RAD50 function is essential for telomere maintenance in Arabidopsis. - Archive ouverte HAL Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2001

RAD50 function is essential for telomere maintenance in Arabidopsis.

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Abstract

We have identified and characterized an Arabidopsis thaliana rad50 mutant plant containing a T-DNA insertion in the AtRAD50 gene and showing both meiotic and DNA repair defects. We report here that rad50/rad50 mutant cells show a progressive shortening of telomeric DNA relative to heterozygous rad50/RAD50 controls and that the mutant cell population rapidly enters a crisis, with the majority of the cells dying. Surviving rad50 mutant cells have longer telomeres than wild-type cells, indicating the existence in plants of an alternative RAD50-independent mechanism for telomere maintenance. These results report the role of a protein essential for double-strand break repair in telomere maintenance in higher eukaryotes.

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inserm-00595834 , version 1 (25-05-2011)

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Maria Eugenia Gallego, Charles I. White. RAD50 function is essential for telomere maintenance in Arabidopsis.. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (4), pp.1711-6. ⟨10.1073/pnas.98.4.1711⟩. ⟨inserm-00595834⟩
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