C. Schindler, D. Levy, and T. Decker, JAK-STAT Signaling: From Interferons to Cytokines, Journal of Biological Chemistry, vol.282, issue.28, pp.20059-20063, 2007.
DOI : 10.1074/jbc.R700016200

C. Silva, Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis, Oncogene, vol.23, issue.48, pp.8017-8023, 2004.
DOI : 10.1038/sj.onc.1208159

U. Vinkemeier, Getting the message across, STAT! Design principles of a molecular signaling circuit, The Journal of Cell Biology, vol.15, issue.2, pp.197-201, 2004.
DOI : 10.4049/jimmunol.168.9.4567

D. Gorlich, Transport into and out of the cell nucleus, The EMBO Journal, vol.17, issue.10, pp.2721-2727, 1998.
DOI : 10.1093/emboj/17.10.2721

J. Ma, T. Zhang, V. Novotny-diermayr, and A. Tan, Cao X: A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation, J Biol Chem, issue.31, pp.278-29252, 2003.

D. Frank, STAT3 as a central mediator of neoplastic cellular transformation, Cancer Letters, vol.251, issue.2, pp.199-210, 2007.
DOI : 10.1016/j.canlet.2006.10.017

J. Ten-hoeve, J. De, M. Ibarra-sanchez, Y. Fu, W. Zhu et al., Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase, Molecular and Cellular Biology, vol.22, issue.16, pp.22-5662, 2002.
DOI : 10.1128/MCB.22.16.5662-5668.2002

S. Bhattacharya and C. Schindler, Regulation of Stat3 nuclear export, Journal of Clinical Investigation, vol.111, issue.4, pp.553-559, 2003.
DOI : 10.1172/JCI15372DS1

J. Bromberg, Activation of STAT proteins and growth control, BioEssays, vol.9, issue.2, pp.161-169, 2001.
DOI : 10.1002/1521-1878(200102)23:2<161::AID-BIES1023>3.0.CO;2-0

J. Bromberg, Stat proteins and oncogenesis, Journal of Clinical Investigation, vol.109, issue.9, pp.1139-1142, 2002.
DOI : 10.1172/JCI0215617

A. Zaid-siddiquee, K. Turkson, and J. , STAT3 as a target for inducing apoptosis in solid and hematological tumors, Cell Research, vol.102, issue.2, pp.254-267, 2008.
DOI : 10.1517/14712598.5.8.1085

J. Bromberg, M. Wrzeszczynska, G. Devgan, Y. Zhao, R. Pestell et al., Stat3 as an Oncogene, Cell, vol.98, issue.3, pp.295-303, 1999.
DOI : 10.1016/S0092-8674(00)81959-5

K. Takeda, K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto et al., Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality, Proceedings of the National Academy of Sciences, vol.94, issue.8, pp.94-3801, 1997.
DOI : 10.1073/pnas.94.8.3801

K. Schlessinger and D. Levy, Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3, Cancer Research, vol.65, issue.13, pp.65-5828, 2005.
DOI : 10.1158/0008-5472.CAN-05-0317

A. Kunnumakkara, P. Anand, and B. Aggarwal, Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins, Cancer Letters, vol.269, issue.2, pp.199-225, 2008.
DOI : 10.1016/j.canlet.2008.03.009

J. Schust, B. Sperl, A. Hollis, T. Mayer, and T. Berg, Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization, Chemistry & Biology, vol.13, issue.11, pp.1235-1242, 2006.
DOI : 10.1016/j.chembiol.2006.09.018

T. Hbibi, A. Laguillier, C. Souissi, I. Lesage, D. et al., Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide - interference with interferon-??-STAT1-mediated killing, FEBS Journal, vol.270, issue.9, pp.2505-2515, 2009.
DOI : 10.1111/j.1742-4658.2009.06975.x

N. Tomita, T. Ogihara, and R. Morishita, Transcription Factors as Molecular Targets: Molecular Mechanisms of Decoy ODN and their Design, Current Drug Targets, vol.4, issue.8, pp.603-608, 2003.
DOI : 10.2174/1389450033490803

P. Yue and J. Turkson, Targeting STAT3 in cancer: how successful are we?, Expert Opinion on Investigational Drugs, vol.6, issue.1, pp.45-56, 2009.
DOI : 10.1186/1476-4598-4-13

G. Son, Y. Iimuro, E. Seki, T. Hirano, Y. Kaneda et al., Selective inactivation of NF-??B in the liver using NF-??B decoy suppresses CCl4-induced liver injury and fibrosis, AJP: Gastrointestinal and Liver Physiology, vol.293, issue.3, pp.631-639, 2007.
DOI : 10.1152/ajpgi.00185.2007

C. Laguillier, A. Hbibi, F. Baran-marszak, V. Metelev, A. Cao et al., Cell death in NF-kappaB-dependent tumour cell lines as a result of NF-kappaB trapping by linker-modified hairpin decoy oligonucleotide, FEBS Lett, issue.6, pp.581-1143, 2007.

P. Leong, G. Andrews, D. Johnson, K. Dyer, S. Xi et al., Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth, Proceedings of the National Academy of Sciences, vol.100, issue.7, pp.4138-4143, 2003.
DOI : 10.1073/pnas.0534764100

B. Aggarwal, G. Sethi, K. Ahn, S. Sandur, M. Pandey et al., Targeting Signal-Transducer-and-Activator-of-Transcription-3 for Prevention and Therapy of Cancer, Annals of the New York Academy of Sciences, vol.3, issue.6, pp.151-169, 2006.
DOI : 10.1196/annals.1378.063

X. Sun, J. Zhang, L. Wang, and Z. Tian, Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy- ODN. Cancer Letters, pp.201-213, 2008.

S. Xi, W. Gooding, and J. Grandis, In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy, Oncogene, vol.24, issue.6, pp.970-979, 2005.
DOI : 10.1038/sj.onc.1208316

G. Ehret, P. Reichenbach, U. Schindler, C. Horvath, S. Fritz et al., DNA Binding Specificity of Different STAT Proteins. COMPARISON OF IN VITRO SPECIFICITY WITH NATURAL TARGET SITES, Journal of Biological Chemistry, vol.276, issue.9, pp.6675-6688, 2001.
DOI : 10.1074/jbc.M001748200

T. Tomita, H. Takano, N. Tomita, R. Morishita, M. Kaneko et al., Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis, Rheumatology, vol.39, issue.7, pp.39-749, 2000.
DOI : 10.1093/rheumatology/39.7.749

Y. Park, M. Nesterova, S. Agrawal, and Y. Cho-chung, Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide: GENE-SPECIFIC INHIBITION OF TUMOR GROWTH, Journal of Biological Chemistry, vol.274, issue.3, pp.1573-1580, 1999.
DOI : 10.1074/jbc.274.3.1573

A. Bene, R. Kurten, and T. Chambers, Subcellular localization as a limiting factor for utilization of decoy oligonucleotides, Nucleic Acids Research, vol.32, issue.19, p.142, 2004.
DOI : 10.1093/nar/gnh139

M. Sakaguchi, T. Nukui, H. Sonegawa, H. Murata, J. Futami et al., Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei, Nucleic Acids Research, vol.33, issue.9, p.88, 2005.
DOI : 10.1093/nar/gni088

A. Herrmann, M. Vogt, M. Monnigmann, T. Clahsen, U. Sommer et al., Nucleocytoplasmic shuttling of persistently activated STAT3, Journal of Cell Science, vol.120, issue.18, pp.3249-3261, 2007.
DOI : 10.1242/jcs.03482

L. Liu, K. Mcbride, and N. Reich, STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-??3, Proceedings of the National Academy of Sciences, vol.102, issue.23, pp.8150-8155, 2005.
DOI : 10.1073/pnas.0501643102

T. Meyer and U. Vinkemeier, STAT nuclear translocation: potential for pharmacological intervention, Expert Opinion on Therapeutic Targets, vol.274, issue.10, pp.1355-1365, 2007.
DOI : 10.1046/j.1600-6143.2003.00281.x

T. Lee, J. Yeh, J. Friedman, Y. B. Yang, X. Yeh et al., A signal network involving coactivated NF-??B and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas, International Journal of Cancer, vol.60, issue.9, pp.1987-1998, 2008.
DOI : 10.1002/ijc.23324

S. Grivennikov and K. M. , Dangerous liaisons: STAT3 and NF-??B collaboration and crosstalk in cancer, Cytokine & Growth Factor Reviews, vol.21, issue.1, pp.11-19, 2010.
DOI : 10.1016/j.cytogfr.2009.11.005

C. Horvath, Z. Wen, and J. Darnell, A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain., Genes & Development, vol.9, issue.8, pp.984-994, 1995.
DOI : 10.1101/gad.9.8.984

I. Najjar, P. Deglesne, P. Schischmanoff, E. Fabre, S. Boisson-dupuis et al., Dusanter-Fourt I, Fagard R: STAT1- dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient, J Leukoc Biol, 2010.

Y. Fan, Y. Zhang, Y. Wu, W. Zhang, Y. Wang et al., Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells, World Journal of Gastroenterology, vol.14, issue.3, pp.428-434, 2008.
DOI : 10.3748/wjg.14.428

B. Wagner, T. Hayes, C. Hoban, and B. Cochran, The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter, EMBO J, vol.9, issue.13, pp.4477-4484, 1990.

P. Reynier, D. Briane, A. Cao, N. Lievre, R. Naejus et al., In Vitro and In Vivo Transfection of Melanoma Cells B16-F10 Mediated by Cholesterol-based Cationic Liposomes, Journal of Drug Targeting, vol.10, issue.7, pp.10-557, 2002.
DOI : 10.1080/1061186021000038049

Q. Lin, R. Lai, L. Chirieac, C. Li, V. Thomazy et al., Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines, The American Journal of Pathology, vol.167, issue.4, pp.969-980, 2005.
DOI : 10.1016/S0002-9440(10)61187-X

M. Evans, C. Yu, A. Lohani, R. Mahdi, X. Liu et al., Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals, Oncogene, vol.173, issue.13, pp.26-1941, 2007.
DOI : 10.1038/sj.onc.1209993

T. Gu, V. Goss, C. Reeves, L. Popova, J. Nardone et al., Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia, Blood, vol.108, issue.13, pp.4202-4204, 2006.
DOI : 10.1182/blood-2006-06-026666

S. Shim, M. Sung, S. Park, and D. Heo, Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines, Int J Mol Med, vol.23, issue.6, pp.805-810, 2009.

K. Lee, E. Anderson, K. Madani, and G. Rosen, Loss of STAT1 expression confers resistance to IFN-??-induced apoptosis in ME180 cells, FEBS Letters, vol.75, issue.3, pp.323-326, 1999.
DOI : 10.1016/S0014-5793(99)01283-1

M. Thomas, C. Finnegan, K. Rogers, J. Purcell, A. Trimble et al., STAT1: A Modulator of Chemotherapy-induced Apoptosis, Cancer Research, vol.64, issue.22, pp.8357-8364, 2004.
DOI : 10.1158/0008-5472.CAN-04-1864

T. Meyer, L. Hendry, A. Begitt, S. John, and U. Vinkemeier, A Single Residue Modulates Tyrosine Dephosphorylation, Oligomerization, and Nuclear Accumulation of Stat Transcription Factors, Journal of Biological Chemistry, vol.279, issue.18, pp.279-18998, 2004.
DOI : 10.1074/jbc.M400766200

N. Kudo, B. Wolff, T. Sekimoto, E. Schreiner, Y. Yoneda et al., Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1, Experimental Cell Research, vol.242, issue.2, pp.540-547, 1998.
DOI : 10.1006/excr.1998.4136

J. Bollrath and F. Greten, IKK/NF-??B and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis, EMBO reports, vol.8, issue.12, pp.1314-1319, 2009.
DOI : 10.1038/embor.2009.243

S. Fletcher, J. Turkson, and P. Gunning, Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein, ChemMedChem, vol.7, issue.8, pp.1159-1168, 2008.
DOI : 10.1002/cmdc.200800123

N. Jing and D. Tweardy, Targeting Stat3 in cancer therapy, Anti-Cancer Drugs, vol.16, issue.6, pp.601-607, 2005.
DOI : 10.1097/00001813-200507000-00002

N. Reich and L. Liu, Tracking STAT nuclear traffic, Nature Reviews Immunology, vol.16, issue.8, pp.602-612, 2006.
DOI : 10.1038/nri1885

J. Ma and X. Cao, Regulation of Stat3 nuclear import by importin ??5 and importin ??7 via two different functional sequence elements, Cellular Signalling, vol.18, issue.8, pp.1117-1126, 2006.
DOI : 10.1016/j.cellsig.2005.06.016

J. Nardozzi, N. Wenta, N. Yasuhara, U. Vinkemeier, and G. Cingolani, Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin ??5, Journal of Molecular Biology, vol.402, issue.1, pp.83-100, 2010.
DOI : 10.1016/j.jmb.2010.07.013

A. Pranada, S. Metz, A. Herrmann, P. Heinrich, and G. Muller-newen, Real Time Analysis of STAT3 Nucleocytoplasmic Shuttling, Journal of Biological Chemistry, vol.279, issue.15, pp.279-15114, 2004.
DOI : 10.1074/jbc.M312530200

A. Marg, Y. Shan, T. Meyer, T. Meissner, M. Brandenburg et al., Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1, The Journal of Cell Biology, vol.15, issue.6, pp.823-833, 2004.
DOI : 10.4049/jimmunol.168.9.4567

J. Yang, X. Liao, M. Agarwal, L. Barnes, P. Auron et al., Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF??B, Genes & Development, vol.21, issue.11, pp.1396-1408, 2007.
DOI : 10.1101/gad.1553707

J. Yang and G. Stark, Roles of unphosphorylated STATs in signaling, Cell Research, vol.12, issue.4, pp.443-451, 2008.
DOI : 10.1016/S1534-5807(02)00126-0

A. Kumar, M. Commane, T. Flickinger, C. Horvath, and G. Stark, Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases, Science, issue.5343, pp.278-1630, 1997.

I. Najjar and R. Fagard, STAT1 and pathogens, not a friendly relationship, Biochimie, vol.92, issue.5, pp.425-444, 2010.
DOI : 10.1016/j.biochi.2010.02.009

C. Schindler, STATs as activators of apoptosis, Trends in Cell Biology, vol.8, issue.3, pp.97-98, 1998.
DOI : 10.1016/S0962-8924(98)01233-1

L. Wall, F. Burke, J. Smyth, and F. Balkwill, The Anti-proliferative Activity of Interferon-?? on Ovarian Cancer: In Vitro and in Vivo, Gynecologic Oncology, vol.88, issue.1, pp.149-151, 2003.
DOI : 10.1006/gyno.2002.6707

M. Labeur, D. Refojo, B. Wolfel, J. Stalla, V. Vargas et al., Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway, J Endocrinol, issue.2, pp.199-177, 2008.

A. Wagner, I. Wittjen, T. Stojanovic, P. Middel, J. Meingassner et al., Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity, Journal of Allergy and Clinical Immunology, vol.121, issue.1, pp.158-165, 2008.
DOI : 10.1016/j.jaci.2007.09.015

J. Bromberg, C. Horvath, Z. Wen, R. Schreiber, and J. Darnell, Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma., Proceedings of the National Academy of Sciences, vol.93, issue.15, pp.93-7673, 1996.
DOI : 10.1073/pnas.93.15.7673

G. Regis, S. Pensa, D. Boselli, F. Novelli, and V. Poli, Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling, Seminars in Cell & Developmental Biology, vol.19, issue.4, 2008.
DOI : 10.1016/j.semcdb.2008.06.004

M. Sen, P. Tosca, C. Zwayer, M. Ryan, J. Johnson et al., Lack of toxicity of a STAT3 decoy oligonucleotide, Cancer Chemotherapy and Pharmacology, vol.7, issue.6, pp.63-983, 2009.
DOI : 10.1007/s00280-008-0823-6

H. Lee, A. Herrmann, J. Deng, M. Kujawski, G. Niu et al., Persistently Activated Stat3 Maintains Constitutive NF-??B Activity in Tumors, Cancer Cell, vol.15, issue.4, pp.283-293, 2009.
DOI : 10.1016/j.ccr.2009.02.015