2PremUp Foundation (Fondation de Coopération Scientifique sur la Grossesse et la Prématurité - Maternité de Port Royal - 53 avenue de l'Observatoire - 75014 Paris - France)
Abstract : Excitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits. VIP induces a potent neuroprotection against perinatal excitotoxic white matter damage. VIP does not prevent the initial appearance of white matter lesion but promotes a secondary repair with axonal regrowth. This plasticity mechanism involves an atypical VPAC2 receptor and BDNF production. Stable VIP agonists mimic VIP effects when given systemically and exhibit a large therapeutic window. Unraveling cellular and molecular targets of VIP effects against perinatal white matter lesions could provide a more general rationale to understand the neuroprotection of the developing white matter against excitotoxic insults.
http://www.hal.inserm.fr/inserm-00590464
Contributeur : Pierre Gressens
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Soumis le : jeudi 3 mai 2012 - 07:00:17
Dernière modification le : vendredi 31 août 2018 - 09:00:50
Document(s) archivé(s) le : samedi 4 août 2012 - 02:20:15
