Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2011

Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.

Résumé

The aspartic protease cathepsin-D (cath-D) is overexpressed by human epithelial breast cancer cells and is closely correlated with poor prognosis in breast cancer. The adipocyte is one of the most prominent cell types in the tumor-microenvironment of breast cancer, and clinical studies have shown that obesity increases the incidence of breast cancer. Here, we provide the first evidence that cath-D expression is up-regulated in adipose tissue from obese human beings, as well as in adipocytes from the obese C57BI6/J mouse. Cath-D expression is also increased during human and mouse adipocyte differentiation. We show that cath-D silencing in 3T3-F442A murine preadipocytes leads to lipid-depleted cells after adipogenesis induction, and inhibits of the expression of PPARγ, HSL and aP2 adipocyte differentiation markers. Altogether, our findings demonstrate the key role of cath-D in the control of adipogenesis, and suggest that cath-D may be a novel target in obesity.
Fichier principal
Vignette du fichier
paper14plosone.pdf (214.45 Ko) Télécharger le fichier
fig12papercath-D-1.tif (91.94 Ko) Télécharger le fichier
fig12papercath-D-2.tif (771.78 Ko) Télécharger le fichier
fig12papercath-D-3.tif (376.06 Ko) Télécharger le fichier
fig12papercath-D-4.tif (814.63 Ko) Télécharger le fichier
fig12papercath-D-5.tif (1.81 Mo) Télécharger le fichier
fig12papercath-D-6.tif (1.45 Mo) Télécharger le fichier
fig12papercath-D-Sup1.tif (803.84 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Format : Autre
Format : Autre
Format : Autre
Format : Autre
Format : Autre
Format : Autre
Format : Autre
Loading...

Dates et versions

inserm-00576566 , version 1 (14-03-2011)

Identifiants

Citer

Olivier Masson, Christine Prébois, Danielle Derocq, Aline Meulle, Cédric Dray, et al.. Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.: Cathepsin D, adipogenesis and obesity. PLoS ONE, 2011, 6 (2), pp.e16452. ⟨10.1371/journal.pone.0016452⟩. ⟨inserm-00576566⟩
202 Consultations
181 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More