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Homologous recombination in planta is stimulated in the absence of Rad50.

Abstract : Chromosomal double-strand DNA breaks must be repaired; in the absence of repair the resulting acentromeric (and telomereless) fragments may be lost and/or the broken DNA ends may recombine causing general chromosomal instability. The Rad50/Mre11/Xrs2 protein complex acts at DNA ends and is implicated in both homologous and non-homologous recombination. We have isolated a rad50 mutant of the plant Arabidopsis thaliana and show here that it has a somatic hyper-recombination phenotype in planta. This finding supports the hypothesis of a competition between homologous and illegitimate recombination in higher eukaryotes. To our knowledge, this is the first direct in vivo support for the role of this complex in chromosomal recombination in a multicellular organism and the first description of a mutation of a known gene leading to hyper-recombination in plants.
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https://www.hal.inserm.fr/inserm-00595833
Contributor : Charles White <>
Submitted on : Wednesday, May 25, 2011 - 4:22:12 PM
Last modification on : Friday, May 29, 2020 - 4:02:08 PM

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Hassen Gherbi, Maria Eugenia Gallego, Nicole Jalut, Jan Lucht, Barbara Hohn, et al.. Homologous recombination in planta is stimulated in the absence of Rad50.. EMBO Reports, EMBO Press, 2001, 2 (4), pp.287-91. ⟨10.1093/embo-reports/kve069⟩. ⟨inserm-00595833⟩

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