Childbearing after hyperthermic intraperitoneal chemotherapy: results from an international survey.: Childbearing after HIPEC

Pablo Ortega-Deballon 1, 2, * Olivier Glehen 3 Edward Levine 4 Pompiliu Piso 5 Paul Sugarbaker 6 Andrea Hayes-Jordan 7 Audrey Facy 2 Naoual Bakrin 3 Patrick Rat 1, 2
* Auteur correspondant
1 LNC - Lipides - Nutrition - Cancer (U866)
2 Département de chirurgie thoracique et digestive [CHU de Dijon]
3 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
4 Baptist Medical Center
5 University Medical Center of Regensburg
6 Washington Cancer Institute
7 MD Anderson Cancer Center
Abstract : BACKGROUND: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) can improve survival in selected patients with primary or secondary peritoneal malignancies. With the opportunity for long-term survival, questions about the impact of those procedures in fertility in women of childbearing age can be raised. MATERIALS AND METHODS: An international survey was performed among all teams participating in the International Peritoneal Surface Malignancy Group in order to collect data about pregnancies and their outcome in women having undergone previous CRS with adjuvant HIPEC. RESULTS: There were 7 pregnancies reported after CRS and HIPEC in women treated for peritoneal malignancies. All these women conceived spontaneously, most of them within 2 years after the procedure. They delivered most often by vaginal way after an uneventful pregnancy. Their newborns were healthy, except 1 case of congenital diaphragmatic hernia requiring emergent surgery. There were 2 additional uneventful pregnancies reported after the diagnosis of pseudomyxoma peritonei and before CRS and HIPEC, with the support of the medical team. Another woman having undergone oocytes retrieval and embryo cryopreservation prior to the surgery was mother of twins after the procedure via a surrogate mother. CONCLUSION: Childbearing after cytoreductive surgery and heated intraperitoneal chemotherapy is possible in women conserving their genital organs after the procedure. The question of fertility should be considered and discussed in women in reproductive age prior to cytoreductive surgery and heated intraperitoneal chemotherapy. Different options could be offered in this setting. Multidisciplinary decision making involving surgical oncologists and fertility specialists is important.
Keywords : pregnancy childbearing peritoneal carcinomatosis pseudomyxoma HIPEC intraperitoneal chemotherapy mesothelioma
Type de document :
Article dans une revue
Annals of Surgical Oncology, Springer Verlag, 2011, 18 (8), pp.2297-301. 〈10.1245/s10434-011-1595-5〉
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Contributeur : Pablo Ortega Deballon <>
Soumis le : lundi 21 février 2011 - 11:04:35
Dernière modification le : vendredi 8 juin 2018 - 14:50:12
Document(s) archivé(s) le : dimanche 22 mai 2011 - 02:48:59

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Pablo Ortega-Deballon, Olivier Glehen, Edward Levine, Pompiliu Piso, Paul Sugarbaker, et al.. Childbearing after hyperthermic intraperitoneal chemotherapy: results from an international survey.: Childbearing after HIPEC. Annals of Surgical Oncology, Springer Verlag, 2011, 18 (8), pp.2297-301. 〈10.1245/s10434-011-1595-5〉. 〈inserm-00567418〉

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