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VIP-induced neuroprotection of the developing brain.

Abstract : Excitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits. VIP induces a potent neuroprotection against perinatal excitotoxic white matter damage. VIP does not prevent the initial appearance of white matter lesion but promotes a secondary repair with axonal regrowth. This plasticity mechanism involves an atypical VPAC2 receptor and BDNF production. Stable VIP agonists mimic VIP effects when given systemically and exhibit a large therapeutic window. Unraveling cellular and molecular targets of VIP effects against perinatal white matter lesions could provide a more general rationale to understand the neuroprotection of the developing white matter against excitotoxic insults.
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Submitted on : Thursday, May 3, 2012 - 7:00:17 AM
Last modification on : Sunday, June 26, 2022 - 11:53:47 AM
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  • HAL Id : inserm-00590464, version 1
  • PUBMED : 21524251


Sandrine Passemard, Paulina Sokolowska, Leslie Schwendimann, Pierre Gressens. VIP-induced neuroprotection of the developing brain.. Current Pharmaceutical Design, Bentham Science Publishers, 2011, 17 (10), pp.1036-9. ⟨inserm-00590464⟩



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