D. Goodenough and D. Paul, Gap junctions. Cold Spring Harbor Perspect Biol, p.2576, 2009.

G. Cottrell and J. Burt, Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1711, issue.2, pp.126-141, 2005.
DOI : 10.1016/j.bbamem.2004.11.013

A. Brisset, B. Isakson, and B. Kwak, Connexins in Vascular Physiology and Pathology, Antioxidants & Redox Signaling, vol.11, issue.2, pp.267-282, 2009.
DOI : 10.1089/ars.2008.2115

N. Rummery and C. Hill, Vascular gap junctions and implications for hypertension, Clinical and Experimental Pharmacology and Physiology, vol.39, issue.10, pp.659-667, 2004.
DOI : 10.1002/1526-968X(200101)29:1<1::AID-GENE1000>3.0.CO;2-0

D. Cowan, M. Jones, L. Garcia, S. Noria, P. Del-nido et al., Hypoxia and Stretch Regulate Intercellular Communication in Vascular Smooth Muscle Cells Through Reactive Oxygen Species Formation, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.23, issue.10, pp.1754-1760, 2003.
DOI : 10.1161/01.ATV.0000093546.10162.B2

M. Humbert, O. Sitbon, and G. Simonneau, Treatment of Pulmonary Arterial Hypertension, New England Journal of Medicine, vol.351, issue.14, pp.1425-1436, 2004.
DOI : 10.1056/NEJMra040291

URL : https://hal.archives-ouvertes.fr/hal-01455600

G. Simonneau, I. Robbins, M. Beghetti, R. Channick, M. Delcroix et al., Updated Clinical Classification of Pulmonary Hypertension, Journal of the American College of Cardiology, vol.54, issue.1, pp.43-54, 2009.
DOI : 10.1016/j.jacc.2009.04.012

M. Humbert, Update in Pulmonary Hypertension 2008, American Journal of Respiratory and Critical Care Medicine, vol.179, issue.8, pp.650-656, 2008.
DOI : 10.1164/rccm.200901-0136UP

A. Giaid, M. Yanagisawa, D. Langleben, R. Michel, R. Levy et al., Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension, New England Journal of Medicine, vol.328, issue.24, pp.1732-1739, 1993.
DOI : 10.1056/NEJM199306173282402

P. Herve, J. Launay, M. Scrobohaci, F. Brenot, G. Simonneau et al., Increased plasma serotonin in primary pulmonary hypertension, The American Journal of Medicine, vol.99, issue.3, pp.249-254, 1995.
DOI : 10.1016/S0002-9343(99)80156-9

Y. Hosoda, Pathology of pulmonary hypertension: A human and experimental study, Pathology International, vol.328, issue.4, pp.241-267, 1994.
DOI : 10.1111/j.1440-1827.1994.tb03363.x

Y. Kanai, S. Hori, T. Tanaka, M. Yasuoka, K. Watanabe et al., Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats, Cardiovascular Research, vol.27, issue.9, pp.1619-1623, 1993.
DOI : 10.1093/cvr/27.9.1619

T. Miyauchi, R. Yorikane, S. Sakai, T. Sakurai, M. Okada et al., Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension, Circulation Research, vol.73, issue.5, pp.887-897, 1993.
DOI : 10.1161/01.RES.73.5.887

S. Salvi, ??1-Adrenergic Hypothesis for Pulmonary Hypertension, Chest, vol.115, issue.6, pp.1708-1719, 1999.
DOI : 10.1378/chest.115.6.1708

M. Humbert, N. Morrell, S. Archer, K. Stenmark, M. Maclean et al., Cellular and molecular pathobiology of pulmonary arterial hypertension, Journal of the American College of Cardiology, vol.43, issue.12, pp.13-24, 2004.
DOI : 10.1016/j.jacc.2004.02.029

L. Shimoda, J. Sham, and J. Sylvester, Altered pulmonary vasoreactivity in the chronically hypoxic lung, Physiol Res, vol.49, pp.549-560, 2000.

C. Guibert, R. Marthan, and J. Savineau, Modulation of Ion Channels in Pulmonary Arterial Hypertension, Current Pharmaceutical Design, vol.13, issue.24, pp.2443-2455, 2007.
DOI : 10.2174/138161207781368585

M. Billaud, R. Marthan, J. Savineau, and C. Guibert, Vascular Smooth Muscle Modulates Endothelial Control of Vasoreactivity via Reactive Oxygen Species Production through Myoendothelial Communications, PLoS ONE, vol.27, issue.1, p.6432, 2009.
DOI : 10.1371/journal.pone.0006432.s010

A. Chaytor, W. Evans, and T. Griffith, Peptides Homologous to Extracellular Loop Motifs of Connexin 43 Reversibly Abolish Rhythmic Contractile Activity in Rabbit Arteries, The Journal of Physiology, vol.79, issue.1, pp.50399-110, 1997.
DOI : 10.1111/j.1469-7793.1997.099bi.x

S. Tual-chalot, C. Guibert, B. Muller, J. Savineau, R. Andriantsitohaina et al., Circulating Microparticles from Pulmonary Hypertensive Rats Induce Endothelial Dysfunction, American Journal of Respiratory and Critical Care Medicine, vol.182, issue.2, pp.261-268, 2010.
DOI : 10.1164/rccm.200909-1347OC

URL : https://hal.archives-ouvertes.fr/hal-01389219

L. Rodat-despoix, H. Crevel, R. Marthan, J. Savineau, and C. Guibert, Heterogeneity in 5-HT-Induced Contractile and Proliferative Responses in Rat Pulmonary Arterial Bed, Journal of Vascular Research, vol.45, issue.3, pp.181-192, 2008.
DOI : 10.1159/000111071

L. Rodat, J. Savineau, R. Marthan, and C. Guibert, Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries, Pfl??gers Archiv - European Journal of Physiology, vol.272, issue.Pt 3, pp.41-51, 2007.
DOI : 10.1007/s00424-006-0178-y

C. Guibert, J. Savineau, H. Crevel, R. Marthan, and E. Rousseau, Effect of short-term organoid culture on the pharmaco-mechanical properties of rat extra- and intrapulmonary arteries, British Journal of Pharmacology, vol.264, issue.5, pp.692-701, 2005.
DOI : 10.1073/pnas.0405908101

A. Keegan, I. Morecroft, D. Smillie, M. Hicks, and M. Maclean, Contribution of the 5-HT1B Receptor to Hypoxia-Induced Pulmonary Hypertension: Converging Evidence Using 5-HT1B-Receptor Knockout Mice and the 5-HT1B/1D-Receptor Antagonist GR127935, Circulation Research, vol.89, issue.12, pp.1231-1239, 2001.
DOI : 10.1161/hh2401.100426

M. Maclean, G. Sweeney, M. Baird, K. Mcculloch, and M. Houslay, 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats, British Journal of Pharmacology, vol.267, issue.Suppl. 7, pp.917-930, 1996.
DOI : 10.1111/j.1476-5381.1996.tb15760.x

S. Sauvageau, E. Thorin, L. Villeneuve, and J. Dupuis, Change in pharmacological effect of endothelin receptor antagonists in rats with pulmonary hypertension: Role of ETB-receptor expression levels, Pulmonary Pharmacology & Therapeutics, vol.22, issue.4, pp.311-317, 2009.
DOI : 10.1016/j.pupt.2009.01.006

M. Maclean, K. Mcculloch, and M. Baird, Endothelin ETA- and ETB-Receptor-Mediated Vasoconstriction in Rat Pulmonary Arteries and Arterioles, Journal of Cardiovascular Pharmacology, vol.23, issue.5, pp.838-845, 1994.
DOI : 10.1097/00005344-199405000-00022

V. Mam, A. Tanbe, S. Vitali, E. Arons, H. Christou et al., Impaired Vasoconstriction and Nitric Oxide-Mediated Relaxation in Pulmonary Arteries of Hypoxia- and Monocrotaline-Induced Pulmonary Hypertensive Rats, Journal of Pharmacology and Experimental Therapeutics, vol.332, issue.2, pp.455-462, 2010.
DOI : 10.1124/jpet.109.160119

S. Bonnet, E. Dubuis, C. Vandier, S. Martin, R. Marthan et al., Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing, Cardiovascular Research, vol.53, issue.4, pp.1019-1028, 2002.
DOI : 10.1016/S0008-6363(01)00548-X

J. Hyvelin, C. Guibert, R. Marthan, and J. Savineau, Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arterial myocytes, Am J Physiol, vol.275, pp.269-282, 1998.

D. Ivy, I. Mcmurtry, M. Yanagisawa, C. Gariepy, L. Cras et al., Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction, Am J Physiol Lung Cell Mol Physiol, vol.280, pp.1040-1048, 2001.

C. Guibert, R. Marthan, and J. Savineau, 5-HT induces an arachidonic acid-sensitive calcium influx in rat small intrapulmonary artery, AJP: Lung Cellular and Molecular Physiology, vol.286, issue.6, pp.1228-1236, 2004.
DOI : 10.1152/ajplung.00265.2003

S. Mcdaniel, O. Platoshyn, J. Wang, Y. Yu, M. Sweeney et al., Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction, Am J Physiol Lung Cell Mol Physiol, vol.280, pp.870-880, 2001.

L. Shimoda, J. Sylvester, and J. Sham, Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells, Am J Physiol Lung Cell Mol Physiol, vol.278, pp.157-164, 2000.

S. Barman, Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C, AJP: Lung Cellular and Molecular Physiology, vol.293, issue.2, pp.472-479, 2007.
DOI : 10.1152/ajplung.00101.2006

L. Rodat-despoix, V. Aires, T. Ducret, R. Marthan, J. Savineau et al., Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery, European Respiratory Journal, vol.34, issue.6, pp.1338-1347, 2009.
DOI : 10.1183/09031936.00143808

V. Sauzeau, L. Jeune, H. Cario-toumaniantz, C. Smolenski, A. Lohmann et al., Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle, Journal of Biological Chemistry, vol.275, issue.28, pp.21722-21729, 2000.
DOI : 10.1074/jbc.M000753200

C. De-wit and T. Griffith, Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses, Pfl??gers Archiv - European Journal of Physiology, vol.118, issue.6, pp.897-914, 2010.
DOI : 10.1007/s00424-010-0830-4

. Billaud, http://respiratory-research.com/content, Respiratory Research, vol.12121, p.3030, 2011.