Skip to Main content Skip to Navigation
Journal articles

RAD50 function is essential for telomere maintenance in Arabidopsis.

Abstract : We have identified and characterized an Arabidopsis thaliana rad50 mutant plant containing a T-DNA insertion in the AtRAD50 gene and showing both meiotic and DNA repair defects. We report here that rad50/rad50 mutant cells show a progressive shortening of telomeric DNA relative to heterozygous rad50/RAD50 controls and that the mutant cell population rapidly enters a crisis, with the majority of the cells dying. Surviving rad50 mutant cells have longer telomeres than wild-type cells, indicating the existence in plants of an alternative RAD50-independent mechanism for telomere maintenance. These results report the role of a protein essential for double-strand break repair in telomere maintenance in higher eukaryotes.
Document type :
Journal articles
Complete list of metadata
Contributor : Charles White Connect in order to contact the contributor
Submitted on : Wednesday, May 25, 2011 - 4:22:57 PM
Last modification on : Tuesday, May 31, 2022 - 10:20:14 AM

Links full text




Maria Eugenia Gallego, Charles I. White. RAD50 function is essential for telomere maintenance in Arabidopsis.. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2001, 98 (4), pp.1711-6. ⟨10.1073/pnas.98.4.1711⟩. ⟨inserm-00595834⟩



Record views