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Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts.

Abstract : Cyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the M-phase Promoting Factor or MPF. Studies performed during the last decade have shown many details of how CDK1 is regulated and also how it regulates the cell cycle progression. Xenopus laevis cell-free extracts were widely used to elucidate the details and to obtain a global view of the role of CDK1 in M-phase control. CDK1 inactivation upon M-phase exit is a primordial process leading to the M-phase/interphase transition during the cell cycle. Here we discuss two closely related aspects of CDK1 regulation in Xenopus laevis cell-free extracts: firstly, how CDK1 becomes inactivated and secondly, how other actors, like kinases and phosphatases network and/or specific inhibitors, cooperate with CDK1 inactivation to assure timely exit from the M-phase.
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https://www.hal.inserm.fr/inserm-00586916
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Submitted on : Monday, April 18, 2011 - 5:59:06 PM
Last modification on : Wednesday, May 16, 2018 - 11:22:34 AM
Long-term archiving on: : Tuesday, July 19, 2011 - 3:03:02 AM

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Jacek Kubiak, Mohammed El Dika. Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts.. Enzyme Research, Hindawi Publishing Corporation, 2011, 2011, pp.523420. ⟨10.4061/2011/523420⟩. ⟨inserm-00586916⟩

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