Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Studying network mechanisms using intracranial stimulation in epileptic patients.: Neurostimulation and connectivity in epilepsy

Abstract : Patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axonal tracts in those patients elicits a number of very specific perceptual or behavioral responses, but also abnormal responses due to specific configurations of epileptic networks. Here, we review how anatomo-functional brain connectivity and epilepsy network mechanisms can be assessed from DES responses measured in patients. After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can be used for the characterization of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures. This pool of exceptional data may be underexploited by fundamental research on brain connectivity and leaves much to be learned.
Document type :
Journal articles
Complete list of metadata

Cited literature [117 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00589155
Contributor : Olivier David Connect in order to contact the contributor
Submitted on : Wednesday, April 27, 2011 - 4:12:19 PM
Last modification on : Thursday, May 20, 2021 - 4:50:02 PM
Long-term archiving on: : Thursday, July 28, 2011 - 2:51:35 AM

File

DAVID_2010_Studying_Network_Ed...
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Olivier David, Julien Bastin, Stéphan Chabardès, Lorella Minotti, Philippe Kahane. Studying network mechanisms using intracranial stimulation in epileptic patients.: Neurostimulation and connectivity in epilepsy. Frontiers in Systems Neuroscience, Frontiers, 2010, 4, pp.148. ⟨10.3389/fnsys.2010.00148⟩. ⟨inserm-00589155⟩

Share

Metrics

Record views

111

Files downloads

230