NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis. - Archive ouverte HAL Access content directly
Journal Articles Carcinogenesis / CARCINOGENESIS(LONDON); Carcinogenesis (Oxford) Year : 2010

NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis.

(1) , (1) , (2, 3) , (2, 3) , (4) , (2) , (2) , (2) , (2) , (1)
1
2
3
4

Abstract

Gliomas are the most common primary brain tumor affecting human adults and remain a therapeutic challenge because cells of origin are still unknown. Here, we investigated the cellular origin of low-grade gliomas in a rat model based on transplacental exposure to N-ethyl-N-nitrosourea (ENU). Longitudinal magnetic resonance imaging coupled to immunohistological and immunocytochemical analyses were used to further characterize low-grade rat gliomas at different stages of evolution. We showed that early low-grade gliomas have characteristics of oligodendroglioma-like tumors and exclusively contain NG2-expressing slow dividing precursor cells, which express early markers of oligodendroglial lineage. These tumor-derived precursors failed to fully differentiate into oligodendrocytes and exhibited multipotential abilities in vitro. Moreover, a few glioma NG2+ cells are resistant to radiotherapy and may be responsible for tumor recurrence, frequently observed in humans. Overall, these findings suggest that transformed multipotent NG2 glial precursor cell may be a potential cell of origin in the genesis of rat ENU-induced oligodendroglioma-like tumors. This work may open up new perspectives for understanding biology of human gliomas.
Fichier principal
Vignette du fichier
Briancon_Marjollet_Carcinogenesis_2010.pdf (4.45 Mo) Télécharger le fichier
Vignette du fichier
inserm-00567905_edited.pdf (947.44 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00567905 , version 1 (22-07-2011)

Identifiers

Cite

Anne Briançon-Marjollet, Laurent Balenci, Manuel Fernandez, François Estève, Jérôme Honnorat, et al.. NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis.: Brain precursor cells and gliomas. Carcinogenesis / CARCINOGENESIS(LONDON); Carcinogenesis (Oxford), 2010, 31 (10), pp.1718-25. ⟨10.1093/carcin/bgq154⟩. ⟨inserm-00567905⟩
214 View
566 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More