Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle.

Matjaž Simončič 1 Tadeja Režen 2 Peter Juvan 2 Damjana Rozman 2 Gregor Fazarinc 3 Catherine Fievet 4, 5 Bart Staels 4, 5 Simon Horvat 1, 6, *
* Auteur correspondant
1 University of Ljubljana
2 University of Ljubljana
3 Institute of Anatomy
4 EGID - Récepteurs nucléaires, maladies cardiovasculaires et diabète
5 Université Lille Nord de France
6 National Institute of Chemistry
Abstract : We identified novel candidate molecular targets and metabolic changes which can at least in part explain resistance to obesity development in the Lean line. The major difference between the Lean and Fat mice was in increased liver cholesterol biosynthesis gene mRNA expression, bile acid metabolism and changes in selected muscle genes' expression in the Lean line. The liver Abcb11 and muscle Dio2 were identified as novel positional candidate genes to explain part of the phenotypic difference between the Lean and Fat lines.
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Article dans une revue
BMC Genomics, BioMed Central, 2011, 12 (1), pp.96. 〈10.1186/1471-2164-12-96〉
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Soumis le : vendredi 18 mars 2011 - 12:26:53
Dernière modification le : lundi 8 octobre 2018 - 17:44:07
Document(s) archivé(s) le : jeudi 8 novembre 2012 - 12:10:29

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Matjaž Simončič, Tadeja Režen, Peter Juvan, Damjana Rozman, Gregor Fazarinc, et al.. Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle.. BMC Genomics, BioMed Central, 2011, 12 (1), pp.96. 〈10.1186/1471-2164-12-96〉. 〈inserm-00578091〉

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