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RAD50 function is essential for telomere maintenance in Arabidopsis.

Abstract : We have identified and characterized an Arabidopsis thaliana rad50 mutant plant containing a T-DNA insertion in the AtRAD50 gene and showing both meiotic and DNA repair defects. We report here that rad50/rad50 mutant cells show a progressive shortening of telomeric DNA relative to heterozygous rad50/RAD50 controls and that the mutant cell population rapidly enters a crisis, with the majority of the cells dying. Surviving rad50 mutant cells have longer telomeres than wild-type cells, indicating the existence in plants of an alternative RAD50-independent mechanism for telomere maintenance. These results report the role of a protein essential for double-strand break repair in telomere maintenance in higher eukaryotes.
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Contributor : Charles White <>
Submitted on : Wednesday, May 25, 2011 - 4:22:57 PM
Last modification on : Tuesday, April 20, 2021 - 11:22:02 AM

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Maria Eugenia Gallego, Charles White. RAD50 function is essential for telomere maintenance in Arabidopsis.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2001, 98 (4), pp.1711-6. ⟨10.1073/pnas.98.4.1711⟩. ⟨inserm-00595834⟩



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