Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study.: Metabolic Syndrome and depression in elderly

Tasnime Akbaraly 1, 2, * Marie-Laure Ancelin 1 Isabelle Jaussent 1 Craig Ritchie 3 Pascale Barberger-Gateau 4 Carole Dufouil 5 Mika Kivimaki 2 Claudine Berr 1, 6 Karen Ritchie 1, 3
* Auteur correspondant
1 Pathologies du système nerveux : recherche épidémiologique et clinique
2 Department of Epidemiology and Public Health
3 Neuroscience Division
4 Epidémiologie et Biostatistique [Bordeaux]
5 Neuroépidémiologie
6 CMRR - Centres Mémoire de Ressources et de Recherche Montpellier
Abstract : OBJECTIVE Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age-groups in a large, general elderly population. RESEARCH DESIGN AND METHODS This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups. RESULTS After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02-2.95) odds for new-onset depressive symptoms in the youngest age-group (65-70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age-groups. CONCLUSIONS Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65-70 years.
Keywords : Depressive symptoms metabolic syndrome elderly prospective study
Type de document :
Article dans une revue
Diabetes Care, American Diabetes Association, 2011, 34 (4), pp.904-9. 〈10.2337/dc10-1644〉
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Tasnime Akbaraly, Marie-Laure Ancelin, Isabelle Jaussent, Craig Ritchie, Pascale Barberger-Gateau, et al.. Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study.: Metabolic Syndrome and depression in elderly. Diabetes Care, American Diabetes Association, 2011, 34 (4), pp.904-9. 〈10.2337/dc10-1644〉. 〈inserm-00588145〉

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