Skip to Main content Skip to Navigation
Journal articles

Deep brain stimulation: from neurology to psychiatry?

Abstract : Functional stereotaxy was introduced in the late 1940s to reduce the morbidity of lobotomy in psychiatric disease by using more focal lesions. The advent of neuroleptics led to a drastic decline in psychosurgery for several decades. Functional stereotactic neurosurgery has recently been revitalized, starting with treatment of Parkinson's disease, in which deep brain stimulation (DBS) facilitates reversible focal neuromodulation of altered basal ganglia circuits. DBS is now being extended to treatment of neuropsychiatric conditions such as Gilles de la Tourette syndrome, obsessive-compulsive disorder, depression and addiction. In this review, we discuss the concept that dysfunction of motor, limbic and associative cortico-basal ganglia-thalamocortical loops underlies these various disorders, which might now be amenable to DBS treatment.
Document type :
Journal articles
Complete list of metadatas

Cited literature [131 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00593713
Contributor : Marc Savasta <>
Submitted on : Thursday, February 2, 2012 - 3:16:51 PM
Last modification on : Thursday, August 27, 2020 - 1:56:03 PM
Long-term archiving on: : Tuesday, December 13, 2016 - 6:57:41 PM

Files

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Paul Krack, Marwan Hariz, Christelle Baunez, Jorge Guridi, Jose Obeso. Deep brain stimulation: from neurology to psychiatry?. Trends in Neurosciences, Elsevier, 2010, 33 (10), pp.474-84. ⟨10.1016/j.tins.2010.07.002⟩. ⟨inserm-00593713⟩

Share

Metrics

Record views

385