A. Aguzzi and L. Rajendran, The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids, Neuron, vol.64, issue.6, pp.783-790, 2009.
DOI : 10.1016/j.neuron.2009.12.016

R. M. Arantes and N. W. Andrews, A Role for Synaptotagmin VII-Regulated Exocytosis of Lysosomes in Neurite Outgrowth from Primary Sympathetic Neurons, Journal of Neuroscience, vol.26, issue.17, pp.4630-4637, 2006.
DOI : 10.1523/JNEUROSCI.0009-06.2006

M. Belting and A. Wittrup, Nanotubes, exosomes, and nucleic acid???binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease, The Journal of Cell Biology, vol.95, issue.7, pp.1187-1191, 2008.
DOI : 10.1038/nbt1339

F. Bianco, C. Perrotta, L. Novellino, M. Francolini, L. Riganti et al., Acid sphingomyelinase activity triggers microparticle release from glial cells, The EMBO Journal, vol.170, issue.8, pp.1043-1054, 2009.
DOI : 10.1006/exnr.1997.6723

F. Bianco, E. Pravettoni, A. Colombo, U. Schenk, T. Moller et al., Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1?? Release from Microglia, The Journal of Immunology, vol.174, issue.11, pp.7268-7277, 2005.
DOI : 10.4049/jimmunol.174.11.7268

T. Bordet, L. Castelnau-ptakhine, F. Fauchereau, G. Friocourt, A. Kahn et al., Neuronal Targeting of Cardiotrophin-1 by Coupling with Tetanus Toxin C Fragment, Molecular and Cellular Neuroscience, vol.17, issue.5, pp.842-854, 2001.
DOI : 10.1006/mcne.2001.0979

B. Borgonovo, E. Cocucci, G. Racchetti, P. Podini, A. Bachi et al., Regulated exocytosis: a novel, widely expressed system, Nature Cell Biology, vol.4, issue.12, pp.955-962, 2002.
DOI : 10.1038/ncb888

C. Chatellard-causse, B. Blot, N. Cristina, S. Torch, M. Missotten et al., Alix (ALG-2-interacting Protein X), a Protein Involved in Apoptosis, Binds to Endophilins and Induces Cytoplasmic Vacuolization, Journal of Biological Chemistry, vol.277, issue.32, pp.29108-29115, 2002.
DOI : 10.1074/jbc.M204019200

M. Chiappalone, M. Bove, A. Vato, M. Tedesco, and S. Martinoia, Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development, Brain Research, vol.1093, issue.1, pp.41-53, 2006.
DOI : 10.1016/j.brainres.2006.03.049

J. R. Cooney, J. L. Hurlburt, D. K. Selig, K. M. Harris, and J. C. Fiala, Endosomal Compartments Serve Multiple Hippocampal Dendritic Spines from a Widespread Rather Than a Local Store of Recycling Membrane, J. Neurosci, vol.22, pp.2215-2224, 2002.

M. Cordero-erausquin, S. Allard, T. Dolique, K. Bachand, A. Ribeiro-da-silva et al., Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling, The Journal of Comparative Neurology, vol.69, issue.4, pp.601-615, 2009.
DOI : 10.1002/cne.22179

K. Deinhardt, O. Berninghausen, H. J. Willison, C. R. Hopkins, and G. Schiavo, Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1, The Journal of Cell Biology, vol.114, issue.3, pp.459-471, 2006.
DOI : 10.1016/S0014-5793(97)01328-8

C. M. Fader, D. Sanchez, M. Furlan, and M. I. Colombo, Induction of Autophagy Promotes Fusion of Multivesicular Bodies with Autophagic Vacuoles in K562 Cells, Traffic, vol.171, issue.2, pp.230-250, 2008.
DOI : 10.1111/j.1600-0854.2007.00677.x

J. Faure, G. Lachenal, M. Court, J. Hirrlinger, C. Chatellard-causse et al., Exosomes are released by cultured cortical neurones, Molecular and Cellular Neuroscience, vol.31, issue.4, pp.642-648, 2006.
DOI : 10.1016/j.mcn.2005.12.003

URL : https://hal.archives-ouvertes.fr/inserm-00393925

B. Fevrier, D. Vilette, H. Laude, and G. Raposo, Exosomes: a bubble ride for prions? Traffic, pp.10-17, 2005.

J. W. Francis, E. Bastia, C. C. Matthews, D. A. Parks, M. A. Schwarzschild et al., Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNS, Brain Research, vol.1011, issue.1, pp.7-13, 2004.
DOI : 10.1016/j.brainres.2004.03.007

C. E. Futter, A. Pearse, L. J. Hewlett, and C. R. Hopkins, Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes, The Journal of Cell Biology, vol.132, issue.6, pp.1011-1023, 1996.
DOI : 10.1083/jcb.132.6.1011

S. H. Gerber and T. C. Sudhof, Molecular Determinants of Regulated Exocytosis, Diabetes, vol.51, issue.Supplement 1, pp.3-11, 2002.
DOI : 10.2337/diabetes.51.2007.S3

R. Ghidoni, A. Paterlini, V. Albertini, M. Glionna, E. Monti et al., Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease, Neurobiology of Aging, vol.32, issue.8, 2009.
DOI : 10.1016/j.neurobiolaging.2009.08.013

C. Grumelli, C. Verderio, D. Pozzi, O. Rossetto, C. Montecucco et al., Internalization and Mechanism of Action of Clostridial Toxins in Neurons, NeuroToxicology, vol.26, issue.5, pp.761-767, 2005.
DOI : 10.1016/j.neuro.2004.12.012

J. Herreros, T. Ng, and G. Schiavo, Lipid Rafts Act as Specialized Domains for Tetanus Toxin Binding and Internalization into Neurons, Molecular Biology of the Cell, vol.12, issue.10, pp.2947-2960, 2001.
DOI : 10.1091/mbc.12.10.2947

M. J. Kennedy and M. D. Ehlers, ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY, Annual Review of Neuroscience, vol.29, issue.1, pp.325-362, 2006.
DOI : 10.1146/annurev.neuro.29.051605.112808

C. Korkut, B. Ataman, P. Ramachandran, J. Ashley, R. Barria et al., Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless, Cell, vol.139, issue.2, pp.393-404, 2009.
DOI : 10.1016/j.cell.2009.07.051

E. M. Krämer-albers, N. Bretz, S. Tenzer, C. Winterstein, W. Möbius et al., Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?, PROTEOMICS ??? CLINICAL APPLICATIONS, vol.23, issue.11, pp.1446-1461, 2007.
DOI : 10.1002/prca.200700522

G. Lalli, S. Bohnert, K. Deinhardt, C. Verastegui, and G. Schiavo, The journey of tetanus and botulinum neurotoxins in neurons, Trends in Microbiology, vol.11, issue.9, pp.431-437, 2003.
DOI : 10.1016/S0966-842X(03)00210-5

P. F. Maness and M. Schachner, Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration, Nature Neuroscience, vol.22, issue.1, pp.19-26, 2007.
DOI : 10.1126/science.1093923

A. M. Marzesco, P. Janich, M. Wilsch-brauninger, V. Dubreuil, K. Langenfeld et al., Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells, Journal of Cell Science, vol.118, issue.13, pp.2849-2858, 2005.
DOI : 10.1242/jcs.02439

U. Maskos, K. Kissa, C. St-cloment, and P. Brulet, Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice, Proceedings of the National Academy of Sciences, vol.99, issue.15, pp.10120-10125, 2002.
DOI : 10.1073/pnas.152266799

S. Mathivanan and R. J. Simpson, ExoCarta: A compendium of exosomal proteins and RNA, PROTEOMICS, vol.36, issue.21, pp.4997-5000, 2009.
DOI : 10.1002/pmic.200900351

F. J. Miana-mena, S. Roux, J. C. Benichou, R. Osta, and P. Brulet, Neuronal activity-dependent membrane traffic at the neuromuscular junction, Proceedings of the National Academy of Sciences, vol.99, issue.5, pp.3234-3239, 2002.
DOI : 10.1073/pnas.052023599

A. E. Morelli, A. T. Larregina, W. J. Shufesky, M. L. Sullivan, D. B. Stolz et al., Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells, Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells, pp.3257-3266, 2004.
DOI : 10.1182/blood-2004-03-0824

T. M. Newpher and M. D. Ehlers, Glutamate Receptor Dynamics in Dendritic Microdomains, Neuron, vol.58, issue.4, pp.472-497, 2008.
DOI : 10.1016/j.neuron.2008.04.030

M. Ostrowski, N. B. Carmo, S. Krumeich, I. Fanget, G. Raposo et al., Rab27a and Rab27b control different steps of the exosome secretion pathway, Nature Cell Biology, vol.114, issue.1, pp.19-30, 2010.
DOI : 10.1016/S0006-3495(99)77382-0

B. T. Pan, K. Teng, C. Wu, M. Adam, and R. M. Johnstone, Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes, The Journal of Cell Biology, vol.101, issue.3, pp.942-948, 1985.
DOI : 10.1083/jcb.101.3.942

V. I. Popov, N. I. Medvedev, I. V. Kraev, P. L. Gabbott, H. A. Davies et al., A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study, European Journal of Neuroscience, vol.40, issue.2, pp.301-314, 2008.
DOI : 10.1111/j.1460-9568.2007.06004.x

I. Potolicchio, G. J. Carven, X. Xu, C. Stipp, R. J. Riese et al., Proteomic Analysis of Microglia-Derived Exosomes: Metabolic Role of the Aminopeptidase CD13 in Neuropeptide Catabolism, The Journal of Immunology, vol.175, issue.4, pp.2237-2243, 2005.
DOI : 10.4049/jimmunol.175.4.2237

U. Putz, J. Howitt, J. Lackovic, N. Foot, S. Kumar et al., Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins, Journal of Biological Chemistry, vol.283, issue.47, pp.32621-32627, 2008.
DOI : 10.1074/jbc.M804120200

Y. Qu, L. Franchi, G. Nunez, and G. R. Dubyak, Nonclassical IL-1?? Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages, The Journal of Immunology, vol.179, issue.3, pp.1913-1925, 2007.
DOI : 10.4049/jimmunol.179.3.1913

Y. Qu, L. Ramachandra, S. Mohr, L. Franchi, C. V. Harding et al., P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1, The Journal of Immunology, vol.182, issue.8, 2009.
DOI : 10.4049/jimmunol.0802968

H. B. Rind, R. Butowt, and C. S. Von-bartheld, Synaptic Targeting of Retrogradely Transported Trophic Factors in Motoneurons: Comparison of Glial Cell Line-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor, and Cardiotrophin-1 with Tetanus Toxin, Journal of Neuroscience, vol.25, issue.3, pp.539-549, 2005.
DOI : 10.1523/JNEUROSCI.4322-04.2005

A. Savina, C. M. Fader, M. T. Damiani, and M. I. Colombo, Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium-Dependent Manner, Traffic, vol.5, issue.16, pp.131-143, 2005.
DOI : 10.1111/j.1600-0854.2004.00257.x

M. Simons and G. Raposo, Exosomes ??? vesicular carriers for intercellular communication, Current Opinion in Cell Biology, vol.21, issue.4, 2009.
DOI : 10.1016/j.ceb.2009.03.007

J. Skog, T. Wurdinger, S. Van-rijn, D. H. Meijer, L. Gainche et al., Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nature Cell Biology, vol.94, issue.12, pp.1470-1476, 2008.
DOI : 10.1371/journal.pone.0000571

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423894

N. R. Smalheiser, Exosomal transfer of proteins and RNAs at synapses in the nervous system, Biology Direct, vol.2, issue.1, p.35, 2007.
DOI : 10.1186/1745-6150-2-35

A. R. Taylor, M. B. Robinson, D. J. Gifondorwa, M. Tytell, and C. E. Milligan, Regulation of heat shock protein 70 release in astrocytes: Role of signaling kinases, Developmental Neurobiology, vol.278, issue.13, pp.1815-1829, 2007.
DOI : 10.1002/dneu.20559

C. Thery, L. Duban, E. Segura, P. Veron, O. Lantz et al., Indirect activation of na??ve CD4+ T cells by dendritic cell???derived exosomes, Nature Immunology, vol.3, issue.12, pp.1156-1162, 2002.
DOI : 10.1038/ni854

C. Thery, M. Ostrowski, and E. Segura, Membrane vesicles as conveyors of immune responses, Nature Reviews Immunology, vol.166, issue.8, pp.581-593, 2009.
DOI : 10.1038/nri2567

K. T. Tokuyasu, Application of cryoultramicrotomy to immunocytochemistry, Journal of Microscopy, vol.71, issue.2, pp.139-149, 1986.
DOI : 10.1111/j.1365-2818.1986.tb02772.x

J. K. Utvik, C. Haglerod, M. N. Mylonakou, T. Holen, M. Kropf et al., Neuronal enriched endosomal protein of 21 kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane, Neuroscience, vol.158, issue.1, pp.96-104, 2009.
DOI : 10.1016/j.neuroscience.2008.11.030

H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J. J. Lee et al., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nature Cell Biology, vol.175, issue.6, pp.654-659, 2007.
DOI : 10.1002/pmic.200400876

L. J. Vella, D. L. Greenwood, R. Cappai, J. P. Scheerlinck, and A. F. Hill, Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid, Veterinary Immunology and Immunopathology, vol.124, issue.3-4, pp.385-393, 2008.
DOI : 10.1016/j.vetimm.2008.04.002

L. J. Vella, R. A. Sharples, R. M. Nisbet, R. Cappai, and A. F. Hill, The role of exosomes in the processing of proteins associated with neurodegenerative diseases, European Biophysics Journal, vol.4, issue.Pt 16, pp.323-332, 2008.
DOI : 10.1007/s00249-007-0246-z

V. Vingtdeux, M. Hamdane, A. Loyens, P. Gele, H. Drobeck et al., Alkalizing Drugs Induce Accumulation of Amyloid Precursor Protein By-products in Luminal Vesicles of Multivesicular Bodies, Journal of Biological Chemistry, vol.282, issue.25, pp.18197-18205, 2007.
DOI : 10.1074/jbc.M609475200

C. C. Yap, D. Wisco, P. Kujala, Z. M. Lasiecka, J. T. Cannon et al., The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM, The Journal of Cell Biology, vol.1, issue.4, pp.827-842, 2008.
DOI : 10.1523/JNEUROSCI.0840-06.2006

H. G. Zhang, C. Liu, K. Su, S. Yu, L. Zhang et al., A Membrane Form of TNF-?? Presented by Exosomes Delays T Cell Activation-Induced Cell Death, The Journal of Immunology, vol.176, issue.12, pp.7385-7393, 2006.
DOI : 10.4049/jimmunol.176.12.7385