Intérêt de la MGMT dans les gliomes. [MGMT analysis in gliomas].

Véronique Quillien 1, 2, * Elodie Vauléon 1, 2 Stephan Saikali 3 Thierry Lesimple 4 Abderrahmane Hamlat 3 Amandine Etcheverry 2, 5 Jean Mosser 2, 5, 6
* Auteur correspondant
1 Service de Biologie
2 IGDR - Institut de Génétique et Développement de Rennes
3 Service d'anatomie et cytologie pathologiques [Rennes]
4 Département d'oncologie médicale [Rennes]
5 Plate-forme transcriptome
6 Service de Génétique Moléculaire et Génomique
Abstract : MGMT status is now regarded as a strong predictive factor of response to standard treatment of newly diagnosed glioblastomas involving temozolomide (TMZ) and radiotherapy. MGMT promoter methylation is also a prognostic factor - independent of treatment - in anaplastic gliomas. The predictive function can be explained by the role of the DNA repair enzyme MGMT, which antagonizes the effects of alkylating agents such as TMZ. MGMT promoter methylation could also reflect a particular molecular phenotype with its own specific prognostic significance. Since MGMT status determination is becoming a crucial biological marker in new clinical glioma trials, and is beginning to be used in day-to-day clinical practice, there is currently a strong need to determine the best technique for MGMT analysis. A French multicenter study has been set up for this purpose.
Keywords : MGMT gliomas prognostic factor predictive factor
Type de document :
Article dans une revue
Bulletin du Cancer, John Libbey Eurotext, 2011, 98 (3), pp.291-303. 〈10.1684/bdc.2011.1332〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00587564
Contributeur : Hervé De Villemeur <>
Soumis le : mercredi 20 avril 2011 - 17:42:19
Dernière modification le : mercredi 16 mai 2018 - 11:23:34

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IGDR | BIOSIT | UR1-UFR-SVE | MARQUIS | FNCLCC | UNIV-RENNES

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Véronique Quillien, Elodie Vauléon, Stephan Saikali, Thierry Lesimple, Abderrahmane Hamlat, et al.. Intérêt de la MGMT dans les gliomes. [MGMT analysis in gliomas].. Bulletin du Cancer, John Libbey Eurotext, 2011, 98 (3), pp.291-303. 〈10.1684/bdc.2011.1332〉. 〈inserm-00587564〉

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