Regulation of lipogenic genes in obesity

Abstract : Lipogenesis describes the process of fatty acid and triglyceride synthesis. Lipogenesis mainly occurs in liver and fat tissue and is under the coordinated control of hormonal, nutritional and transcription factors. Several transcription factors have been identified as critical regulators that mediate the effect of hormones and nutrients on gene transcription. This includes the Sterol Regulatory Element Binding Protein-1c “SREBP-1c”, the CCAAT/Enhancer-Binding Protein-alpha “C/EBPalpha”, the nuclear hormone receptors Liver X Receptors “LXRs”, the Peroxisome Proliferator-Activated Receptor gamma “PPARgamma”, the Estrogen Related Receptor alpha “ERRalpha”. The role of these transcription factors in these processes is reviewed and discussed. Although lipogenesis may appear as an attractive target for pharmacological treatment of obesity, recent insights into the metabolic consequences of non-adipose triglyceride storage has shifted attention to alternative targets.
Type de document :
Chapitre d'ouvrage
Regina Brigelius-Flohé and Hans-Georg Joost. Nutritional Genomics : Impact on Health and Disease, Wiley-VCH, pp.208-219, 2006
Liste complète des métadonnées

Littérature citée [54 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00576547
Contributeur : Stéphane Mandard <>
Soumis le : lundi 14 mars 2011 - 16:20:31
Dernière modification le : mardi 15 mars 2011 - 10:56:41
Document(s) archivé(s) le : mercredi 15 juin 2011 - 03:04:29

Fichiers

Mandard_and_Kersten_2006_HAL_I...
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : inserm-00576547, version 1

Collections

Citation

Stéphane Mandard, Sander Kersten. Regulation of lipogenic genes in obesity. Regina Brigelius-Flohé and Hans-Georg Joost. Nutritional Genomics : Impact on Health and Disease, Wiley-VCH, pp.208-219, 2006. 〈inserm-00576547〉

Partager

Métriques

Consultations de la notice

167

Téléchargements de fichiers

1777