelve GRMD dogs were evaluated twice monthly, from the age of two to nine months. The evolution of each gait variable previously shown to be modified in control and dystrophin-deficient adults was assessed using two-ways variance analysis (age, clinical status) with repeated measurements. A principal component analysis (PCA) was applied to perfect multivariate data interpretation. RESULTS: Speed, stride length, total power and force significantly already decreased (p < 0.01) at the age of 2 months. The other gait variables (stride frequency, relative power distributions along the three axes) became modified at later stages. Using the PCA analysis, a global gait index taking into account the main gait variables was calculated, and was also consistent to detect the early changes in the GRMD gait patterns, as well as the progressive degradation of gait quality. CONCLUSION: The gait variables measured by the accelerometers were sensitive to early detect and follow the gait disorders and mirrored the heterogeneity of clinical presentations, giving sense to monitor gait in GRMD dogs during progression of the disease and pre-clinical therapeutic trials.
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Dates and versions

inserm-00596534 , version 1 (27-05-2011)

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Inès Barthélémy, Eric Barrey, Pablo Aguilar, Ane Uriarte, Matthias Le Chevoir, et al.. Longitudinal Ambulatory Measurements of Gait Abnormality in Dystrophin-Deficient Dogs.. BMC Musculoskeletal Disorders, 2011, 12 (1), pp.75. ⟨10.1186/1471-2474-12-75⟩. ⟨inserm-00596534⟩
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