JAK-STAT Signaling: From Interferons to Cytokines, Journal of Biological Chemistry, vol.282, issue.28, pp.20059-20063, 2007. ,
DOI : 10.1074/jbc.R700016200
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis, Oncogene, vol.23, issue.48, pp.8017-8023, 2004. ,
DOI : 10.1038/sj.onc.1208159
Getting the message across, STAT! Design principles of a molecular signaling circuit, The Journal of Cell Biology, vol.15, issue.2, pp.197-201, 2004. ,
DOI : 10.4049/jimmunol.168.9.4567
Transport into and out of the cell nucleus, The EMBO Journal, vol.17, issue.10, pp.2721-2727, 1998. ,
DOI : 10.1093/emboj/17.10.2721
Cao X: A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation, J Biol Chem, issue.31, pp.278-29252, 2003. ,
STAT3 as a central mediator of neoplastic cellular transformation, Cancer Letters, vol.251, issue.2, pp.199-210, 2007. ,
DOI : 10.1016/j.canlet.2006.10.017
Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase, Molecular and Cellular Biology, vol.22, issue.16, pp.22-5662, 2002. ,
DOI : 10.1128/MCB.22.16.5662-5668.2002
Regulation of Stat3 nuclear export, Journal of Clinical Investigation, vol.111, issue.4, pp.553-559, 2003. ,
DOI : 10.1172/JCI15372DS1
Activation of STAT proteins and growth control, BioEssays, vol.9, issue.2, pp.161-169, 2001. ,
DOI : 10.1002/1521-1878(200102)23:2<161::AID-BIES1023>3.0.CO;2-0
Stat proteins and oncogenesis, Journal of Clinical Investigation, vol.109, issue.9, pp.1139-1142, 2002. ,
DOI : 10.1172/JCI0215617
STAT3 as a target for inducing apoptosis in solid and hematological tumors, Cell Research, vol.102, issue.2, pp.254-267, 2008. ,
DOI : 10.1517/14712598.5.8.1085
Stat3 as an Oncogene, Cell, vol.98, issue.3, pp.295-303, 1999. ,
DOI : 10.1016/S0092-8674(00)81959-5
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality, Proceedings of the National Academy of Sciences, vol.94, issue.8, pp.94-3801, 1997. ,
DOI : 10.1073/pnas.94.8.3801
Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3, Cancer Research, vol.65, issue.13, pp.65-5828, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-0317
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins, Cancer Letters, vol.269, issue.2, pp.199-225, 2008. ,
DOI : 10.1016/j.canlet.2008.03.009
Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization, Chemistry & Biology, vol.13, issue.11, pp.1235-1242, 2006. ,
DOI : 10.1016/j.chembiol.2006.09.018
Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide - interference with interferon-??-STAT1-mediated killing, FEBS Journal, vol.270, issue.9, pp.2505-2515, 2009. ,
DOI : 10.1111/j.1742-4658.2009.06975.x
Transcription Factors as Molecular Targets: Molecular Mechanisms of Decoy ODN and their Design, Current Drug Targets, vol.4, issue.8, pp.603-608, 2003. ,
DOI : 10.2174/1389450033490803
Targeting STAT3 in cancer: how successful are we?, Expert Opinion on Investigational Drugs, vol.6, issue.1, pp.45-56, 2009. ,
DOI : 10.1186/1476-4598-4-13
Selective inactivation of NF-??B in the liver using NF-??B decoy suppresses CCl4-induced liver injury and fibrosis, AJP: Gastrointestinal and Liver Physiology, vol.293, issue.3, pp.631-639, 2007. ,
DOI : 10.1152/ajpgi.00185.2007
Cell death in NF-kappaB-dependent tumour cell lines as a result of NF-kappaB trapping by linker-modified hairpin decoy oligonucleotide, FEBS Lett, issue.6, pp.581-1143, 2007. ,
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth, Proceedings of the National Academy of Sciences, vol.100, issue.7, pp.4138-4143, 2003. ,
DOI : 10.1073/pnas.0534764100
Targeting Signal-Transducer-and-Activator-of-Transcription-3 for Prevention and Therapy of Cancer, Annals of the New York Academy of Sciences, vol.3, issue.6, pp.151-169, 2006. ,
DOI : 10.1196/annals.1378.063
Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy- ODN. Cancer Letters, pp.201-213, 2008. ,
In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy, Oncogene, vol.24, issue.6, pp.970-979, 2005. ,
DOI : 10.1038/sj.onc.1208316
DNA Binding Specificity of Different STAT Proteins. COMPARISON OF IN VITRO SPECIFICITY WITH NATURAL TARGET SITES, Journal of Biological Chemistry, vol.276, issue.9, pp.6675-6688, 2001. ,
DOI : 10.1074/jbc.M001748200
Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis, Rheumatology, vol.39, issue.7, pp.39-749, 2000. ,
DOI : 10.1093/rheumatology/39.7.749
Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide: GENE-SPECIFIC INHIBITION OF TUMOR GROWTH, Journal of Biological Chemistry, vol.274, issue.3, pp.1573-1580, 1999. ,
DOI : 10.1074/jbc.274.3.1573
Subcellular localization as a limiting factor for utilization of decoy oligonucleotides, Nucleic Acids Research, vol.32, issue.19, p.142, 2004. ,
DOI : 10.1093/nar/gnh139
Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei, Nucleic Acids Research, vol.33, issue.9, p.88, 2005. ,
DOI : 10.1093/nar/gni088
Nucleocytoplasmic shuttling of persistently activated STAT3, Journal of Cell Science, vol.120, issue.18, pp.3249-3261, 2007. ,
DOI : 10.1242/jcs.03482
STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-??3, Proceedings of the National Academy of Sciences, vol.102, issue.23, pp.8150-8155, 2005. ,
DOI : 10.1073/pnas.0501643102
STAT nuclear translocation: potential for pharmacological intervention, Expert Opinion on Therapeutic Targets, vol.274, issue.10, pp.1355-1365, 2007. ,
DOI : 10.1046/j.1600-6143.2003.00281.x
A signal network involving coactivated NF-??B and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas, International Journal of Cancer, vol.60, issue.9, pp.1987-1998, 2008. ,
DOI : 10.1002/ijc.23324
Dangerous liaisons: STAT3 and NF-??B collaboration and crosstalk in cancer, Cytokine & Growth Factor Reviews, vol.21, issue.1, pp.11-19, 2010. ,
DOI : 10.1016/j.cytogfr.2009.11.005
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain., Genes & Development, vol.9, issue.8, pp.984-994, 1995. ,
DOI : 10.1101/gad.9.8.984
Dusanter-Fourt I, Fagard R: STAT1- dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient, J Leukoc Biol, 2010. ,
Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells, World Journal of Gastroenterology, vol.14, issue.3, pp.428-434, 2008. ,
DOI : 10.3748/wjg.14.428
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter, EMBO J, vol.9, issue.13, pp.4477-4484, 1990. ,
In Vitro and In Vivo Transfection of Melanoma Cells B16-F10 Mediated by Cholesterol-based Cationic Liposomes, Journal of Drug Targeting, vol.10, issue.7, pp.10-557, 2002. ,
DOI : 10.1080/1061186021000038049
Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines, The American Journal of Pathology, vol.167, issue.4, pp.969-980, 2005. ,
DOI : 10.1016/S0002-9440(10)61187-X
Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals, Oncogene, vol.173, issue.13, pp.26-1941, 2007. ,
DOI : 10.1038/sj.onc.1209993
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia, Blood, vol.108, issue.13, pp.4202-4204, 2006. ,
DOI : 10.1182/blood-2006-06-026666
Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines, Int J Mol Med, vol.23, issue.6, pp.805-810, 2009. ,
Loss of STAT1 expression confers resistance to IFN-??-induced apoptosis in ME180 cells, FEBS Letters, vol.75, issue.3, pp.323-326, 1999. ,
DOI : 10.1016/S0014-5793(99)01283-1
STAT1: A Modulator of Chemotherapy-induced Apoptosis, Cancer Research, vol.64, issue.22, pp.8357-8364, 2004. ,
DOI : 10.1158/0008-5472.CAN-04-1864
A Single Residue Modulates Tyrosine Dephosphorylation, Oligomerization, and Nuclear Accumulation of Stat Transcription Factors, Journal of Biological Chemistry, vol.279, issue.18, pp.279-18998, 2004. ,
DOI : 10.1074/jbc.M400766200
Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1, Experimental Cell Research, vol.242, issue.2, pp.540-547, 1998. ,
DOI : 10.1006/excr.1998.4136
IKK/NF-??B and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis, EMBO reports, vol.8, issue.12, pp.1314-1319, 2009. ,
DOI : 10.1038/embor.2009.243
Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein, ChemMedChem, vol.7, issue.8, pp.1159-1168, 2008. ,
DOI : 10.1002/cmdc.200800123
Targeting Stat3 in cancer therapy, Anti-Cancer Drugs, vol.16, issue.6, pp.601-607, 2005. ,
DOI : 10.1097/00001813-200507000-00002
Tracking STAT nuclear traffic, Nature Reviews Immunology, vol.16, issue.8, pp.602-612, 2006. ,
DOI : 10.1038/nri1885
Regulation of Stat3 nuclear import by importin ??5 and importin ??7 via two different functional sequence elements, Cellular Signalling, vol.18, issue.8, pp.1117-1126, 2006. ,
DOI : 10.1016/j.cellsig.2005.06.016
Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin ??5, Journal of Molecular Biology, vol.402, issue.1, pp.83-100, 2010. ,
DOI : 10.1016/j.jmb.2010.07.013
Real Time Analysis of STAT3 Nucleocytoplasmic Shuttling, Journal of Biological Chemistry, vol.279, issue.15, pp.279-15114, 2004. ,
DOI : 10.1074/jbc.M312530200
Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1, The Journal of Cell Biology, vol.15, issue.6, pp.823-833, 2004. ,
DOI : 10.4049/jimmunol.168.9.4567
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF??B, Genes & Development, vol.21, issue.11, pp.1396-1408, 2007. ,
DOI : 10.1101/gad.1553707
Roles of unphosphorylated STATs in signaling, Cell Research, vol.12, issue.4, pp.443-451, 2008. ,
DOI : 10.1016/S1534-5807(02)00126-0
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases, Science, issue.5343, pp.278-1630, 1997. ,
STAT1 and pathogens, not a friendly relationship, Biochimie, vol.92, issue.5, pp.425-444, 2010. ,
DOI : 10.1016/j.biochi.2010.02.009
STATs as activators of apoptosis, Trends in Cell Biology, vol.8, issue.3, pp.97-98, 1998. ,
DOI : 10.1016/S0962-8924(98)01233-1
The Anti-proliferative Activity of Interferon-?? on Ovarian Cancer: In Vitro and in Vivo, Gynecologic Oncology, vol.88, issue.1, pp.149-151, 2003. ,
DOI : 10.1006/gyno.2002.6707
Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway, J Endocrinol, issue.2, pp.199-177, 2008. ,
Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity, Journal of Allergy and Clinical Immunology, vol.121, issue.1, pp.158-165, 2008. ,
DOI : 10.1016/j.jaci.2007.09.015
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma., Proceedings of the National Academy of Sciences, vol.93, issue.15, pp.93-7673, 1996. ,
DOI : 10.1073/pnas.93.15.7673
Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling, Seminars in Cell & Developmental Biology, vol.19, issue.4, 2008. ,
DOI : 10.1016/j.semcdb.2008.06.004
Lack of toxicity of a STAT3 decoy oligonucleotide, Cancer Chemotherapy and Pharmacology, vol.7, issue.6, pp.63-983, 2009. ,
DOI : 10.1007/s00280-008-0823-6
Persistently Activated Stat3 Maintains Constitutive NF-??B Activity in Tumors, Cancer Cell, vol.15, issue.4, pp.283-293, 2009. ,
DOI : 10.1016/j.ccr.2009.02.015