Control of neuronal network organization by chemical surface functionalization of multi-walled carbon nanotube arrays.

Carbon nanotube substrates are promising candidates for biological applications and devices. Interfacing of these carbon nanotubes with neurons can be controlled by chemical modifications. In this study, we investigated how chemical surface functionalization of multi-walled carbon nanotube arrays (MWNT-A) influences neuronal adhesion and network organization. Functionalization of MWNT-A dramatically modifies the length of neurite fascicles, cluster inter-connection success rate, and the percentage of neurites that escape from the clusters. We propose that chemical functionalization represents a method of choice for developing applications in which neuronal patterning on MWNT-A substrates is required.

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Neurosciences [q-bio.NC]

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inserm-00587525_edited.pdf (909.07 Ko)

Liu-2011-Control-SD-FIG_Auteur.pdf (365.91 Ko)

Liu-2011-Control_Auteur.pdf (1.41 Mo)

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https://inserm.hal.science/inserm-00587525

Soumis le : mercredi 20 avril 2011-15:46:46

Dernière modification le : jeudi 4 avril 2024-21:00:37

Archivage à long terme le : jeudi 21 juillet 2011-03:10:08

Dates et versions

inserm-00587525 , version 1 (20-04-2011)

Identifiants

HAL Id : inserm-00587525 , version 1
DOI : 10.1088/0957-4484/22/19/195101
PUBMED : 21436508

Citer

Jie Liu, Florence Appaix, Olivier Bibari, Gilles Marchand, Alim-Louis Benabid, et al.. Control of neuronal network organization by chemical surface functionalization of multi-walled carbon nanotube arrays.. Nanotechnology, 2011, 22 (19), pp.195101. ⟨10.1088/0957-4484/22/19/195101⟩. ⟨inserm-00587525⟩

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