2PremUp Foundation (Fondation de Coopération Scientifique sur la Grossesse et la Prématurité - Maternité de Port Royal - 53 avenue de l'Observatoire - 75014 Paris - France)
Abstract : Excitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits. VIP induces a potent neuroprotection against perinatal excitotoxic white matter damage. VIP does not prevent the initial appearance of white matter lesion but promotes a secondary repair with axonal regrowth. This plasticity mechanism involves an atypical VPAC2 receptor and BDNF production. Stable VIP agonists mimic VIP effects when given systemically and exhibit a large therapeutic window. Unraveling cellular and molecular targets of VIP effects against perinatal white matter lesions could provide a more general rationale to understand the neuroprotection of the developing white matter against excitotoxic insults.
https://www.hal.inserm.fr/inserm-00590464 Contributor : Pierre GressensConnect in order to contact the contributor Submitted on : Thursday, May 3, 2012 - 7:00:17 AM Last modification on : Sunday, June 26, 2022 - 11:53:47 AM Long-term archiving on: : Saturday, August 4, 2012 - 2:20:15 AM