Residual HIV-1 RNA in Blood Plasma of Patients Taking Suppressive Highly Active Antiretroviral Therapy, JAMA, vol.282, issue.17, pp.1627-1632, 1999. ,
DOI : 10.1001/jama.282.17.1627
Residual HIV-RNA Levels Persist for Up to 2.5 Years in Peripheral Blood Mononuclear Cells of Patients on Potent Antiretroviral Therapy, AIDS Research and Human Retroviruses, vol.16, issue.12, pp.1135-1140, 2000. ,
DOI : 10.1089/088922200414974
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy, Proceedings of the National Academy of Sciences, vol.106, issue.23, pp.9403-9408, 2009. ,
DOI : 10.1073/pnas.0903107106
Delta32/Delta32 Stem-Cell Transplantation, New England Journal of Medicine, vol.360, issue.7, pp.692-698, 2009. ,
DOI : 10.1056/NEJMoa0802905
T Cells Using a Combination of Cytokines, The Journal of Experimental Medicine, vol.32, issue.1, pp.83-91, 1998. ,
DOI : 10.1126/science.271.5255.1582
Macrophages and residual HIV infection, Curr Opin HIV AIDS, vol.1, pp.129-133, 2006. ,
Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection, Journal of Virology, vol.80, issue.16, pp.8236-8247, 2006. ,
DOI : 10.1128/JVI.00120-06
Persistence of HIV in Gut???Associated Lymphoid Tissue despite Long???Term Antiretroviral Therapy, The Journal of Infectious Diseases, vol.197, issue.5, pp.714-720, 2008. ,
DOI : 10.1086/527324
Human Immunodeficiency Virus Type 1 in the Semen of Men Receiving Highly Active Antiretroviral Therapy, New England Journal of Medicine, vol.339, issue.25, pp.1803-1809, 1998. ,
DOI : 10.1056/NEJM199812173392502
Persistence of Human Immunodeficiency Virus in Semen After Adding Indinavir to Combination Antiretroviral Therapy, Clinical Infectious Diseases, vol.28, issue.6, pp.1252-1259, 1999. ,
DOI : 10.1086/514775
Validation of the CNS Penetration-Effectiveness Rank for Quantifying Antiretroviral Penetration Into the Central Nervous System, Archives of Neurology, vol.65, issue.1, pp.65-70, 2008. ,
DOI : 10.1001/archneurol.2007.31
Persistence of replication-competent HIV in the central nervous system despite long-term effective highly active antiretroviral therapy, AIDS, vol.19, issue.2, pp.217-218, 2005. ,
DOI : 10.1097/00002030-200501280-00018
The relation between baseline HIV drug resistance and response to antiretroviral therapy: re-analysis of retrospective and prospective studies using a standardized data analysis plan, Antivir Ther, vol.5, pp.41-48, 2000. ,
The prevalence of antiretroviral drug resistance in the United States, AIDS, vol.18, issue.10, pp.1393-1401, 2004. ,
DOI : 10.1097/01.aids.0000131310.52526.c7
Understanding and managing the adverse effects of antiretroviral therapy, Antiviral Research, vol.85, issue.1, pp.201-209, 2010. ,
DOI : 10.1016/j.antiviral.2009.10.016
Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection, Proceedings of the National Academy of Sciences, vol.95, issue.15, pp.8869-8873, 1998. ,
DOI : 10.1073/pnas.95.15.8869
Rapid Accumulation of Human Immunodeficiency Virus (HIV) in Lymphatic Tissue Reservoirs during Acute and Early HIV Infection: Implications for Timing of Antiretroviral Therapy, The Journal of Infectious Diseases, vol.181, issue.1, pp.354-357, 2000. ,
DOI : 10.1086/315178
HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection, Nature, vol.424, issue.6945, pp.213-219, 2003. ,
DOI : 10.1038/nature01749
HIV-1 transmission and function of virus-infected monocytes/macrophages, J Immunol, vol.144, pp.2152-2158, 1990. ,
Rapid and Efficient Cell-to-Cell Transmission of Human Immunodeficiency Virus Infection from Monocyte-Derived Macrophages to Peripheral Blood Lymphocytes, Virology, vol.265, issue.2, pp.319-329, 1999. ,
DOI : 10.1006/viro.1999.0047
HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages, Nat Med, vol.5, pp.997-1003, 1999. ,
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes, Nature Medicine, vol.84, issue.2, pp.129-134, 1995. ,
DOI : 10.1016/0092-8674(88)90078-5
T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor, The Journal of Experimental Medicine, vol.10, issue.1, pp.55-64, 1997. ,
DOI : 10.1074/jbc.271.22.12687
Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes, J Virol, vol.72, pp.660-670, 1998. ,
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4, Nature, vol.395, pp.189-194, 1998. ,
Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy, Science, vol.233, issue.4768, pp.1089-1093, 1986. ,
DOI : 10.1126/science.3016903
Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia, Annals of Neurology, vol.68, issue.5, pp.755-762, 1995. ,
DOI : 10.1002/ana.410380510
Influence of HAART on HIV-Related CNS Disease and Neuroinflammation, Journal of Neuropathology & Experimental Neurology, vol.64, issue.6, pp.529-536, 2005. ,
DOI : 10.1093/jnen/64.6.529
Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes, Journal of Experimental Medicine, vol.167, issue.4, pp.1428-1441, 1988. ,
DOI : 10.1084/jem.167.4.1428
Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir, Antiviral Research, vol.55, issue.2, pp.209-225, 2002. ,
DOI : 10.1016/S0166-3542(02)00052-9
In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages, J Leukoc Biol, vol.56, pp.381-386, 1994. ,
HIV-1: Fifteen Proteins and an RNA, Annual Review of Biochemistry, vol.67, issue.1, pp.1-25, 1998. ,
DOI : 10.1146/annurev.biochem.67.1.1
Host factors exploited by retroviruses, Nature Reviews Microbiology, vol.100, issue.4, pp.253-263, 2007. ,
DOI : 10.1038/nrmicro1541
The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic, Antiviral Research, vol.85, issue.1, pp.1-18, 2010. ,
DOI : 10.1016/j.antiviral.2009.10.002
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen, Science, vol.319, issue.5865, pp.921-926, 2008. ,
DOI : 10.1126/science.1152725
Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication, Cell, vol.135, issue.1, pp.49-60, 2008. ,
DOI : 10.1016/j.cell.2008.07.032
A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication, Journal of Biological Chemistry, vol.284, issue.29, pp.19463-19473, 2009. ,
DOI : 10.1074/jbc.M109.010033
Genome-Scale RNAi Screen for Host Factors Required for HIV Replication, Cell Host & Microbe, vol.4, issue.5, pp.495-504, 2008. ,
DOI : 10.1016/j.chom.2008.10.004
Donor variation in in vitro HIV-1 susceptibility of monocyte-derived macrophages, Virology, vol.390, issue.2, pp.205-211, 2009. ,
DOI : 10.1016/j.virol.2009.05.027
Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro, J Virol, vol.70, pp.7792-7803, 1996. ,
Analysis of Cellular Factors Influencing the Replication of Human Immunodeficiency Virus Type I in Human Macrophages Derived from Blood of Different Healthy Donors, Virology, vol.286, issue.1, pp.31-44, 2001. ,
DOI : 10.1006/viro.2001.0940
HIV-1 macrophage tropism is determined at multiple levels of the viral replication cycle., Journal of Clinical Investigation, vol.94, issue.5, pp.1806-1814, 1994. ,
DOI : 10.1172/JCI117529
Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages by using twins, J Virol, vol.73, pp.4866-4881, 1999. ,
Common Genetic Variation and the Control of HIV-1 in Humans, PLoS Genetics, vol.18, issue.12, p.1000791, 2009. ,
DOI : 10.1371/journal.pgen.1000791.s016
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes, 2009. ,
Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03), The Journal of Infectious Diseases, vol.200, issue.8, 2009. ,
DOI : 10.1086/605892
Multistage Genomewide Association Study Identifies a Locus at 1q41 Associated with Rate of HIV???1 Disease Progression to Clinical AIDS, The Journal of Infectious Diseases, vol.201, issue.4, pp.618-626, 2010. ,
DOI : 10.1086/649842
A new multipoint method for genome-wide association studies by imputation of genotypes, Nature Genetics, vol.164, issue.7, pp.906-913, 2007. ,
DOI : 10.1038/nrg1916
Genomic Databases and Resources at the National Center for Biotechnology Information, Methods Mol Biol, vol.609, pp.17-44, 2010. ,
DOI : 10.1007/978-1-60327-241-4_2
Haploview: analysis and visualization of LD and haplotype maps, Bioinformatics, vol.21, issue.2, pp.263-265, 2005. ,
DOI : 10.1093/bioinformatics/bth457
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap, Bioinformatics, vol.24, issue.24, pp.2938-2939, 2008. ,
DOI : 10.1093/bioinformatics/btn564
SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies, Nucleic Acids Research, vol.37, issue.Web Server, pp.600-605, 2009. ,
DOI : 10.1093/nar/gkp290
Human T cell transcription factor GATA-3 stimulates HIV-1 expression, Nucleic Acids Research, vol.21, issue.12, pp.2831-2836, 1993. ,
DOI : 10.1093/nar/21.12.2831
The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells, Immunity, vol.6, issue.3, pp.235-244, 1997. ,
DOI : 10.1016/S1074-7613(00)80326-X
CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4+ T cells, Proceedings of the National Academy of Sciences, vol.94, issue.16, pp.8714-8719, 1997. ,
DOI : 10.1073/pnas.94.16.8714
CCAAT/Enhancer Binding Proteins Are Not Required for HIV-1 Entry but Regulate Proviral Transcription by Recruiting Coactivators to the Long-Terminal Repeat in Monocytic Cells, Virology, vol.299, issue.1, pp.20-31, 2002. ,
DOI : 10.1006/viro.2002.1500
Entry and Transcription as Key Determinants of Differences in CD4 T-Cell Permissiveness to Human Immunodeficiency Virus Type 1 Infection, Journal of Virology, vol.78, issue.19, pp.10747-10754, 2004. ,
DOI : 10.1128/JVI.78.19.10747-10754.2004
DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis, The Scientific World JOURNAL, vol.6, pp.1911-1922, 2006. ,
DOI : 10.1100/tsw.2006.319
The MNB/DYRK1A protein kinase: Genetic and biochemical properties, J Neural Transm, pp.139-148, 2003. ,
DOI : 10.1007/978-3-7091-6721-2_12
Transcriptional Dysregulation in Down Syndrome: Predictions for Altered Protein Complex Stoichiometries and Post-translational Modifications, and Consequences for Learning/Behavior Genes ELK, CREB, and the Estrogen and Glucocorticoid Receptors, Behavior Genetics, vol.12, issue.3, pp.439-453, 2006. ,
DOI : 10.1007/s10519-006-9051-1
The MNB/DYRK1A protein kinase: Neurobiological functions and Down syndrome implications, J Neural Transm, pp.129-137, 2003. ,
DOI : 10.1007/978-3-7091-6721-2_11
Function and regulation of Dyrk1A: towards understanding Down syndrome, Cellular and Molecular Life Sciences, vol.459, issue.20, pp.3235-3240, 2009. ,
DOI : 10.1007/s00018-009-0123-2
Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways, European Journal of Paediatric Neurology, vol.12, issue.3, pp.168-182, 2008. ,
DOI : 10.1016/j.ejpn.2007.08.010
Protein Kinase Dyrk1 Activates cAMP Response Element-binding Protein during Neuronal Differentiation in Hippocampal Progenitor Cells, Journal of Biological Chemistry, vol.276, issue.43, pp.39819-39824, 2001. ,
DOI : 10.1074/jbc.M104091200
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site, Biochemical Journal, vol.355, issue.3, pp.597-607, 2001. ,
DOI : 10.1042/bj3550597
Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1, Journal of Biological Chemistry, vol.277, issue.38, pp.35156-35161, 2002. ,
DOI : 10.1074/jbc.M206743200
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT, Nature, vol.2, issue.7093, pp.646-650, 2006. ,
DOI : 10.1038/nature04631
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21, Nature, vol.100, issue.7093, pp.595-600, 2006. ,
DOI : 10.1038/nature04678
Structural and Functional Characteristics of Dyrk, a Novel Subfamily of Protein Kinases with Dual Specificity, Prog Nucleic Acid Res Mol Biol, vol.62, pp.1-17, 1999. ,
DOI : 10.1016/S0079-6603(08)60503-6
Cystatin B Associates with Signal Transducer and Activator of Transcription 1 in Monocyte-Derived and Placental Macrophages, Placenta, vol.30, issue.5, pp.464-467, 2009. ,
DOI : 10.1016/j.placenta.2009.03.003
Primitive hematopoietic cells resist HIV-1 infection via p21Waf1/Cip1/Sdi1, Journal of Clinical Investigation, vol.117, issue.2, pp.473-481, 2007. ,
DOI : 10.1172/JCI28971DS1
Drug 9AA reactivates p21/Waf1 and inhibits HIV-1 progeny formation, Virology Journal, vol.5, issue.1, p.41, 2008. ,
DOI : 10.1186/1743-422X-5-41
The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc??R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages, Journal of Virology, vol.83, issue.23, pp.12253-12265, 2009. ,
DOI : 10.1128/JVI.01395-09
miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1, PLoS Pathogens, vol.70, issue.1, p.1000263, 2009. ,
DOI : 10.1371/journal.ppat.1000263.g008
Transcriptional Restriction of Human Immunodeficiency Virus Type 1 Gene Expression in Undifferentiated Primary Monocytes, Journal of Virology, vol.83, issue.8, pp.3518-3527, 2009. ,
DOI : 10.1128/JVI.02665-08
MAP-1, a Novel Proapoptotic Protein Containing a BH3-like Motif That Associates with Bax through Its Bcl-2 Homology Domains, Journal of Biological Chemistry, vol.276, issue.4, pp.2802-2807, 2001. ,
DOI : 10.1074/jbc.M008955200
Cell death and immunity: Apoptosis as an HIV strategy to escape immune attack, Nature Reviews Immunology, vol.3, issue.5, pp.392-404, 2003. ,
DOI : 10.1038/nri1087
Induction of Cell Death in Human Immunodeficiency Virus-Infected Macrophages and Resting Memory CD4 T Cells by TRAIL/Apo2L, Journal of Virology, vol.75, issue.22, pp.11128-11136, 2001. ,
DOI : 10.1128/JVI.75.22.11128-11136.2001
TRAIL-Mediated Apoptosis in HIV-1-Infected Macrophages Is Dependent on the Inhibition of Akt-1 Phosphorylation, The Journal of Immunology, vol.177, issue.4, pp.2304-2313, 2006. ,
DOI : 10.4049/jimmunol.177.4.2304
A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons, Molecular and Cellular Biology, vol.25, issue.16, pp.7120-7136, 2005. ,
DOI : 10.1128/MCB.25.16.7120-7136.2005
Degradation of HIV-1 Integrase by the N-end Rule Pathway, Journal of Biological Chemistry, vol.275, issue.38, pp.29749-29753, 2000. ,
DOI : 10.1074/jbc.M004670200
Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes, Cancer Res, vol.61, pp.8896-8902, 2001. ,
Angiogenic potential in vivo by Kaposi??s sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2, AIDS, vol.8, issue.9, pp.1237-1244, 1994. ,
DOI : 10.1097/00002030-199409000-00004
Activation of Matrix-Metalloproteinase-2 and Membrane-Type-1-Matrix-Metalloproteinase in Endothelial Cells and Induction of Vascular Permeability In Vivo by Human Immunodeficiency Virus-1 Tat Protein and Basic Fibroblast Growth Factor, Molecular Biology of the Cell, vol.12, issue.10, pp.2934-2946, 2001. ,
DOI : 10.1091/mbc.12.10.2934
HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1741, issue.1-2, pp.55-64, 2005. ,
DOI : 10.1016/j.bbadis.2004.12.001
Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia, Annals of Neurology, vol.161, issue.3, pp.391-398, 1999. ,
DOI : 10.1002/1531-8249(199909)46:3<391::AID-ANA15>3.0.CO;2-0
Increased activity of matrix metalloproteinase-2 in human glial and neuronal cell lines treated with HIV-1 gp41 peptides, Journal of Molecular Neuroscience, vol.9, issue.2, pp.129-141, 1998. ,
DOI : 10.1007/BF02737124
Human immunodeficiency virus type 1, human protein interaction database at NCBI, Nucleic Acids Research, vol.37, issue.Database, pp.417-422, 2009. ,
DOI : 10.1093/nar/gkn708
HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway, The FASEB Journal, vol.15, issue.2, pp.483-491, 2001. ,
DOI : 10.1096/fj.00-0354com
Prostaglandin E2 inhibits replication of HIV-1 in macrophages through activation of protein kinase A, Cellular Immunology, vol.215, issue.1, pp.61-71, 2002. ,
DOI : 10.1016/S0008-8749(02)00017-5
The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma, Journal of Leukocyte Biology, vol.87, issue.4, pp.627-632, 2010. ,
DOI : 10.1189/jlb.0809564
Who likes kinases? Drug Discovery, Development, vol.10, pp.18-22, 2007. ,
Power of selective genotyping in genetic association analyses of quantitative traits, Behavior Genetics, vol.30, issue.2, pp.141-146, 2000. ,
DOI : 10.1023/A:1001907321955
Whole genome genotyping technologies on the BeadArray??? platform, Biotechnology Journal, vol.314, issue.1, pp.41-49, 2007. ,
DOI : 10.1002/biot.200600213
Principal components analysis corrects for stratification in genome-wide association studies, Nature Genetics, vol.15, issue.8, pp.904-909, 2006. ,
DOI : 10.1038/ng1653
Inference of population structure using multilocus genotype data, Genetics, vol.155, pp.945-959, 2000. ,
WGAViewer: Software for genomic annotation of whole genome association studies, Genome Research, vol.18, issue.4, pp.640-643, 2008. ,
DOI : 10.1101/gr.071571.107