F. A. Dilmanian, Y. Qu, S. Liu, C. D. Cool, J. Gilbert et al., Therapeutic advantage of grid irradiation for large single fractions, Int. J. Radiat. Oncol. Biol. Phys, pp.58-1309, 2004.

J. Peñ-agarícano, R. Griffin, P. Corry, E. Moros, Y. Yan et al., Spatially fractionated (GRID) therapy for large and bulky tumors, J. Ark Med. Soc, vol.105, pp.263-265, 2009.

J. Peñ-agarícano, E. Moros, V. Ratanatharathorn, Y. Yan, and P. Corry, Evaluation of spatially fractionated radiotherapy (GRID) and definitive chemoradiotherapy with curative intent for locally advanced squamous cell carcinoma of the head and neck: initial response rates and toxicity, Int. J. Radiat. Oncol. Biol. Phys, vol.20, 2009.

H. Curtis, The Use of a Deuteron Microbeam for Simulating the Biological Effects of Heavy Cosmic-Ray Particles, Radiation Research Supplement, vol.7, pp.250-257, 1967.
DOI : 10.2307/3583718

H. J. Curtis, The Microbeam as a Tool in Radiobiology, Adv. Biol. Med. Phys, vol.175, pp.207-224, 1963.
DOI : 10.1016/B978-1-4832-3108-2.50008-0

D. N. Slatkin, P. Spanne, F. A. Dilmanian, and M. Sandborg, Microbeam radiation therapy, Medical Physics, vol.19, issue.6, pp.1395-1400, 1992.
DOI : 10.1118/1.596771

J. Laissue, P. Spanne, F. A. Dilmanian, J. O. Gebbers, and D. N. Slatkin, Zell-und Gewebelä sionen nach rä umlich fraktionierter Mikro-Bestrahlung des ZNS mit Synchrotron Photonen, Schweiz. Med. Wochenschr, pp.122-138, 1992.

D. N. Slatkin, P. Spanne, F. A. Dilmanian, J. O. Gebbers, and J. A. Laissue, Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler., Proceedings of the National Academy of Sciences, vol.92, issue.19, pp.92-8783, 1995.
DOI : 10.1073/pnas.92.19.8783

B. Larsson, Potentialities of synchrotron radiation in experimental and clinical radiation surgery, Acta Radiol, pp.58-64, 1983.

D. D. Joel, R. G. Fairchild, J. A. Laissue, S. K. Saraf, J. A. Kalef-ezra et al., Boron neutron capture therapy of intracerebral rat gliosarcomas., Proceedings of the National Academy of Sciences, vol.87, issue.24, pp.9808-9812, 1990.
DOI : 10.1073/pnas.87.24.9808

J. A. Laissue, G. Geiser, P. O. Spanne, F. A. Dilmanian, J. Gebbers et al., Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays, International Journal of Cancer, vol.14, issue.5, pp.654-660, 1998.
DOI : 10.1002/(SICI)1097-0215(19981123)78:5<654::AID-IJC21>3.0.CO;2-L

D. Archer, Collimator for Producing an Array of Microbeams, United States Patent, 1998.

P. M. Schweizer, P. Spanne, M. D. Michiel, U. Jauch, H. Blattmann et al., Tissue lesions caused by microplanar beams of synchrotron-generated X-rays in Drosophila melanogaster, Int. J. Radiat. Biol, pp.76-567, 2000.

J. A. Laissue, H. Blattmann, D. Michiel, D. N. Slatkin, N. Lyubimova et al., The weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neurooncology, Proc of SPIE, pp.65-73, 2001.

H. Blattmann, W. Burkard, V. Djonov, M. Dimichiel, E. Brauer et al., Microbeam irradiation of the chorio-allantoic membrane (CAM) of chicken embryo, Strahlenther. Onkol, vol.178, issue.118, 2002.

E. Bräuer-krisch, H. Requardt, P. Regnard, S. Corde, E. Siegbahn et al., New irradiation geometry for microbeam radiation therapy, Physics in Medicine and Biology, vol.50, issue.13, pp.50-3103, 2005.
DOI : 10.1088/0031-9155/50/13/009

F. A. Dilmanian, T. M. Button, G. Le-duc, N. Zhong, L. A. Pena et al., Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy, Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy, pp.26-38, 2002.
DOI : 10.1215/15228517-4-1-26

F. A. Dilmanian, G. M. Morris, N. Zhong, T. Bacarian, J. F. Hainfeld et al., Murine EMT-6 Carcinoma: High Therapeutic Efficacy of Microbeam Radiation Therapy, Radiation Research, vol.159, issue.5, pp.159-632, 2003.
DOI : 10.1667/0033-7587(2003)159[0632:MECHTE]2.0.CO;2

M. Miura, H. Blattmann, E. Brä-uer-krisch, A. Bravin, A. L. Hanson et al., Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams, The British Journal of Radiology, vol.79, issue.937, pp.79-71, 2006.
DOI : 10.1259/bjr/50464795

H. M. Smilowitz, H. Blattmann, E. Brä-uer-krisch, A. Bravin, M. D. Michiel et al., Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas, Journal of Neuro-Oncology, vol.64, issue.064303, pp.78-135, 2006.
DOI : 10.1007/s11060-005-9094-9

F. A. Dilmanian, G. M. Morris, G. Le-duc, X. Huang, B. Ren et al., Response of avian embryonic brain to spatially segmented X-ray microbeams, Cell. Mol. Biol, pp.47-485, 2001.

H. Blattmann, J. Gebbers, E. Brauer-krisch, A. Bravin, G. Le-duc et al., Applications of synchrotron X-rays to radiotherapy, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.548, issue.1-2, pp.17-22, 2005.
DOI : 10.1016/j.nima.2005.03.060

F. A. Dilmanian, Y. Qu, S. Liu, C. D. Cool, J. Gilbert et al., X-ray microbeams: Tumor therapy and central nervous system research, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.548, issue.1-2, pp.30-37, 2005.
DOI : 10.1016/j.nima.2005.03.062

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828126

F. A. Dilmanian, Y. Qu, L. E. Feinendegen, L. A. Pena, T. Bacarian et al., Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: Is a bystander effect involved?, Experimental Hematology, vol.35, issue.4, pp.69-77, 2007.
DOI : 10.1016/j.exphem.2007.01.014

H. Wagner, Cancer in childhood and supportive care, Supportive Care in Cancer, vol.7, issue.5, pp.293-294, 1999.
DOI : 10.1007/s005200050265

R. K. Mulhern, T. E. Merchant, A. Gajjar, W. E. Reddick, and L. E. Kun, Late neurocognitive sequelae in survivors of brain tumours in childhood, The Lancet Oncology, vol.5, issue.7, pp.399-408, 2004.
DOI : 10.1016/S1470-2045(04)01507-4

K. Ribi, C. Relly, M. A. Landolt, F. D. Alber, E. Boltshauser et al., Outcome of Medulloblastoma in Children: Long-Term Complications and Quality of Life, Neuropediatrics, vol.36, issue.6, pp.357-365, 2005.
DOI : 10.1055/s-2005-872880

B. Timmermann, R. Kortmann, J. Kuhl, S. Rutkowski, K. Dickmann et al., Role of radiotherapy in anaplastic ependymoma in children under age of 3 years: Results of the prospective German brain tumor trials HIT-SKK 87 and 92, Radiotherapy and Oncology, vol.77, issue.3, pp.77-278, 2005.
DOI : 10.1016/j.radonc.2005.10.016

R. Serduc, E. Brauer-krisch, A. Bouchet, L. Renaud, T. Brochard et al., First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy, Journal of Synchrotron Radiation, vol.16, issue.4, pp.16-587, 2009.
DOI : 10.1107/S0909049509012485

URL : https://hal.archives-ouvertes.fr/hal-00421096

D. J. Anschel, P. Romanelli, H. Benveniste, B. Foerster, J. Kalef-ezra et al., Evolution of a focal brain lesion produced by interlaced microplanar X-rays, Minim, Invas. Neurosurg, pp.50-93, 2007.

F. A. Dilmanian, Z. Zhong, T. Bacarian, H. Benveniste, P. Romanelli et al., Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential, Proceedings of the National Academy of Sciences, vol.103, issue.25, pp.9709-9714, 2006.
DOI : 10.1073/pnas.0603567103

R. Serduc, P. Verant, J. C. Vial, R. Farion, L. Rocas et al., In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.5, pp.1519-1527, 2006.
DOI : 10.1016/j.ijrobp.2005.11.047

URL : https://hal.archives-ouvertes.fr/inserm-00388979

R. H. Mole, Whole Body Irradiation???Radiobiology or Medicine?, The British Journal of Radiology, vol.26, issue.305, pp.234-241, 1953.
DOI : 10.1259/0007-1285-26-305-234

E. A. Siegbahn, E. Brä-uer-krisch, J. Stepanek, H. Blattmann, J. Laissue et al., Dosimetric studies of microbeam radiation therapy (MRT) with Monte Carlo simulations, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.548, issue.1-2, pp.54-58, 2005.
DOI : 10.1016/j.nima.2005.03.065

D. Slatkin, H. Blattmann, H. Wagner, M. A. Grotzer, and J. Laissue, ???Prospects for microbeam radiation therapy of brain tumours in children???, Developmental Medicine & Child Neurology, vol.33, issue.2, p.51, 2009.
DOI : 10.1111/j.1469-8749.2008.03187.x

E. Brä-uer-krisch, A. A. Bravin, E. Siegbahn, A. L. Zhang, J. Stepanek et al., Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European synchrotron radiation facility, Rev. Sci. Instrum, pp.76-77, 2005.

E. Brä-uer-krisch, H. Requardt, T. Brochard, G. Berruyer, M. Renier et al., New technology enables precision multi slit collimators for MRT (microbeam radiation therapy), Rev. Sci. Instrum

E. Brä-uer-krisch, Theoretical and Experimental Microdosimetry for MRT (Microbeam Radiation Therapy). Micro and Mini Dosimetry, 2005.

J. C. Crosbie, I. Svalbe, S. M. Midgley, N. Yagi, P. A. Rogers et al., A method of dosimetry for synchrotron microbeam radiation therapy using radiochromic films of different sensitivity, Physics in Medicine and Biology, vol.53, issue.23, pp.53-6861, 2008.
DOI : 10.1088/0031-9155/53/23/014

F. Z. Company and B. J. Allen, Calculation of microplanar beam dose profiles in a tissue/lung/tissue phantom, Physics in Medicine and Biology, vol.43, issue.9, pp.2491-2501, 1998.
DOI : 10.1088/0031-9155/43/9/005

J. Stepanek, H. Blattmann, J. A. Laissue, N. Lyubimova, M. D. Michiel et al., Physics study of microbeam radiation therapy with PSI-version of Monte Carlo code GEANT as a new computational tool, Medical Physics, vol.45, issue.3, pp.27-1664, 2000.
DOI : 10.1118/1.599034

M. De-felici, R. Felici, M. Sanchez-del-rio, C. Ferrero, T. Bacarian et al., Monte Carlo study, Medical Physics, vol.20, issue.8, pp.32-2455, 2005.
DOI : 10.1118/1.597071

J. Spiga, E. A. Siegbahn, E. Brä-uer-krisch, P. Randaccio, and A. Bravin, toolkit for microdosimetry calculations: Application to microbeam radiation therapy (MRT), Medical Physics, vol.31, issue.11, pp.34-4322, 2007.
DOI : 10.1118/1.1637970

I. Orion, A. B. Rosenfeld, F. A. Dilmanian, F. Telang, B. Ren et al., Monte Carlo simulation of dose distributions from a synchrotron-produced microplanar beam array using the EGS4 code system, Phys. Med. Biol, pp.45-2497, 2000.

E. A. Siegbahn, E. Brauer-krisch, A. Bravin, H. Nettelbeck, M. L. Lerch et al., MOSFET dosimetry with high spatial resolution in intense synchrotron-generated x-ray microbeams, Medical Physics, vol.28, issue.4, pp.36-1128, 2009.
DOI : 10.1118/1.1374247

H. Nettelbeck, G. J. Takacs, M. L. Lerch, and A. B. Rosenfeld, Microbeam radiation therapy: A Monte Carlo study of the influence of the source, multislit collimator, and beam divergence on microbeams, Medical Physics, vol.12, issue.2, pp.36-447, 2009.
DOI : 10.1107/S0909049504028444

E. Schü-ltke, B. H. Juurlink, K. Ataelmannan, J. Laissue, H. Blattmann et al., Memory and survival after microbeam radiation therapy, Eur. J. Radiol, pp.68-142, 2008.

P. Regnard, G. L. Duc, E. Brä-uer-krisch, I. Tropres, E. A. Siegbahn et al., Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing, Physics in Medicine and Biology, vol.53, issue.4, pp.53-861, 2008.
DOI : 10.1088/0031-9155/53/4/003

P. Regnard, E. Brä-uer-krisch, I. Tropes, J. Keyrilainen, A. Bravin et al., Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy, European Journal of Radiology, vol.68, issue.3, pp.68-151, 2008.
DOI : 10.1016/j.ejrad.2008.04.049

Y. Prezado, G. Fois, G. L. Duc, and A. Bravin, Gadolinium dose enhancement studies in microbeam radiation therapy, Medical Physics, vol.22, issue.8, pp.3568-3574, 2008.
DOI : 10.1118/1.597545

C. Alric, R. Serduc, C. Mandon, J. Taleb, G. L. Duc et al., Gold nanoparticles designed for combining dual modality imaging and radiotherapy, Gold Bulletin, vol.1669, issue.2, pp.41-90, 2008.
DOI : 10.1007/BF03216586

URL : https://hal.archives-ouvertes.fr/hal-00433978

R. Serduc, T. Christen, J. Laissue, R. Farion, A. Bouchet et al., Brain tumor vessel response to synchrotron microbeam radiation therapy: a short-term in vivo study, Phys. Med. Biol, pp.53-3609, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00381397

T. E. Schultheiss, L. E. Kun, K. K. Ang, and L. C. Stephens, Radiation response of the central nervous system, International Journal of Radiation Oncology*Biology*Physics, vol.31, issue.5, pp.31-1093, 1995.
DOI : 10.1016/0360-3016(94)00655-5

G. M. Kiebert, D. Curran, N. K. Aaronson, M. Bolla, J. Menten et al., Quality of life after radiation therapy of cerebral low-grade gliomas of the adult: results of a randomised Phase III trial on dose response (EORTC trial 22844), European Journal of Cancer, vol.34, issue.12, pp.1902-1909, 1998.
DOI : 10.1016/S0959-8049(98)00268-8

A. Skowronska-gardas, K. Pedziwiatr, and M. Chojnacka, Evaluation of quality of life in long-term survivors of paediatric brain stem tumors, treated with radiotherapy, Radiotherapy and Oncology, vol.70, issue.3, pp.70-269, 2004.
DOI : 10.1016/j.radonc.2004.01.008

N. Zhong, G. M. Morris, T. Bacarian, E. M. Rosen, and F. A. Dilmanian, Response of Rat Skin to High-Dose Unidirectional X-Ray Microbeams: A Histological Study, Radiation Research, vol.160, issue.2, pp.160-133, 2003.
DOI : 10.1667/3033

F. A. Dilmanian, J. Kalef-ezra, M. J. Petersen, G. Bozios, J. Vosswinkel et al., Could X-ray microbeams inhibit angioplasty-induced restenosis in the rat carotid artery?, Cardiovascular Radiation Medicine, vol.4, issue.3, pp.139-145, 2003.
DOI : 10.1016/S1522-1865(03)00180-X

J. A. Laissue, H. Blattmann, H. P. Wagner, M. A. Grotzer, and D. N. Slatkin, Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae, Developmental Medicine & Child Neurology, vol.76, issue.8, pp.49-577, 2007.
DOI : 10.1111/j.1469-8749.2007.00577.x

K. Fischer-dzoga, G. S. Dimitrievich, and M. L. Griem, Radiosensitivity of Vascular Tissue: II. Differential Radiosensitivity of Aortic Cells in Vitro, Radiation Research, vol.99, issue.3, pp.99-536, 1984.
DOI : 10.2307/3576328

D. J. Brenner, R. C. Miller, and E. J. Hall, The radiobiology of intravascular irradiation, International Journal of Radiation Oncology*Biology*Physics, vol.36, issue.4, pp.805-810, 1996.
DOI : 10.1016/S0360-3016(96)00414-2

L. A. Pena, Z. Fuks, and R. N. Kolesnick, Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency, Cancer Res, pp.60-321, 2000.

M. Fuss, F. Wenz, R. Scholdei, M. Essig, J. Debus et al., Radiation-induced regional cerebral blood volume (rCBV) changes in normal brain and low-grade astrocytomas: quantification and time and dose-dependent occurrence, International Journal of Radiation Oncology*Biology*Physics, vol.48, issue.1, pp.48-53, 2000.
DOI : 10.1016/S0360-3016(00)00590-3

R. Serduc, Y. Van-de-looij, G. Francony, O. Verdonck, B. Van-der-sanden et al., Characterization and quantification of cerebral edema induced by synchrotron x-ray microbeam radiation therapy, Physics in Medicine and Biology, vol.53, issue.5, pp.53-1153, 2008.
DOI : 10.1088/0031-9155/53/5/001

URL : https://hal.archives-ouvertes.fr/inserm-00381404

M. Van-vulpen, H. B. Kal, M. J. Taphoorn, and S. Y. El-sharouni, Changes in blood-brain barrier permeability induced by radiotherapy: Implications for timing of chemotherapy? (Review), Oncology Reports, vol.9, pp.683-688, 2002.
DOI : 10.3892/or.9.4.683

S. Taki, K. Higashi, M. Oguchi, H. Tamamura, S. Tsuji et al., Changes in regional cerebral blood flow in irradiated regions and normal brain after stereotactic radiosurgery, Annals of Nuclear Medicine, vol.48, issue.4, pp.16-273, 2002.
DOI : 10.1007/BF03000106

J. Folkman, Seminars in Medicine of the Beth Israel Hospital Clinical applications of research on angiogenesis, N. Engl. J. Med, vol.333, pp.1757-1763, 1995.

G. D. Yancopoulos, S. Davis, N. W. Gale, J. S. Rudge, S. J. Wiegand et al., Vascularspecific growth factors and blood vessel formation, Nature, vol.407, issue.6801, pp.242-248, 2000.
DOI : 10.1038/35025215

R. Serduc, B. Lemasson, and A. Bouchet, Rat brain tumor palliation by microbeam radiation therapy, the vascular component

P. Andreo, D. T. Burns, K. Hohlfeld, M. Huq, T. Kanai et al., Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry Based Standards of Absorbed Dose to Water, 2004.

Y. Prezado, G. Fois, M. Edouard, C. Nemoz, M. Renier et al., Biological equivalent dose studies for dose escalation in the stereotactic synchrotron radiation therapy clinical trials, Medical Physics, vol.51, issue.3, pp.36-725, 2009.
DOI : 10.1088/0031-9155/51/22/013

URL : https://hal.archives-ouvertes.fr/inserm-00381871

G. S. Ibbot, Specification and Acceptance Testing in Radiotherapy Treatment Planning Systems, IAEA, 2007.

M. Ptaszkiewicza, E. Bräuer-krisch, M. Klosowski, L. Czopyk, and P. Olko, TLD dosimetry for microbeam radiation therapy at the ESRF, Radiat. Meas, pp.43-990, 2008.

E. Brä-uer-krisch, A. Bravin, M. Lerch, A. Rosenfeld, J. Stepanek et al., MOSFET dosimetry for microbeam radiation therapy at the European synchrotron radiation facility, Med. Phys, pp.30-583, 2003.

P. Romanelli and D. J. , Radiosurgery for epilepsy, The Lancet Neurology, vol.5, issue.7, pp.613-620, 2006.
DOI : 10.1016/S1474-4422(06)70496-3

R. Serduc, E. Brä-uer-krisch, E. A. Siegbahn, A. Bouchet, B. Pouyatos et al., High-Precision Radiosurgical Dose Delivery by Interlaced Microbeam Arrays of High-Flux Low-Energy Synchrotron X-Rays, PLoS ONE, vol.5, issue.2
DOI : 10.1371/journal.pone.0009028.t001

URL : https://hal.archives-ouvertes.fr/hal-00456405

E. C. Mackonis, N. Suchowerska, M. Zhang, M. Ebert, D. R. Mckenzie et al., Cellular response to modulated radiation fields, Phys. Med. Biol, pp.52-5469, 2007.

E. A. Siegbahn, J. Stepanek, E. Bräuer-krisch, and A. , Bravin, Determination of dosimetrical quantities used in microbeam radiation therapy (MRT) with Monte Carlo simulations, Med. Phys, pp.33-3248, 2006.