RAD50 function is essential for telomere maintenance in Arabidopsis.

Maria Eugenia Gallego 1 Charles White 1
1 GReD - Génétique, reproduction et développement
Abstract : We have identified and characterized an Arabidopsis thaliana rad50 mutant plant containing a T-DNA insertion in the AtRAD50 gene and showing both meiotic and DNA repair defects. We report here that rad50/rad50 mutant cells show a progressive shortening of telomeric DNA relative to heterozygous rad50/RAD50 controls and that the mutant cell population rapidly enters a crisis, with the majority of the cells dying. Surviving rad50 mutant cells have longer telomeres than wild-type cells, indicating the existence in plants of an alternative RAD50-independent mechanism for telomere maintenance. These results report the role of a protein essential for double-strand break repair in telomere maintenance in higher eukaryotes.
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Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2001, 98 (4), pp.1711-6. 〈10.1073/pnas.98.4.1711〉
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http://www.hal.inserm.fr/inserm-00595834
Contributeur : Charles White <>
Soumis le : mercredi 25 mai 2011 - 16:22:57
Dernière modification le : jeudi 11 janvier 2018 - 06:23:14

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Maria Eugenia Gallego, Charles White. RAD50 function is essential for telomere maintenance in Arabidopsis.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2001, 98 (4), pp.1711-6. 〈10.1073/pnas.98.4.1711〉. 〈inserm-00595834〉

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