Skip to Main content Skip to Navigation
Journal articles

Homologous recombination in planta is stimulated in the absence of Rad50.

Abstract : Chromosomal double-strand DNA breaks must be repaired; in the absence of repair the resulting acentromeric (and telomereless) fragments may be lost and/or the broken DNA ends may recombine causing general chromosomal instability. The Rad50/Mre11/Xrs2 protein complex acts at DNA ends and is implicated in both homologous and non-homologous recombination. We have isolated a rad50 mutant of the plant Arabidopsis thaliana and show here that it has a somatic hyper-recombination phenotype in planta. This finding supports the hypothesis of a competition between homologous and illegitimate recombination in higher eukaryotes. To our knowledge, this is the first direct in vivo support for the role of this complex in chromosomal recombination in a multicellular organism and the first description of a mutation of a known gene leading to hyper-recombination in plants.
Document type :
Journal articles
Complete list of metadatas
Contributor : Charles White <>
Submitted on : Wednesday, May 25, 2011 - 4:22:12 PM
Last modification on : Tuesday, February 23, 2021 - 11:34:02 AM

Links full text




Hassen Gherbi, Maria Eugenia Gallego, Nicole Jalut, Jan Lucht, Barbara Hohn, et al.. Homologous recombination in planta is stimulated in the absence of Rad50.. EMBO Reports, EMBO Press, 2001, 2 (4), pp.287-91. ⟨10.1093/embo-reports/kve069⟩. ⟨inserm-00595833⟩



Record views