Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Astroglial networks scale synaptic activity and plasticity.

Abstract : Astrocytes dynamically interact with neurons to regulate synaptic transmission. Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic physiology is unknown. Here we show, by inactivating Cx30 and Cx43 genes, that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. This regulation limits neuronal excitability, release probability, and insertion of postsynaptic AMPA receptors, silencing synapses. By controlling synaptic strength, connexins play an important role in synaptic plasticity. Altogether, these results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
Document type :
Journal articles
Complete list of metadata
Contributor : Nathalie Rouach Connect in order to contact the contributor
Submitted on : Tuesday, May 10, 2011 - 11:07:24 PM
Last modification on : Tuesday, May 31, 2022 - 10:20:14 AM

Links full text




Ulrike Pannasch, Lydia Vargova, Jurgen Reingruber, Pascal Ezan, David Holcman, et al.. Astroglial networks scale synaptic activity and plasticity.. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, epub ahead of print. ⟨10.1073/pnas.1016650108⟩. ⟨inserm-00592041⟩



Record views