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Journal articles
VIP-induced neuroprotection of the developing brain.
Abstract : Excitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits. VIP induces a potent neuroprotection against perinatal excitotoxic white matter damage. VIP does not prevent the initial appearance of white matter lesion but promotes a secondary repair with axonal regrowth. This plasticity mechanism involves an atypical VPAC2 receptor and BDNF production. Stable VIP agonists mimic VIP effects when given systemically and exhibit a large therapeutic window. Unraveling cellular and molecular targets of VIP effects against perinatal white matter lesions could provide a more general rationale to understand the neuroprotection of the developing white matter against excitotoxic insults.
Cited literature [30 references]
https://www.hal.inserm.fr/inserm-00590464
Contributor : Pierre Gressens Connect in order to contact the contributor
Submitted on : Thursday, May 3, 2012 - 7:00:17 AM
Last modification on : Sunday, June 26, 2022 - 11:53:47 AM
Long-term archiving on: : Saturday, August 4, 2012 - 2:20:15 AM
Contributor : Pierre Gressens Connect in order to contact the contributor
Submitted on : Thursday, May 3, 2012 - 7:00:17 AM
Last modification on : Sunday, June 26, 2022 - 11:53:47 AM
Long-term archiving on: : Saturday, August 4, 2012 - 2:20:15 AM
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